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Chemical Compound Review

CHEMBL26128     phenoxyphosphonic acid

Synonyms: SureCN20263, AGN-PC-004LNF, ACMC-1BB8F, CHEBI:37548, ANW-35851, ...
 
 
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Disease relevance of phenoxyphosphonic acid

 

High impact information on phenoxyphosphonic acid

 

Gene context of phenoxyphosphonic acid

  • The recently reported high PTP1B inhibitory potency of similar phenylphosphate mimicking moieties displayed in small molecule, non-peptide structures, raises questions on the limitations of using peptides as platforms for pTyr mimetics in the discovery of small molecule inhibitors [6].
  • The parenchymal acid phosphatase isozymes hydrolyze preferentially AMP and CMP, while the sinusoidal isozyme hydrolyzes phenylphosphate [7].
  • Sulfotransferase production was strongly inhibited by phenylphosphate esters [8].
 

Analytical, diagnostic and therapeutic context of phenoxyphosphonic acid

References

  1. Evidence that phenol phosphorylation to phenylphosphate is the first step in anaerobic phenol metabolism in a denitrifying Pseudomonas sp. Lack, A., Fuchs, G. Arch. Microbiol. (1994) [Pubmed]
  2. Mechanism of activation for Zap-70 catalytic activity. LoGrasso, P.V., Hawkins, J., Frank, L.J., Wisniewski, D., Marcy, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase. David, M., Romero, G., Zhang, Z.Y., Dixon, J.E., Larner, A.C. J. Biol. Chem. (1993) [Pubmed]
  4. Phenylphosphate synthase: a new phosphotransferase catalyzing the first step in anaerobic phenol metabolism in Thauera aromatica. Schmeling, S., Narmandakh, A., Schmitt, O., Gad'on, N., Schühle, K., Fuchs, G. J. Bacteriol. (2004) [Pubmed]
  5. Genes involved in anaerobic metabolism of phenol in the bacterium Thauera aromatica. Breinig, S., Schiltz, E., Fuchs, G. J. Bacteriol. (2000) [Pubmed]
  6. Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains. Gao, Y., Wu, L., Luo, J.H., Guo, R., Yang, D., Zhang, Z.Y., Burke, T.R. Bioorg. Med. Chem. Lett. (2000) [Pubmed]
  7. Effect of endotoxin on rat liver. Analysis of acid phosphatase isozymes in the liver of normal and endotoxin-treated rats. Hirata, K., Kaneko, A., Ogawa, K., Hayasaka, H., Onoé, T. Lab. Invest. (1980) [Pubmed]
  8. Induction and inhibition of novel sulfotransferase in a human intestinal bacterium, Eubacterium sp. A-44. Kim, D.H., Kobashi, K. Chem. Pharm. Bull. (1991) [Pubmed]
  9. Highly sensitive assay for alkaline and acid phosphatase activities by high-performance liquid chromatography with electrochemical detection. Togari, A., Sakai, J., Matsumoto, S., Nagatsu, T. J. Chromatogr. (1987) [Pubmed]
 
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