Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

DHBG 2-amino-9-(3,4- dihydroxybutyl)-3H-purin-6- one

Synonyms: SureCN571079, AG-H-33194, AC1Q6IAO, CTK5F0721, CTK8D5099, ...

Ericson, A.C. et al., Larsson, A. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BRN 5073058

9-(3,4-Dihydroxybutyl)guanine was selectively phosphorylated by herpes simplex virus thymidine kinase and had a high affinity for this enzyme, with an inhibition constant of 1.5 microM [1].

High impact information on BRN 5073058

Three acyclic guanosine analogs with similar structures, the (R) and (S) forms of 9-(3,4-dihydroxybutyl)guanine and 9-(4-hydroxybutyl)guanine, were compared for antiherpes activity in vivo and in vitro [2].

References

9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication. Larsson, A., Oberg, B., Alenius, S., Hagberg, C.E., Johansson, N.G., Lindborg, B., Stening, G. Antimicrob. Agents Chemother. (1983) [Pubmed]
Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine. Ericson, A.C., Larsson, A., Aoki, F.Y., Yisak, W.A., Johansson, N.G., Oberg, B., Datema, R. Antimicrob. Agents Chemother. (1985) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share