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Chemical Compound Review

AC1L2WXQ     ethyl4-[3-[1-(6- methylpyridazin-3-yl)-4...

Synonyms: DB08013, R-78206, R78206, R 78206, 124436-97-1
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Disease relevance of R-78206

  • R 78206 (a pyridazinamine derivative) inhibits the formation of poliovirus eclipse particles [1].
  • The minimum concentrations required for full stabilization at 46 degrees C (1.0 microM for WIN 51711, 0.2 microM for R 78206) were independent of the strain or serotype of the virus; 30 to 60 molecules of stabilizer per virion were required for full protection [2].


  1. Effect of a capsid-stabilizing pyridazinamine, R 78206, on the eclipse and intracellular location of poliovirus. Ofori-Anyinam, O., Vrijsen, R., Kronenberger, P., Boeyé, A. J. Virol. (1993) [Pubmed]
  2. A comparison of WIN 51711 and R 78206 as stabilizers of poliovirus virions and procapsids. Rombaut, B., Andries, K., Boeyé, A. J. Gen. Virol. (1991) [Pubmed]
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