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MeSH Review

Herpes Simplex

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Disease relevance of Herpes Simplex



Psychiatry related information on Herpes Simplex


High impact information on Herpes Simplex


Chemical compound and disease context of Herpes Simplex


Biological context of Herpes Simplex


Anatomical context of Herpes Simplex


Gene context of Herpes Simplex


Analytical, diagnostic and therapeutic context of Herpes Simplex



  1. Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters. Post, L.E., Mackem, S., Roizman, B. Cell (1981) [Pubmed]
  2. Vidarabine versus acyclovir therapy in herpes simplex encephalitis. Whitley, R.J., Alford, C.A., Hirsch, M.S., Schooley, R.T., Luby, J.P., Aoki, F.Y., Hanley, D., Nahmias, A.J., Soong, S.J. N. Engl. J. Med. (1986) [Pubmed]
  3. Herpesvirus infections of pregnancy. Part II: Herpes simplex virus and varicella-zoster virus infections. Stagno, S., Whitley, R.J. N. Engl. J. Med. (1985) [Pubmed]
  4. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Mannick, J.B., Asano, K., Izumi, K., Kieff, E., Stamler, J.S. Cell (1994) [Pubmed]
  5. Introduction of the herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNA. Minson, A.C., Wildy, P., Buchan, A., Darby, G. Cell (1978) [Pubmed]
  6. Herpes simplex virus type 1 blocks the apoptotic host cell defense mechanisms that target Bcl-2 and manipulates activation of p38 mitogen-activated protein kinase to improve viral replication. Zachos, G., Koffa, M., Preston, C.M., Clements, J.B., Conner, J. J. Virol. (2001) [Pubmed]
  7. Aciclovir protects against quinolinic-acid-induced oxidative neurotoxicity. Müller, A.C., Maharaj, H., Maharaj, D.S., Daya, S. J. Pharm. Pharmacol. (2005) [Pubmed]
  8. The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder. Dickerson, F.B., Boronow, J.J., Stallings, C., Origoni, A.E., Cole, S., Leister, F., Krivogorsky, B., Yolken, R.H. Bipolar disorders. (2006) [Pubmed]
  9. Transient Kluver-Bucy syndrome following complex partial status epilepticus. Varon, D., Pritchard, P.B., Wagner, M.T., Topping, K. Epilepsy & behavior : E&B. (2003) [Pubmed]
  10. Commentary on 'Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of Alzheimer's disease' by Prasanna Satpute-Krishnan et al. Aging Cell Vol. 2, Issue 6, 305-318 (2003). Itzhaki, R.F., Dobson, C.B., Wozniak, M.A. Aging Cell (2004) [Pubmed]
  11. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Shukla, D., Liu, J., Blaiklock, P., Shworak, N.W., Bai, X., Esko, J.D., Cohen, G.H., Eisenberg, R.J., Rosenberg, R.D., Spear, P.G. Cell (1999) [Pubmed]
  12. Acyclovir for recurrent herpes simplex virus ocular disease. Jabs, D.A. N. Engl. J. Med. (1998) [Pubmed]
  13. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Bush, T.G., Savidge, T.C., Freeman, T.C., Cox, H.J., Campbell, E.A., Mucke, L., Johnson, M.H., Sofroniew, M.V. Cell (1998) [Pubmed]
  14. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Montgomery, R.I., Warner, M.S., Lum, B.J., Spear, P.G. Cell (1996) [Pubmed]
  15. The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. Wilson, A.C., LaMarco, K., Peterson, M.G., Herr, W. Cell (1993) [Pubmed]
  16. Ineffectiveness of topical adenine arabinoside 5'-monophosphate in the treatment of recurrent herpes simplex labialis. Spruance, S.L., Crumpacker, C.S., Haines, H., Bader, C., Mehr, K., MacCalman, J., Schnipper, L.E., Klauber, M.R., Overall, J.C. N. Engl. J. Med. (1979) [Pubmed]
  17. A controlled trial comparing foscarnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. Safrin, S., Crumpacker, C., Chatis, P., Davis, R., Hafner, R., Rush, J., Kessler, H.A., Landry, B., Mills, J. N. Engl. J. Med. (1991) [Pubmed]
  18. Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA. Karin, M., Haslinger, A., Holtgreve, H., Cathala, G., Slater, E., Baxter, J.D. Cell (1984) [Pubmed]
  19. Inhibition of VSV binding and infectivity by phosphatidylserine: is phosphatidylserine a VSV-binding site? Schlegel, R., Tralka, T.S., Willingham, M.C., Pastan, I. Cell (1983) [Pubmed]
  20. An immunologically active chimaeric protein containing herpes simplex virus type 1 glycoprotein D. Weis, J.H., Enquist, L.W., Salstrom, J.S., Watson, R.J. Nature (1983) [Pubmed]
  21. Cloned mouse mammary tumor virus DNA is biologically active in transfected mouse cells and its expression is stimulated by glucocorticoid hormones. Buetti, E., Diggelmann, H. Cell (1981) [Pubmed]
  22. A generalized technique for deletion of specific genes in large genomes: alpha gene 22 of herpes simplex virus 1 is not essential for growth. Post, L.E., Roizman, B. Cell (1981) [Pubmed]
  23. 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. Südhof, T.C., Russell, D.W., Brown, M.S., Goldstein, J.L. Cell (1987) [Pubmed]
  24. 6-Hydroxydopamine potentiates acute herpes simplex virus infection of the superior cervical ganglion in mice. Price, R.W. Science (1979) [Pubmed]
  25. A genetic approach to promoter recognition during trans induction of viral gene expression. Coen, D.M., Weinheimer, S.P., McKnight, S.L. Science (1986) [Pubmed]
  26. Acyclovir prophylaxis of herpes-simplex-virus infections. Saral, R., Burns, W.H., Laskin, O.L., Santos, G.W., Lietman, P.S. N. Engl. J. Med. (1981) [Pubmed]
  27. Expression of H-2, laminin and SV40 T and TASA on differentiation of transformed murine teratocarcinoma cells. Knowles, B.B., Pan, S., Solter, D., Linnenbach, A., Croce, C., Huebner, K. Nature (1980) [Pubmed]
  28. Transcription of DNA injected into Xenopus oocytes is influenced by template topology. Harland, R.M., Weintraub, H., McKnight, S.L. Nature (1983) [Pubmed]
  29. Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus. Tenser, R.B., Miller, R.L., Rapp, F. Science (1979) [Pubmed]
  30. GAL4-VP16 is an unusually potent transcriptional activator. Sadowski, I., Ma, J., Triezenberg, S., Ptashne, M. Nature (1988) [Pubmed]
  31. A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes. Gendelman, H.E., Friedman, R.M., Joe, S., Baca, L.M., Turpin, J.A., Dveksler, G., Meltzer, M.S., Dieffenbach, C. J. Exp. Med. (1990) [Pubmed]
  32. Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. Tang, Q., Hendricks, R.L. J. Exp. Med. (1996) [Pubmed]
  33. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. Lund, J., Sato, A., Akira, S., Medzhitov, R., Iwasaki, A. J. Exp. Med. (2003) [Pubmed]
  34. A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. Mittler, G., Stühler, T., Santolin, L., Uhlmann, T., Kremmer, E., Lottspeich, F., Berti, L., Meisterernst, M. EMBO J. (2003) [Pubmed]
  35. High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Capecchi, M.R. Cell (1980) [Pubmed]
  36. Inflammatory thoughts about glioma gene therapy. Kielian, T., Hickey, W.F. Nat. Med. (1999) [Pubmed]
  37. Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug. Saito, Y., Price, R.W., Rottenberg, D.A., Fox, J.J., Su, T.L., Watanabe, K.A., Philips, F.S. Science (1982) [Pubmed]
  38. Prevention of herpesvirus infections in renal allograft recipients by low-dose oral acyclovir. Seale, L., Jones, C.J., Kathpalia, S., Jackson, G.G., Mozes, M., Maddux, M.S., Packham, D. JAMA (1985) [Pubmed]
  39. Obstacle to early diagnosis of herpes simplex encephalitis via CSF. Thomas, E.E., Norman, M.G., Berry, K. Lancet (1990) [Pubmed]
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