Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Cercosporamide (9aS)-8-ethanoyl-1,3,7- trihydroxy-9a...

Synonyms: CHEMBL475816, CHEBI:575975, CTK8E7014, DNC009370, AC1L2Z33, ...

Sussman, A. et al., Hong, Z. et al.

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High impact information on Cercosporamide

One of these mutants, the knr4-1 mutant, displays a number of cell wall defects, including osmotic sensitivity; sensitivity to cercosporamide, a known antifungal agent; and resistance to Zymolyase, a (1,3)-beta-glucanase [1].
Together, the results demonstrate that cercosporamide acts selectively on Pkc1 kinase and, thus, they provide a molecular mechanism for its antifungal activity [2].
Furthermore, cercosporamide and a beta-1,3-glucan synthase inhibitor echinocandin analog, by targeting two different key components of the cell wall biosynthesis pathway, are highly synergistic in their antifungal activities [2].

References

Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis. Hong, Z., Mann, P., Brown, N.H., Tran, L.E., Shaw, K.J., Hare, R.S., DiDomenico, B. Mol. Cell. Biol. (1994) [Pubmed]
Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Sussman, A., Huss, K., Chio, L.C., Heidler, S., Shaw, M., Ma, D., Zhu, G., Campbell, R.M., Park, T.S., Kulanthaivel, P., Scott, J.E., Carpenter, J.W., Strege, M.A., Belvo, M.D., Swartling, J.R., Fischl, A., Yeh, W.K., Shih, C., Ye, X.S. Eukaryotic Cell (2004) [Pubmed]

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