The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Poliovirus


High impact information on Poliovirus

  • Inhibition of cellular translation by these two viruses is quite similar, except that whereas CBP complex is proteolytically degraded by poliovirus, it is functionally inactivated by Ad [6].
  • The intrathecal synthesis of IgM antibodies to poliovirus correlated with the cerebrospinal fluid concentrations of interleukin-2 (P less than 0.0005) and soluble interleukin-2 receptors (P less than 0.001) [7].
  • Transgenic mice expressing human PVR should be useful for studying poliovirus neurovirulence, attenuation, and tissue tropism, and for development and testing of poliovirus vaccine strains [8].
  • These results demonstrate that the PVR is the major determinant of poliovirus host range in mice [8].
  • We conclude that poliovirus encodes the second proteinase 2A, which processes the polyprotein at tyrosine-glycine cleavage sites [9].

Chemical compound and disease context of Poliovirus

  • Studies on the function of polyadenylic acid on poliovirus RNA [10].
  • Large unilamellar vesicles (LUV) composed of phosphatidylserine are capable of encapsulating poliovirus ribonucleic acid (RNA) and delivering it efficiently to cells in an infectious form [11].
  • Ribavirin reduces infectious poliovirus production to as little as 0 [12].
  • The central portion (region P) of the 742-nucleotide noncoding 5' end of poliovirus allows the RNA to initiate protein synthesis in the absence of the usual 5' 7-methylguanosine capping group [13].
  • When inserted into two selected sites of LamB, a foreign antigen, the C3 epitope from poliovirus, was exposed at the cell surface with its normal antigenic properties [14].

Biological context of Poliovirus


Anatomical context of Poliovirus


Gene context of Poliovirus

  • Moreover, IFN-stimulated transcription was resistant to poliovirus-targeted degradation by TBP, and continued despite host-cell transcriptional shutoff during poliovirus infection [24].
  • We conclude that a non-classical transcriptional mechanism combats an anticellular action of poliovirus, through a TBP-free TAF-containing complex and GCN5 [24].
  • Specific interaction between recombinant PCBP2 and poliovirus stem-loop IV was demonstrated by RNA mobility shift analysis [25].
  • CD155, the cognate receptor for poliovirus, undergoes cell-matrix contacts by binding to the extracellular matrix protein vitronectin [26].
  • The N-terminal K homology domain of the poly(rC)-binding protein is a major determinant for binding to the poliovirus 5'-untranslated region and acts as an inhibitor of viral translation [27].

Analytical, diagnostic and therapeutic context of Poliovirus


  1. Myristylation of picornavirus capsid protein VP4 and its structural significance. Chow, M., Newman, J.F., Filman, D., Hogle, J.M., Rowlands, D.J., Brown, F. Nature (1987) [Pubmed]
  2. Human histocompatibility determinants and virus antigens: effect of measles virus infection on HLA expression. Haspel, M.V., Pellegrino, M.A., Lampert, P.W., Oldstone, M.B. J. Exp. Med. (1977) [Pubmed]
  3. Interaction of the poliovirus receptor with poliovirus. He, Y., Bowman, V.D., Mueller, S., Bator, C.M., Bella, J., Peng, X., Baker, T.S., Wimmer, E., Kuhn, R.J., Rossmann, M.G. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Gingras, A.C., Svitkin, Y., Belsham, G.J., Pause, A., Sonenberg, N. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. In vitro synthesis of infectious poliovirus RNA. Kaplan, G., Lubinski, J., Dasgupta, A., Racaniello, V.R. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  6. Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein. Huang, J.T., Schneider, R.J. Cell (1991) [Pubmed]
  7. Intrathecal immune response in patients with the post-polio syndrome. Sharief, M.K., Hentges, R., Ciardi, M. N. Engl. J. Med. (1991) [Pubmed]
  8. Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. Ren, R.B., Costantini, F., Gorgacz, E.J., Lee, J.J., Racaniello, V.R. Cell (1990) [Pubmed]
  9. A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein. Toyoda, H., Nicklin, M.J., Murray, M.G., Anderson, C.W., Dunn, J.J., Studier, F.W., Wimmer, E. Cell (1986) [Pubmed]
  10. Studies on the function of polyadenylic acid on poliovirus RNA. Spector, D.H., Villa-Komaroff, L., Baltimore, D. Cell (1975) [Pubmed]
  11. The introduction of poliovirus RNA into cells via lipid vesicles (liposomes). Wilson, T., Papahadjopoulos, D., Taber, R. Cell (1979) [Pubmed]
  12. The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Crotty, S., Maag, D., Arnold, J.J., Zhong, W., Lau, J.Y., Hong, Z., Andino, R., Cameron, C.E. Nat. Med. (2000) [Pubmed]
  13. Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region. Trono, D., Pelletier, J., Sonenberg, N., Baltimore, D. Science (1988) [Pubmed]
  14. Probing the topology of a bacterial membrane protein by genetic insertion of a foreign epitope; expression at the cell surface. Charbit, A., Boulain, J.C., Ryter, A., Hofnung, M. EMBO J. (1986) [Pubmed]
  15. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Mendelsohn, C.L., Wimmer, E., Racaniello, V.R. Cell (1989) [Pubmed]
  16. A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system. Castelli, J.C., Hassel, B.A., Wood, K.A., Li, X.L., Amemiya, K., Dalakas, M.C., Torrence, P.F., Youle, R.J. J. Exp. Med. (1997) [Pubmed]
  17. Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor. Mahon, B.P., Katrak, K., Nomoto, A., Macadam, A.J., Minor, P.D., Mills, K.H. J. Exp. Med. (1995) [Pubmed]
  18. RNA virus error catastrophe: direct molecular test by using ribavirin. Crotty, S., Cameron, C.E., Andino, R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  19. A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity. Pfeiffer, J.K., Kirkegaard, K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  20. Poliovirus proteinase 3C converts an active form of transcription factor IIIC to an inactive form: a mechanism for inhibition of host cell polymerase III transcription by poliovirus. Clark, M.E., Hämmerle, T., Wimmer, E., Dasgupta, A. EMBO J. (1991) [Pubmed]
  21. Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells. McBride, A.E., Schlegel, A., Kirkegaard, K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  22. Translation of eukaryotic translation initiation factor 4GI (eIF4GI) proceeds from multiple mRNAs containing a novel cap-dependent internal ribosome entry site (IRES) that is active during poliovirus infection. Byrd, M.P., Zamora, M., Lloyd, R.E. J. Biol. Chem. (2005) [Pubmed]
  23. Control by Ig genes of the responsiveness to a neutralization viral B cell epitope. Leclerc, C., Martineau, P., Charlot, B., Delpeyroux, F., van der Werf, S., Hofnung, M. J. Immunol. (1997) [Pubmed]
  24. IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff. Paulson, M., Press, C., Smith, E., Tanese, N., Levy, D.E. Nat. Cell Biol. (2002) [Pubmed]
  25. Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry. Blyn, L.B., Swiderek, K.M., Richards, O., Stahl, D.C., Semler, B.L., Ehrenfeld, E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  26. Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains. Mueller, S., Wimmer, E. J. Biol. Chem. (2003) [Pubmed]
  27. The N-terminal K homology domain of the poly(rC)-binding protein is a major determinant for binding to the poliovirus 5'-untranslated region and acts as an inhibitor of viral translation. Silvera, D., Gamarnik, A.V., Andino, R. J. Biol. Chem. (1999) [Pubmed]
  28. Heterogeneous expression of poliovirus receptor-related proteins in human cells and tissues. Freistadt, M.S., Kaplan, G., Racaniello, V.R. Mol. Cell. Biol. (1990) [Pubmed]
  29. Expression of poliovirus nonstructural proteins in Escherichia coli cells. Modification of membrane permeability induced by 2B and 3A. Lama, J., Carrasco, L. J. Biol. Chem. (1992) [Pubmed]
  30. Two distinct binding affinities of poliovirus for its cellular receptor. McDermott, B.M., Rux, A.H., Eisenberg, R.J., Cohen, G.H., Racaniello, V.R. J. Biol. Chem. (2000) [Pubmed]
  31. Enzymatic activity of poliovirus RNA polymerases with mutations at the tyrosine residue of the conserved YGDD motif: isolation and characterization of polioviruses containing RNA polymerases with FGDD and MGDD sequences. Jablonski, S.A., Morrow, C.D. J. Virol. (1993) [Pubmed]
WikiGenes - Universities