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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Fibroblasts


Psychiatry related information on Fibroblasts


High impact information on Fibroblasts


Chemical compound and disease context of Fibroblasts


Biological context of Fibroblasts


Anatomical context of Fibroblasts


Associations of Fibroblasts with chemical compounds

  • Treatment of fibroblasts with neuraminidase exposes galactose residues, thus increasing the sensitivity to ricin eight fold [30].
  • Prior incubation of fibroblast monolayers with cholesterol, 25-hydroxycholesterol, or LDL progressively reduced the ability of the cells to bind 125I-labeled LDL at the high affinity site [31].
  • The crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 (FGFR1K) has been determined in its unliganded form to 2.0 angstroms resolution and in complex with with an ATP analog to 2.3 angstrosms A resolution [32].
  • Dexamethasone treatment results in a tenfold increase in the rate of fibronectin biosynthesis in HT1080 cells and a twofold increase in untransformed, normal human fibroblasts [33].
  • SV40-transformed mouse fibroblasts migrate upon, and spontaneously glycosylate, plastic substrates derivatized with chondroitin-6 sulfate and hyaluronic acid [34].

Gene context of Fibroblasts


Analytical, diagnostic and therapeutic context of Fibroblasts


  1. The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour. Lee, S.B., Kolquist, K.A., Nichols, K., Englert, C., Maheswaran, S., Ladanyi, M., Gerald, W.L., Haber, D.A. Nat. Genet. (1997) [Pubmed]
  2. Monoclonal antibodies NORM-1 and NORM-2 induce more normal behavior of tumor cells in vitro and reduce tumor growth in vivo. Vollmers, H.P., Imhof, B.A., Wieland, I., Hiesel, A., Birchmeier, W. Cell (1985) [Pubmed]
  3. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Boire, A., Covic, L., Agarwal, A., Jacques, S., Sherifi, S., Kuliopulos, A. Cell (2005) [Pubmed]
  4. Local mutagenesis of Rous sarcoma virus: the major sites of tyrosine and serine phosphorylation of pp60src are dispensable for transformation. Cross, F.R., Hanafusa, H. Cell (1983) [Pubmed]
  5. Receptor-mediated internalization of Pseudomonas toxin by mouse fibroblasts. FitzGerald, D., Morris, R.E., Saelinger, C.B. Cell (1980) [Pubmed]
  6. Altered glucose metabolism in fibroblasts from patients with Alzheimer's disease. Sims, N.R., Finegan, J.M., Blass, J.P. N. Engl. J. Med. (1985) [Pubmed]
  7. Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts. Helfgott, D.C., May, L.T., Sthoeger, Z., Tamm, I., Sehgal, P.B. J. Exp. Med. (1987) [Pubmed]
  8. Huntington disease and Tourette syndrome. II. Uptake of glutamic acid and other amino acids by fibroblasts. Comings, D.E., Goetz, I.E., Holden, J., Holtz, J. Am. J. Hum. Genet. (1981) [Pubmed]
  9. DNA damage induced by polyglutamine-expanded proteins. Giuliano, P., De Cristofaro, T., Affaitati, A., Pizzulo, G.M., Feliciello, A., Criscuolo, C., De Michele, G., Filla, A., Avvedimento, E.V., Varrone, S. Hum. Mol. Genet. (2003) [Pubmed]
  10. E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Loveys, D.A., Streiff, M.B., Kato, G.J. Nucleic Acids Res. (1996) [Pubmed]
  11. The heparin-binding (fibroblast) growth factor family of proteins. Burgess, W.H., Maciag, T. Annu. Rev. Biochem. (1989) [Pubmed]
  12. Phospholipase D: enzymology, mechanisms of regulation, and function. Exton, J.H. Physiol. Rev. (1997) [Pubmed]
  13. Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. Bradshaw, P.S., Stavropoulos, D.J., Meyn, M.S. Nat. Genet. (2005) [Pubmed]
  14. Chfr is required for tumor suppression and Aurora A regulation. Yu, X., Minter-Dykhouse, K., Malureanu, L., Zhao, W.M., Zhang, D., Merkle, C.J., Ward, I.M., Saya, H., Fang, G., van Deursen, J., Chen, J. Nat. Genet. (2005) [Pubmed]
  15. Polycomb group protein ezh2 controls actin polymerization and cell signaling. Su, I.H., Dobenecker, M.W., Dickinson, E., Oser, M., Basavaraj, A., Marqueron, R., Viale, A., Reinberg, D., Wülfing, C., Tarakhovsky, A. Cell (2005) [Pubmed]
  16. Dexamethasone-resistant cystic fibrosis fibroblasts show cross-resistance to sex steroids. Breslow, J.L., Epstein, J., Fontaine, J.H. Cell (1978) [Pubmed]
  17. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E., Yuan, J. Cell (1998) [Pubmed]
  18. Low activities of the pyruvate and oxoglutarate dehydrogenase complexes in five patients with Friedreich's ataxia. Blass, J.P., Kark, R.A., Menon, N.K. N. Engl. J. Med. (1976) [Pubmed]
  19. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. Boers, G.H., Smals, A.G., Trijbels, F.J., Fowler, B., Bakkeren, J.A., Schoonderwaldt, H.C., Kleijer, W.J., Kloppenborg, P.W. N. Engl. J. Med. (1985) [Pubmed]
  20. Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Zhang, Q., Yoshimatsu, Y., Hildebrand, J., Frisch, S.M., Goodman, R.H. Cell (2003) [Pubmed]
  21. Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Morla, A.O., Draetta, G., Beach, D., Wang, J.Y. Cell (1989) [Pubmed]
  22. Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA. Kastan, M.B., Gowans, B.J., Lieberman, M.W. Cell (1982) [Pubmed]
  23. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Honda, H., Oda, H., Nakamoto, T., Honda, Z., Sakai, R., Suzuki, T., Saito, T., Nakamura, K., Nakao, K., Ishikawa, T., Katsuki, M., Yazaki, Y., Hirai, H. Nat. Genet. (1998) [Pubmed]
  24. Mouse development and cell proliferation in the absence of D-cyclins. Kozar, K., Ciemerych, M.A., Rebel, V.I., Shigematsu, H., Zagozdzon, A., Sicinska, E., Geng, Y., Yu, Q., Bhattacharya, S., Bronson, R.T., Akashi, K., Sicinski, P. Cell (2004) [Pubmed]
  25. Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts. Lassar, A.B., Paterson, B.M., Weintraub, H. Cell (1986) [Pubmed]
  26. Shmoos, rafts, and uropods- the many facets of cell polarity. Dustin, M.L. Cell (2002) [Pubmed]
  27. Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Chen, M., Kasahara, N., Keene, D.R., Chan, L., Hoeffler, W.K., Finlay, D., Barcova, M., Cannon, P.M., Mazurek, C., Woodley, D.T. Nat. Genet. (2002) [Pubmed]
  28. A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Shimokado, K., Raines, E.W., Madtes, D.K., Barrett, T.B., Benditt, E.P., Ross, R. Cell (1985) [Pubmed]
  29. The participation of alpha-actinin in the capping of cell membrane components. Geiger, B., Singer, S.J. Cell (1979) [Pubmed]
  30. Studies on the galactose-binding site of ricin and the hybrid toxin Man6P-ricin. Youle, R.J., Murray, G.J., Neville, D.M. Cell (1981) [Pubmed]
  31. Regulation of the activity of the low density lipoprotein receptor in human fibroblasts. Brown, M.S., Goldstein, J.L. Cell (1975) [Pubmed]
  32. Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Mohammadi, M., Schlessinger, J., Hubbard, S.R. Cell (1996) [Pubmed]
  33. Regulation of fibronectin biosynthesis by glucocorticoids in human fibrosarcoma cells and normal fibroblasts. Oliver, N., Newby, R.F., Furcht, L.T., Bourgeois, S. Cell (1983) [Pubmed]
  34. Spontaneous glycosylation of glycosaminoglycan substrates by adherent fibroblasts. Turley, E.A., Roth, S. Cell (1979) [Pubmed]
  35. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Dulić, V., Kaufmann, W.K., Wilson, S.J., Tlsty, T.D., Lees, E., Harper, J.W., Elledge, S.J., Reed, S.I. Cell (1994) [Pubmed]
  36. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., Jaenisch, R. Nat. Genet. (2001) [Pubmed]
  37. A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Muenke, M., Schell, U., Hehr, A., Robin, N.H., Losken, H.W., Schinzel, A., Pulleyn, L.J., Rutland, P., Reardon, W., Malcolm, S. Nat. Genet. (1994) [Pubmed]
  38. Telomerase maintains telomere structure in normal human cells. Masutomi, K., Yu, E.Y., Khurts, S., Ben-Porath, I., Currier, J.L., Metz, G.B., Brooks, M.W., Kaneko, S., Murakami, S., DeCaprio, J.A., Weinberg, R.A., Stewart, S.A., Hahn, W.C. Cell (2003) [Pubmed]
  39. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Jabs, E.W., Li, X., Scott, A.F., Meyers, G., Chen, W., Eccles, M., Mao, J.I., Charnas, L.R., Jackson, C.E., Jaye, M. Nat. Genet. (1994) [Pubmed]
  40. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Kandel, J., Bossy-Wetzel, E., Radvanyi, F., Klagsbrun, M., Folkman, J., Hanahan, D. Cell (1991) [Pubmed]
  41. Viral and cellular fos proteins: a comparative analysis. Curran, T., Miller, A.D., Zokas, L., Verma, I.M. Cell (1984) [Pubmed]
  42. Microinjection and localization of a 130K protein in living fibroblasts: a relationship to actin and fibronectin. Burridge, K., Feramisco, J.R. Cell (1980) [Pubmed]
  43. Initial adhesion of human fibroblasts in serum-free medium: possible role of secreted fibronectin. Grinnell, F., Feld, M.K. Cell (1979) [Pubmed]
  44. Fibronectin: a chromatin-associated protein? Zardi, L., Siri, A., Carnemolla, B., Santi, L., Gardner, W.D., Hoch, S.O. Cell (1979) [Pubmed]
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