Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-004TO1 dimethoxyphosphinic acid

Synonyms: NSC-2676, AG-E-74545, NSC2676, LS-1814, NSC-289396, ...

Roy, S. et al., Lee, C.H. et al.

Roy, Roy, Kumar, Sharma, Pereira,

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Disease relevance of dimethoxyphosphinic acid

These metabolites were separated and purified to homogenity by HPLC and characterized by IR spectroscopy as O,O-dimethyl-O-(3-methyl-4-amino phenyl) phsophorothioate (metabolite 1), O,O-dimethyl phosphorothioate (metabolite II) and O,O-dimethyl phosphate (metabolite III) in the fi rst dose (5 mg/100 g body weight) [1].

High impact information on dimethoxyphosphinic acid

This resulted in a significant positive correlation between 8-OHdG levels and urinary DMP or DAP, suggesting a correlation between OP metabolites and production of oxidative stress [2].

References

Biodegradation and bioaccumulation of fenitrothion in rat liver. Roy, S., Roy, S., Kumar, R., Sharma, C.B., Pereira, B.J. Biomed. Chromatogr. (2004) [Pubmed]
8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype. Lee, C.H., Kamijima, M., Kim, H., Shibata, E., Ueyama, J., Suzuki, T., Takagi, K., Saito, I., Gotoh, M., Hibi, H., Naito, H., Nakajima, T. International archives of occupational and environmental health (2007) [Pubmed]

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