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Chemical Compound Review:

Decyldiamine decane-1,10-diamine

Synonyms: Lopac-D14204, CHEMBL570383, D14204_ALDRICH, AG-G-42610, ACMC-209nnf, ...

Subramaniam, S. et al., Weiger, T.M. et al., Woodward, J.J. et al., Neurath, A.R. et al.

Weiger, Langer, Hermann,

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Disease relevance of Decyldiamine

Hydrophobic chromatography of hepatitis B surface antigen on 1,9-diaminononane or 1,10-diaminodecane linked to agarose [1].

High impact information on Decyldiamine

In single-channel recordings we found polyamines as well as diamines up to 1,10-diaminodecane to be ineffective in altering channel current amplitudes or kinetics [2].
There was no regional variability in the effects of the putative inverse agonist 1,10-diaminodecane, consistent with recent suggestions that this polyamine inhibits the NMDA receptor at a site distinct from the one at which polyamines act to enhance NMDA receptor function [3].
The putative polyamine inverse agonist 1,10-diaminodecane (DA10) dose-dependently inhibited NMDA-stimulated release with a calculated IC50 value of 33 microM [4].

References

Hydrophobic chromatography of hepatitis B surface antigen on 1,9-diaminononane or 1,10-diaminodecane linked to agarose. Neurath, A.R., Lerman, S., Chen, M., Prince, A.M. J. Gen. Virol. (1975) [Pubmed]
External action of di- and polyamines on maxi calcium-activated potassium channels: an electrophysiological and molecular modeling study. Weiger, T.M., Langer, T., Hermann, A. Biophys. J. (1998) [Pubmed]
Regional heterogeneity of polyamine effects on the N-methyl-D-aspartate receptor in rat brain. Subramaniam, S., McGonigle, P. J. Neurochem. (1993) [Pubmed]
Effects of the putative polyamine antagonists diethylenetriamine and 1,10-diaminodecane on N-methyl-D-aspartic acid-stimulated [3H]norepinephrine release from rat hippocampal slices. Woodward, J.J., Cueto, S. J. Pharmacol. Exp. Ther. (1993) [Pubmed]

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