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Chemical Compound Review

CHEMBL352949     N-(4-bromophenyl)-3-oxo-4,5- diphenyl...

Synonyms: ACMC-1C65U, AG-D-78605, SureCN8846957, CTK4C1465, KB-214417, ...
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High impact information on LY 262691

  • Systemic injection of CCK-8, of a selective CCK-A agonist, or of non-peptide CCK-B antagonists (CI-988 and LY-262691) enhanced olfactory recognition [1].
  • LY 288513, a selective CCKB receptor antagonist (0.01 mg/kg), prevented the increase in exploratory activity in the DSP-4-treated rats, but increased the exploratory activity of controls on the third exposure to the test situation [2].

Gene context of LY 262691

  • By contrast, the CCKB receptor antagnoists PD 135,158 (0.001-0.01, 1 mg/kg, i.p.) and LY 288513 (1 and 3 mg/kg, i.p.) significantly decreased avoidance distance when the rat was first placed in the test apparatus, an effect which is consistent with an anti-panic-like action [3].


  1. CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats. Lemaire, M., Böhme, G.A., Piot, O., Roques, B.P., Blanchard, J.C. Psychopharmacology (Berl.) (1994) [Pubmed]
  2. Impaired exploratory behaviour after DSP-4 treatment in rats: implications for the increased anxiety after noradrenergic denervation. Harro, J., Oreland, L., Vasar, E., Bradwejn, J. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1995) [Pubmed]
  3. CCK receptor antagonists in animal models of anxiety: comparison between exploration tests, conflict procedures and a model based on defensive behaviours. Griebel, G., Perrault, G., Sanger, D.J. Behavioural pharmacology. (1997) [Pubmed]
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