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Disease relevance of Uterus


Psychiatry related information on Uterus

  • OBJECTIVE: Erythromycin is a stimulant of motor activity in the stomach, but its effects on the uterus have not been studied and only its antibiotic properties have been considered in the treatment of idiopathic preterm labor [6].
  • The concept of hysteria is traced from Hippocrates, where it was though to be caused by a wandering uterus, through Galen and up to Freud [7].
  • P treatment significantly increased superficial Ca2+-binding and decreased electrical (field stimulation) and pharmacological (oxytocine, prostaglandin F2 alfa) excitability of Pp uterus after a latency period of 8--12 h [8].
  • We conclude that estrogen impairs the defense mechanisms of the genital tract of non-castrated female rats, enhancing bacterial growth in the vagina and ascending infection to the uterus, tubes and ovaries [9].
  • During the critical period of receptor maturation within the first 5 days after birth female rats were treated with benzpyrene three times and their uterus estrogen receptor characteristic were examined in adulthood [10].

High impact information on Uterus

  • In the uterus, returning estrogen action concomitantly upregulates endometrial oxytocin receptors [11].
  • Thus the uterus can be regarded as a transducer that converts intermittent neural signals from the hypothalamus, in the form of episodic oxytocin secretion, into luteolytic pulses of uterine PGF2alpha [11].
  • In mammalian uterus and other smooth muscle target cells, there is no evidence for direct involvement of cyclic AMP in the contractile response to oxytocin and other neurohypophysial peptides [12].
  • Mutations in AMH or AMHR2 in humans and mice disrupt signaling, producing male pseudohermaphrodites that possess oviducts and uteri [13].
  • Female Nhlh2-/- mice reared alone are hypogonadal, but when reared in the presence of males, their ovaries and uteri develop normally and they are fertile [14].

Chemical compound and disease context of Uterus


Biological context of Uterus


Anatomical context of Uterus

  • Loss of progesterone action may permit the return of estrogen action, both centrally in the hypothalamus and peripherally in the uterus [11].
  • XY Tfm/MIS double mutants developed as females, with a uterus, coiled oviducts, and no male reproductive organs except undescended dysfunctional testes [24].
  • IRAG was found in many tissues including aorta, trachea and uterus, and was localized perinuclearly after heterologous expression in COS-7 cells [25].
  • The production of MIS in the male fetus brings about the regression of the Müllerian ducts, the anlagen of the uterus, oviducts, and upper vagina [26].
  • There are reports that estrogen is made by the rabbit blastocyst (61), and estrogens have been used to induce implantation in mice (62), but whether estrogens act through ERs in the embryo or in the maternal uterus is not known [27].

Associations of Uterus with chemical compounds


Gene context of Uterus

  • Oestrogenic actions of AhR agonists were detected in wild-type ovariectomized mouse uteri, but were absent in AhR-/- or ER-alpha-/- ovariectomized mice [32].
  • We have recently demonstrated that HOXA10 is expressed in the adult human uterus [33].
  • P-cadherin is a subclass of Ca2+-dependent cell-cell adhesion molecules present in mouse placenta, where its localization suggests a function of connecting the embryo to the uterus (Nose, A., and M. Takeichi. 1986. J. Cell Biol. 103:2649-2658) [34].
  • Many of the effects of estrogens on the uterus are mediated by ERalpha, the predominant ER in the mature organ [35].
  • The estrogen receptor alpha knockout (ERKO) mouse uterus was observed to express PR mRNA that cannot be induced by estrogen [36].

Analytical, diagnostic and therapeutic context of Uterus


  1. Estrogen receptor assay in the differential diagnosis of adenocarcinomas. Kiang, D.T., Kennedy, B.J. JAMA (1977) [Pubmed]
  2. Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma. Horiuchi, A., Nikaido, T., Taniguchi, S., Fujii, S. J. Natl. Cancer Inst. (1999) [Pubmed]
  3. Spontaneous occurrence of atypical hyperplasia and adenocarcinoma of the uterus in androgen-sterilized SD rats. Morikawa, S., Sekiya, S., Naitoh, M., Iwasawa, H., Takeda, B., Takamizawa, H. J. Natl. Cancer Inst. (1982) [Pubmed]
  4. Effect of prolactin and estradiol on cell proliferation in the uterus and the MXT mouse mammary neoplasm. Kiss, R., de Launoit, Y., L'Hermite-Balériaux, M., L'Hermite, M., Paridaens, R.J., Danguy, A.J., Pasteels, J.L. J. Natl. Cancer Inst. (1987) [Pubmed]
  5. Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage. Maccarrone, M., Valensise, H., Bari, M., Lazzarin, N., Romanini, C., Finazzi-Agrò, A. Lancet (2000) [Pubmed]
  6. Effects of erythromycin on contractility of isolated myometrium from pregnant rats. Granovsky-Grisaru, S., Ilan, D., Grisaru, D., Lavie, O., Aboulafia, I., Diamant, Y.Z., Hanani, M. Am. J. Obstet. Gynecol. (1998) [Pubmed]
  7. On constructing the disorder of hysteria. Allison, D.B., Roberts, M.S. The Journal of medicine and philosophy. (1994) [Pubmed]
  8. Cyclic nucleotides do not mediate excitability-suppressing cellular action of progesterone in the rabbit myometrium. Rubányi, G. Acta physiologica Academiae Scientiarum Hungaricae. (1980) [Pubmed]
  9. Spontaneous inflammatory pelvic disease in adult non-castrated female rats treated with estrogen. Ramos, A.M., Perazzio, S., Camargos, A.F., Pereira, F.E. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. (2005) [Pubmed]
  10. Uterus estrogen receptors' binding capacity is reduced in rat if exposed by benzpyrene neonatally. Csaba, G., Inczefi-Gonda, A. J. Dev. Physiol. (1993) [Pubmed]
  11. Luteolysis: a neuroendocrine-mediated event. McCracken, J.A., Custer, E.E., Lamsa, J.C. Physiol. Rev. (1999) [Pubmed]
  12. Stimulus-response coupling in neurohypophysial peptide target cells. Jard, S., Bockaert, J. Physiol. Rev. (1975) [Pubmed]
  13. Requirement of Bmpr1a for Müllerian duct regression during male sexual development. Jamin, S.P., Arango, N.A., Mishina, Y., Hanks, M.C., Behringer, R.R. Nat. Genet. (2002) [Pubmed]
  14. Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Good, D.J., Porter, F.D., Mahon, K.A., Parlow, A.F., Westphal, H., Kirsch, I.R. Nat. Genet. (1997) [Pubmed]
  15. Antibodies to rabbit progesterone receptor: crossreaction with human receptor. Logeat, F., Hai, M.T., Milgrom, E. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  16. Cannabinoid ligand-receptor signaling in the mouse uterus. Das, S.K., Paria, B.C., Chakraborty, I., Dey, S.K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  17. Increased risk of malignant mullerian tumor of the uterus among women with breast cancer treated by tamoxifen. Bouchardy, C., Verkooijen, H.M., Fioretta, G., Sappino, A.P., Vlastos, G. J. Clin. Oncol. (2002) [Pubmed]
  18. Biochemical and immunological properties of the human carcinoma-associated CAR-3 epitope defined by the monoclonal antibody AR-3. Prat, M., Medico, E., Rossino, P., Garrino, C., Comoglio, P.M. Cancer Res. (1989) [Pubmed]
  19. Uterine luteolytic hormone: a physiological role for prostaglandin F2alpha. Horton, E.W., Poyser, N.L. Physiol. Rev. (1976) [Pubmed]
  20. High-affinity anti-oestrogen binding site distinct from the oestrogen receptor. Sutherland, R.L., Murphy, L.C., San Foo, M., Green, M.D., Whybourne, A.M., Krozowski, Z.S. Nature (1980) [Pubmed]
  21. Oxytocin gene expression in rat uterus. Lefebvre, D.L., Giaid, A., Bennett, H., Larivière, R., Zingg, H.H. Science (1992) [Pubmed]
  22. Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation. Mishina, Y., Rey, R., Finegold, M.J., Matzuk, M.M., Josso, N., Cate, R.L., Behringer, R.R. Genes Dev. (1996) [Pubmed]
  23. First unaffected pregnancy using preimplantation genetic diagnosis for sickle cell anemia. Xu, K., Shi, Z.M., Veeck, L.L., Hughes, M.R., Rosenwaks, Z. JAMA (1999) [Pubmed]
  24. Müllerian-inhibiting substance function during mammalian sexual development. Behringer, R.R., Finegold, M.J., Cate, R.L. Cell (1994) [Pubmed]
  25. Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Schlossmann, J., Ammendola, A., Ashman, K., Zong, X., Huber, A., Neubauer, G., Wang, G.X., Allescher, H.D., Korth, M., Wilm, M., Hofmann, F., Ruth, P. Nature (2000) [Pubmed]
  26. Abnormal sexual development in transgenic mice chronically expressing müllerian inhibiting substance. Behringer, R.R., Cate, R.L., Froelick, G.J., Palmiter, R.D., Brinster, R.L. Nature (1990) [Pubmed]
  27. Estrogen receptors, estradiol, and diethylstilbestrol in early development: the mouse as a model for the study of estrogen receptors and estrogen sensitivity in embryonic development of male and female reproductive tracts. Greco, T.L., Duello, T.M., Gorski, J. Endocr. Rev. (1993) [Pubmed]
  28. Secretion of a progesterone-induced inhibitor of plasminogen activator by the porcine uterus. Mullins, D.E., Bazer, F.W., Roberts, R.M. Cell (1980) [Pubmed]
  29. The interaction of estradiol-receptor protein with the genome: an argument for the existence of undetected specific sites. Yamamoto, K., Alberts, B. Cell (1975) [Pubmed]
  30. alpha Adrenoreceptors but not beta adrenoreceptors increase in rabbit uterus with oestrogen. Roberts, J.M., Insel, P.A., Goldfien, R.D., Goldfien, A. Nature (1977) [Pubmed]
  31. Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation. Seppälä, M., Taylor, R.N., Koistinen, H., Koistinen, R., Milgrom, E. Endocr. Rev. (2002) [Pubmed]
  32. Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Ohtake, F., Takeyama, K., Matsumoto, T., Kitagawa, H., Yamamoto, Y., Nohara, K., Tohyama, C., Krust, A., Mimura, J., Chambon, P., Yanagisawa, J., Fujii-Kuriyama, Y., Kato, S. Nature (2003) [Pubmed]
  33. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. Taylor, H.S., Arici, A., Olive, D., Igarashi, P. J. Clin. Invest. (1998) [Pubmed]
  34. Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues. Shimoyama, Y., Yoshida, T., Terada, M., Shimosato, Y., Abe, O., Hirohashi, S. J. Cell Biol. (1989) [Pubmed]
  35. Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus. Weihua, Z., Saji, S., Mäkinen, S., Cheng, G., Jensen, E.V., Warner, M., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  36. Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor alpha knockout mouse uterus. Curtis, S.W., Clark, J., Myers, P., Korach, K.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  37. The involvement of interleukin (IL)-15 in regulating the differentiation of granulated metrial gland cells in mouse pregnant uterus. Ye, W., Zheng, L.M., Young, J.D., Liu, C.C. J. Exp. Med. (1996) [Pubmed]
  38. Effect of castration and 17 beta-estradiol pulse on cell proliferation in the uterus and the MXT mouse mammary tumor. Paridaens, R.J., Danguy, A.J., Leclercq, G., Kiss, R., Heuson, J.C. J. Natl. Cancer Inst. (1985) [Pubmed]
  39. Ultrastructural localization of the progesterone receptor by an immunogold method: effect of hormone administration. Perrot-Applanat, M., Groyer-Picard, M.T., Logeat, F., Milgrom, E. J. Cell Biol. (1986) [Pubmed]
  40. Occurrence and immunolocalization of plectin in tissues. Wiche, G., Krepler, R., Artlieb, U., Pytela, R., Denk, H. J. Cell Biol. (1983) [Pubmed]
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