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Chemical Compound Review:

DEIB N-(2-diethylaminoethyl)-4- iodo-benzamide

Synonyms: I-BZA, CHEMBL13564, ACMC-1C9XD, AG-D-21437, SureCN1209964, ...

Labarre, P. et al., Chehade, F. et al., Moins, N. et al., Michelot, J.M. et al., Moreau, M.F. et al.

Moins, Papon, Seguin, Gardette, Moreau, Labarre, Bayle, Michelot, Gramain, Madelmont, Veyre, Labarre, Papon, Moreau, Moins, Bayle, Veyre, Madelmont,

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Disease relevance of AIDS158258

N-(2-diethylaminoethyl)-4-iodobenzamide was selected for its highest melanoma uptake: 60 min after IV injection of 6.5% and 4% ID/g, respectively for murine B16 and human melanotic melanoma [1].
Their synthesis, radioiodination and biodistribution in B16 melanoma bearing C57BL6 mice are described and compared to [125I] labeled N-(2-diethylaminoethyl)-4-iodobenzamide ([125I]BZA), our reference compound [2].
N-(2-Diethylaminoethyl)-4-iodobenzamide (BZA) is a radiopharmaceutical recently developed in our laboratory for the scintigraphic detection of melanoma and metastases [3].

Chemical compound and disease context of AIDS158258

The cellular uptake and incorporation in macromolecules of iodine-125 labelled N-(2-diethylaminoethyl)-4-iodobenzamide ([125I]BZA), a melanoma imaging agent, was studied using human melanoma cells M3Dau (amelanotic) and M4Beu (melanotic) [4].

Analytical, diagnostic and therapeutic context of AIDS158258

Using secondary ion mass spectrometry (SIMS), we studied the microscopic distribution of N-(2 diethylaminoethyl)-4 iodobenzamide (I-BZA) in B16 murine melanoma inoculated to C57BL/6J1 Co mice as well as in normal pigmented skin [5].

References

Synthesis and evaluation of new iodine-125 radiopharmaceuticals as potential tracers for malignant melanoma. Michelot, J.M., Moreau, M.F., Labarre, P.G., Madelmont, J.C., Veyre, A.J., Papon, J.M., Parry, D.F., Bonafous, J.F., Boire, J.Y., Desplanches, G.G. J. Nucl. Med. (1991) [Pubmed]
Synthesis, characterization and comparative biodistribution study of a new series of p-iodine-125 benzamides as potential melanoma imaging agents. Moins, N., Papon, J., Seguin, H., Gardette, D., Moreau, M.F., Labarre, P., Bayle, M., Michelot, J., Gramain, J.C., Madelmont, J.C., Veyre, A. Nucl. Med. Biol. (2001) [Pubmed]
Synthesis, radiolabeling, and preliminary evaluation in mice of some (N-diethylaminoethyl)-4-iodobenzamide derivatives as melanoma imaging agents. Moreau, M.F., Michelot, J., Papon, J., Bayle, M., Labarre, P., Madelmont, J.C., Parry, D., Boire, J.Y., Moins, N., Seguin, H. Nucl. Med. Biol. (1995) [Pubmed]
Melanin affinity of N-(2-diethylaminoethyl)-4-iodobenzamide, an effective melanoma imaging agent. Labarre, P., Papon, J., Moreau, M.F., Moins, N., Bayle, M., Veyre, A., Madelmont, J.C. Melanoma Res. (2002) [Pubmed]
Distribution of I-BZA (N-2-diethylaminoethyl-4-iodobenzamide) in grafted melanoma and normal skin: a study by secondary ion mass spectroscopy. Chehade, F., De Labriolle-Vaylet, C., Michelot, J., Moins, N., Moreau, M.F., Hindié, E., Papon, J., Escaig, F., Galle, P., Veyre, A. Cell. Mol. Biol. (Noisy-le-grand) (2001) [Pubmed]

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