Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L2SZH (5S,6S)-6-(4-hydroxyphenyl)- 6-methyl-5-[9...

Synonyms: LS-183775, ZM 189154, ZM 189,154

Rasmussen, T.H. et al., Dukes, M. et al.

Rasmussen, Teh, Bjerregaard, Korsgaard,

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High impact information on ZM 189154

ZM 189,154 displays no intrinsic oestrogen-agonist activity on uterus, vagina, bone, LH secretion or growth rate in OVX rats [1].

Analytical, diagnostic and therapeutic context of ZM 189154

A group of fish were exposed to 4-tOP (50 microg l(-1)) concomitantly with the anti-estrogen ZM 189,154 (20 microg g(-1) week(-1), i.p.). The Vtg concentration in plasma was measured by enzyme-linked immunosorbent assay [2].

References

Effects of a non-steroidal pure antioestrogen, ZM 189,154, on oestrogen target organs of the rat including bones. Dukes, M., Chester, R., Yarwood, L., Wakeling, A.E. J. Endocrinol. (1994) [Pubmed]
Anti-estrogen prevents xenoestrogen-induced testicular pathology of eelpout (Zoarces viviparus). Rasmussen, T.H., Teh, S.J., Bjerregaard, P., Korsgaard, B. Aquat. Toxicol. (2005) [Pubmed]

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