The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Iodine-125     iodane

Synonyms: AC1L2XIQ, 125-Iodine, Iodine, isotope of mass 125, Iodine, isotope of mass 125, at.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of iodane


Psychiatry related information on iodane


High impact information on iodane


Chemical compound and disease context of iodane


Biological context of iodane


Anatomical context of iodane


Associations of iodane with other chemical compounds


Gene context of iodane

  • Experiments using IL-1 immobilized on Sepharose beads and soluble iodine 125 ((125)I)-labeled fibrinogen demonstrated no specific interaction of IL-1alpha with fibrinogen, but IL-1beta showed saturable and specific binding [32].
  • Binding studies using the 165 amino acid form of VEGF immobilized on Sepharose beads and soluble iodine 125 ((125)I)-labeled fibrinogen demonstrated saturable and specific binding [33].
  • Specificity of binding of mAb M195 was determined by protein-A red blood cell rosetting assays, immunoabsorption, radioimmunoassays with iodine-125 labeled M195 IgG and F(Ab)'2, and complement cytotoxicity with live human cells and cell lines representing a broad range of lineages and tissues [34].
  • In this study, the neuroanatomic distribution of CRF1 and CRF2 receptor binding sites in rhesus monkey (Macaca mulatta) was assessed by using iodine 125 ([125I)-Tyr0]-sauvagine with or without the selective CRF1 receptor antagonist CP-154,526-1 [35].
  • METHOD: Autoradiography with iodine 125-labeled ET-1 and varying concentrations of unlabeled ET-3 was used to localize ET receptor-binding subtypes in the posterior pole of human and rabbit eyes [36].

Analytical, diagnostic and therapeutic context of iodane

  • Binding of antibody to chromatograms is detected by autoradiography after the application of iodine-125-labeled F(ab')2 of rabbit immunoglobulin G antibodies to mouse immunoglobulins [37].
  • The diagnosis of DVT was established by an uptake test using fibrinogen labeled with iodine 125; in patients undergoing hip replacement, phlebography was also employed to confirm or refute the presence of isotopic thrombi [38].
  • The treatment protocol involved surgery, partial brain external-beam radiotherapy (59.4 Gy in 33 fractions), and stereotactic brachytherapy with temporary high-activity iodine 125 sources giving an additional 50 Gy to the tumor bed [39].
  • A radioimmunoassay has been developed for detecting human schistosomiasis with a highly purified Schistosoma mansoni egg antigen labelled with iodine-125 [40].
  • At day 60, patients with at least stable disease received hyperfractionated (n = 9) or conventional external-beam radiotherapy (n = 2) preceded by local radioactive iodine 125 implantation (n = 2) or radiosurgery (n = 1) [41].


  1. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. Vernino, S., Low, P.A., Fealey, R.D., Stewart, J.D., Farrugia, G., Lennon, V.A. N. Engl. J. Med. (2000) [Pubmed]
  2. Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy. Ballou, B., Levine, G., Hakala, T.R., Solter, D. Science (1979) [Pubmed]
  3. Identifying patients at risk for thromboembolism. Use of 125I-labeled fibrinogen in patients with acute myocardial infarction. Cristal, N., Stern, J., Ronen, M., Silverman, C., Ho, W., Bartov, E. JAMA (1976) [Pubmed]
  4. Correlation of cytotoxicity with elimination of iodine-125 from nude mice inoculated with prelabeled human melanoma cells. Lockshin, A., Giovanella, B.C., Quian, C., Mendoza, J.T., Vardeman, D.M., Stehlin, J.S. J. Natl. Cancer Inst. (1984) [Pubmed]
  5. Induction of lung tumors by radioactive isotopes implanted in the rat lung. Kal, H.B., Zurcher, C., van Bekkum, D.W. J. Natl. Cancer Inst. (1986) [Pubmed]
  6. Long-term potency after iodine-125 radiotherapy for prostate cancer and role of sildenafil citrate. Raina, R., Agarwal, A., Goyal, K.K., Jackson, C., Ulchaker, J., Angermeier, K., Klein, E., Ciezki, J., Zippe, C.D. Urology (2003) [Pubmed]
  7. The insulin receptor contains a calmodulin-binding domain. Graves, C.B., Goewert, R.R., McDonald, J.M. Science (1985) [Pubmed]
  8. Receptor-mediated transport of insulin across endothelial cells. King, G.L., Johnson, S.M. Science (1985) [Pubmed]
  9. Blood-brain barrier: endogenous modulation by adrenal-cortical function. Long, J.B., Holaday, J.W. Science (1985) [Pubmed]
  10. Cholecystokinin receptors in the brain: characterization and distribution. Saito, A., Sankaran, H., Goldfine, I.D., Williams, J.A. Science (1980) [Pubmed]
  11. Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin A. Renston, R.H., Jones, A.L., Christiansen, W.D., Hradek, G.T., Underdown, B.J. Science (1980) [Pubmed]
  12. Hirudin, heparin, and placebo during deep arterial injury in the pig. The in vivo role of thrombin in platelet-mediated thrombosis. Heras, M., Chesebro, J.H., Webster, M.W., Mruk, J.S., Grill, D.E., Penny, W.J., Bowie, E.J., Badimon, L., Fuster, V. Circulation (1990) [Pubmed]
  13. Iodine 125 suture implants in the management of advanced tumors in the neck attached to the carotid artery. Paryani, S.B., Goffinet, D.R., Fee, W.E., Goode, R.L., Levine, P., Hopp, M.L. J. Clin. Oncol. (1985) [Pubmed]
  14. Accumulation of radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid in ischemic myocardium during acute coronary occlusion and reperfusion. Bianco, J.A., Pape, L.A., Alpert, J.S., Zheng, M., Hnatowich, D., Goodman, M.M., Knapp, F.F. J. Am. Coll. Cardiol. (1984) [Pubmed]
  15. Concurrent cisplatin therapy and iodine 125 brachytherapy for recurrent malignant brain tumors. Chamberlain, M.C., Barba, D., Kormanik, P., Berson, A.M., Saunders, W.M., Shea, M.C. Arch. Neurol. (1995) [Pubmed]
  16. Comparison of copper-67- and iodine-125-labeled anti-CEA monoclonal antibody biodistribution in patients with colorectal tumors. Delaloye, A.B., Delaloye, B., Buchegger, F., Vogel, C.A., Gillet, M., Mach, J.P., Smith, A., Schubiger, P.A. J. Nucl. Med. (1997) [Pubmed]
  17. Enhancement of metastatic potential of murine and human melanoma cells by laminin receptor peptide G: attachment of cancer cells to subendothelial matrix as a pathway for hematogenous metastasis. Taraboletti, G., Belotti, D., Giavazzi, R., Sobel, M.E., Castronovo, V. J. Natl. Cancer Inst. (1993) [Pubmed]
  18. Radioactive iodine-125 and iodine-129 derived from environmental pollution in members of the public. Bowlt, C., Howe, J.R. Lancet (1985) [Pubmed]
  19. High-dose atrial natriuretic factor enhances albumin escape from the systemic but not the pulmonary circulation. Zimmerman, R.S., Trippodo, N.C., MacPhee, A.A., Martinez, A.J., Barbee, R.W. Circ. Res. (1990) [Pubmed]
  20. Enhancement of monoclonal antibody uptake in human colon tumor xenografts following irradiation. Kalofonos, H., Rowlinson, G., Epenetos, A.A. Cancer Res. (1990) [Pubmed]
  21. Phase I/II study of iodine 125-labeled monoclonal antibody A33 in patients with advanced colon cancer. Welt, S., Scott, A.M., Divgi, C.R., Kemeny, N.E., Finn, R.D., Daghighian, F., Germain, J.S., Richards, E.C., Larson, S.M., Old, L.J. J. Clin. Oncol. (1996) [Pubmed]
  22. Entry of insulin into human cultured lymphocytes: electron microscope autoradiographic analysis. Goldfine, I.D., Jones, A.L., Hradek, G.T., Wong, K.Y., Mooney, J.S. Science (1978) [Pubmed]
  23. Intracellular translocation of iodine-125-labeled insulin: direct demonstration in isolated hepatocytes. Gorden, P., Carpentier, J.L., Freychet, P., LeCam, A., Orci, L. Science (1978) [Pubmed]
  24. Neuraminidase-augmented anticarcinoembryonic antigen (CEA)-complement lysis of human colon tumor cells: lack of correlation with anti-CEA-mediated K-cell lysis and iodine-125 binding. Tompkins, W.A., Schmale, J.D., Mock, R., Tick, N.T., Lock, T., Sidell, N., Palmer, J.L. J. Natl. Cancer Inst. (1979) [Pubmed]
  25. Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice. Aboud-Pirak, E., Hurwitz, E., Pirak, M.E., Bellot, F., Schlessinger, J., Sela, M. J. Natl. Cancer Inst. (1988) [Pubmed]
  26. Carcinoma of trachea following iodine-125 therapy for thyrotoxicosis. Gray, H.W., McKillop, J.H., McGurk, F.M., Davidson, K.G., Doig, J.A., Gillespie, F.C. Lancet (1982) [Pubmed]
  27. Effect of transmural pressure on low density lipoprotein and albumin transport and distribution across the intact arterial wall. Curmi, P.A., Juan, L., Tedgui, A. Circ. Res. (1990) [Pubmed]
  28. Parenchymal and nonparenchymal uptake of technetium-99m, indium-111, and iodine-125 low-density lipoprotein in the normal and estradiol-stimulated rat liver: tracer validation for quantitative low-density lipoprotein scintigraphy. Leitha, T., Staudenherz, A., Hermann, M., Hüttinger, M., Gmeiner, B. Hepatology (1995) [Pubmed]
  29. Two-color cytofluorometry and cellular properties of the urokinase receptor associated with a human metastatic carcinomatous cell line. Takahashi, K., Gojobori, T., Tanifuji, M. Exp. Cell Res. (1991) [Pubmed]
  30. A new approach to the integrity of dual blood-brain barrier functions of global ischemic rats. Barrier and carrier functions. Yoshizumi, H., Fujibayashi, Y., Kikuchi, H. Stroke (1993) [Pubmed]
  31. Preparation of iodine-125-labeled insulin for radioimmunoassay: comparison of lactoperoxidase and chloramine-T iodination. Wajchenberg, B.L., Pinto, H., Torres de Toledo e Souza, I., Lerário, A.C., Ribeiro Pieroni, R. J. Nucl. Med. (1978) [Pubmed]
  32. Interleukin-1beta but not IL-1alpha binds to fibrinogen and fibrin and has enhanced activity in the bound form. Sahni, A., Guo, M., Sahni, S.K., Francis, C.W. Blood (2004) [Pubmed]
  33. Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation. Sahni, A., Francis, C.W. Blood (2000) [Pubmed]
  34. Restricted expression of an early myeloid and monocytic cell surface antigen defined by monoclonal antibody M195. Tanimoto, M., Scheinberg, D.A., Cordon-Cardo, C., Huie, D., Clarkson, B.D., Old, L.J. Leukemia (1989) [Pubmed]
  35. Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain. Sánchez, M.M., Young, L.J., Plotsky, P.M., Insel, T.R. J. Comp. Neurol. (1999) [Pubmed]
  36. Endothelin receptor-binding subtypes in the human retina and choroid. MacCumber, M.W., D'Anna, S.A. Arch. Ophthalmol. (1994) [Pubmed]
  37. A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma. Magnani, J.L., Brockhaus, M., Smith, D.F., Ginsburg, V., Blaszczyk, M., Mitchell, K.F., Steplewski, Z., Koprowski, H. Science (1981) [Pubmed]
  38. Prophylaxis for postoperative deep-vein thrombosis. Synergistic effect of heparin and dihydroergotamine. Kakkar, V.V., Stamatakis, J.D., Bentley, P.G., Lawrence, D., de Haas, H.A., Ward, V.P. JAMA (1979) [Pubmed]
  39. Results of stereotactic brachytherapy used in the initial management of patients with glioblastoma. Loeffler, J.S., Alexander, E., Wen, P.Y., Shea, W.M., Coleman, C.N., Kooy, H.M., Fine, H.A., Nedzi, L.A., Silver, B., Riese, N.E. J. Natl. Cancer Inst. (1990) [Pubmed]
  40. Purified antigen radioimmunoassay in serological diagnosis of schistosomiasis mansoni. Pelley, R.P., Warren, K.S., Jordan, P. Lancet (1977) [Pubmed]
  41. High-dose chemotherapy and autologous bone marrow rescue followed by interstitial and external-beam radiotherapy in newly diagnosed pediatric malignant gliomas. Heideman, R.L., Douglass, E.C., Krance, R.A., Fontanesi, J., Langston, J.A., Sanford, R.A., Kovnar, E.H., Ochs, J., Kuttesch, J., Jenkins, J.J. J. Clin. Oncol. (1993) [Pubmed]
WikiGenes - Universities