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Chemical Compound Review:

AC1L2WXQ ethyl4-[3-[1-(6- methylpyridazin-3-yl)-4...

Synonyms: DB08013, R-78206, R78206, R 78206, 124436-97-1

Rombaut, B. et al., Ofori-Anyinam, O. et al.

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Disease relevance of R-78206

R 78206 (a pyridazinamine derivative) inhibits the formation of poliovirus eclipse particles [1].
The minimum concentrations required for full stabilization at 46 degrees C (1.0 microM for WIN 51711, 0.2 microM for R 78206) were independent of the strain or serotype of the virus; 30 to 60 molecules of stabilizer per virion were required for full protection [2].

References

Effect of a capsid-stabilizing pyridazinamine, R 78206, on the eclipse and intracellular location of poliovirus. Ofori-Anyinam, O., Vrijsen, R., Kronenberger, P., Boeyé, A. J. Virol. (1993) [Pubmed]
A comparison of WIN 51711 and R 78206 as stabilizers of poliovirus virions and procapsids. Rombaut, B., Andries, K., Boeyé, A. J. Gen. Virol. (1991) [Pubmed]

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