The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cckbr  -  cholecystokinin B receptor

Rattus norvegicus

Synonyms: CCK-B receptor, CCK-BR, CCK2-R, Cck2r, Cholecystokinin-2 receptor, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cckbr


Psychiatry related information on Cckbr


High impact information on Cckbr


Biological context of Cckbr


Anatomical context of Cckbr


Associations of Cckbr with chemical compounds


Physical interactions of Cckbr

  • The mutated receptor displayed similar expression levels and high affinity CCK binding compared with the wild type CCKBR [26].

Regulatory relationships of Cckbr

  • The results suggest that CCK antagonism of opioid-induced disruption of maternal behavior occurs due to the action of CCK on both CCK1 and CCK2 receptor subtypes [6].
  • We examined whether the CCK-A and CCK-B receptor genes are expressed in the islets and the role of CCK-A receptor in insulin secretion [27].
  • The results showed a good correlation between the binding of gastrin to CCKB receptor [Kd 1.125 +/- 0.3 (SD) nM] and its ability to either induce ornithine decarboxylase activity [50% effective concentration, 0.6 +/- 0.3 nM] and [3H]-thymidine incorporation [50% effective concentration, 2 +/- 0.4 nM] [28].
  • Blockade of gastrin/CCKB receptors partially inhibits intragastric meal-stimulated acid secretion indicating that the gastrin/CCKB receptor has a physiological role as mediator of food-stimulated acid secretory response in conscious rats [29].

Other interactions of Cckbr


Analytical, diagnostic and therapeutic context of Cckbr

  • METHODS: CCK-AR and CCK-BR mRNA expression and cellular distribution in the rat lung were detected by highly sensitive method of in situ reverse transcription-polymerase chain reaction (RT-PCR) and conventional in situ hybridization [22].
  • Southern blot analysis of RT-PCR amplified CCK-AR and CCK-BR mRNA products using [gamma-32P]ATP 5'-end-labelled probe showed specific hybridization bands [33].
  • 2. Intravenous injection of CAM-1481 (1 mg kg-1), a dipeptoid antagonist of CCKA receptors, or CAM-1028, a dipeptoid CCKB receptor antagonist (1 mg kg-1), had no effect on basal gastric mucosal blood flow as determined by the clearance of hydrogen in urethane-anaesthetized rats [34].
  • Hypophysectomy 5 days prior to sacrifice, resulting in a nerve lesion in the neurohypophysial pathway and removal of the anterior pituitary hormones, induced a significant increase in CCKB receptor mRNA levels in neurons of the PVN [35].
  • The response was not decreased by atropine, hexamethonium, vagotomy, a mixture of adrenoceptor antagonists (prazosin + idazoxan + propranolol), or by the CCKB receptor antagonist L365,260 [36].


  1. Spinal effect of the cholecystokinin-B receptor antagonist CI-988 on hyperalgesia, allodynia and morphine-induced analgesia in diabetic and mononeuropathic rats. Coudoré-Civiale, M.A., Courteix, C., Fialip, J., Boucher, M., Eschalier, A. Pain (2000) [Pubmed]
  2. Increased spinal cholecystokinin activity after systemic resiniferatoxin: electrophysiological and in situ hybridization studies. Broberger, C., Farkas-Szallasi, T., Szallasi, A., Lundberg, J.M., Hökfelt, T., Wiesenfeld-Hallin, Z., Xu, X.J. Pain (2000) [Pubmed]
  3. Prevention of tolerance to the antinociceptive effects of systemic morphine by a selective cholecystokinin-B receptor antagonist in a rat model of peripheral neuropathy. Idänpään-Heikkilä, J.J., Guilbaud, G., Kayser, V. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  4. Type B cholecystokinin receptors on rat glioma C6 cells. Binding studies and measurement of intracellular calcium mobilization. Kaufmann, R., Lindschau, C., Schöneberg, T., Haller, H., Henklein, P., Boomgaarden, M., Ott, T. Brain Res. (1994) [Pubmed]
  5. Cholecystokinin and thermoregulation--a minireview. Szelényi, Z. Peptides (2001) [Pubmed]
  6. Differential role of cholecystokinin receptor subtypes in opioid modulation of ongoing maternal behavior. Miranda-Paiva, C.M., Felicio, L.F. Pharmacol. Biochem. Behav. (1999) [Pubmed]
  7. Characterization of the role of endogenous cholecystokinin on the activity of the paraventricular nucleus of the hypothalamus in rats. Cano, V., Ezquerra, L., Ramos, M.P., Ruiz-Gayo, M. Br. J. Pharmacol. (2003) [Pubmed]
  8. Physiological disposition and metabolism of L-365,260, a potent antagonist of brain cholecystokinin receptor, in laboratory animals. Chen, I.W., Dorley, J.M., Ramjit, H.G., Pitzenberger, S.M., Lin, J.H. Drug Metab. Dispos. (1992) [Pubmed]
  9. Cholecystokinin-B receptor antagonists attenuate morphine dependence and withdrawal in rats. Lu, L., Huang, M., Liu, Z., Ma, L. Neuroreport (2000) [Pubmed]
  10. Effect of CCK1 and CCK2 receptor blockade on amphetamine-stimulated exploratory behavior and sensitization to amphetamine. Alttoa, A., Harro, J. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2004) [Pubmed]
  11. Central inhibitory dysfunctions: mechanisms and clinical implications. Wiesenfeld-Hallin, Z., Aldskogius, H., Grant, G., Hao, J.X., Hökfelt, T., Xu, X.J. The Behavioral and brain sciences. (1997) [Pubmed]
  12. A locus and mechanism of action for associative morphine tolerance. Mitchell, J.M., Basbaum, A.I., Fields, H.L. Nat. Neurosci. (2000) [Pubmed]
  13. Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue. Reubi, J.C., Waser, B., Gugger, M., Friess, H., Kleeff, J., Kayed, H., Büchler, M.W., Laissue, J.A. Gastroenterology (2003) [Pubmed]
  14. Mitogenic effect of gastrin and expression of gastrin receptors in duct-like cells of rat pancreas. Rooman, I., Lardon, J., Flamez, D., Schuit, F., Bouwens, L. Gastroenterology (2001) [Pubmed]
  15. Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression. Wank, S.A., Pisegna, J.R., de Weerth, A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  16. Paracrine stimulation of cell growth by cholecystokinin/gastrin through cholecystokinin-B receptor on GH3 cells in vitro. Xu, Y., Kaji, H., Okimura, Y., Matsui, T., Abe, H., Chihara, K. Neuroendocrinology (1996) [Pubmed]
  17. A novel role for cholecystokinin: regulation of mesenteric vascular resistance. Sánchez-Fernández, C., González, M.C., Beart, P.M., Mercer, L.D., Ruiz-Gayo, M., Fernández-Alfonso, M.S. Regul. Pept. (2004) [Pubmed]
  18. Cholecystokinin octapeptide improves cardiac function by activating cholecystokinin octapeptide receptor in endotoxic shock rats. Zhao, X.Y., Ling, Y.L., Li, Y.G., Meng, A.H., Xing, H.Y. World J. Gastroenterol. (2005) [Pubmed]
  19. Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats. Wu, C.L., Hung, C.R., Chang, F.Y., Pau, K.Y., Wang, J.L., Wang, P.S. Pflugers Arch. (2002) [Pubmed]
  20. Increased gastric acid secretion in cholecystokinin-1 receptor-deficient Otsuka Long-Evans Tokushima fatty rats. Kanagawa, K., Nakamura, H., Murata, I., Yosikawa, I., Otsuki, M. Scand. J. Gastroenterol. (2002) [Pubmed]
  21. Effects of cholecystokinin-receptor antagonists on Fos-like immunoreactivity stimulated by sulfated cholecystokinin-8 in neurons of the myenteric plexus and hindbrain of rats. Webb, T., Gulley, S., Esdaile, A.R., Pruitt, F., Sharma, S.K., Williams, C.S., Sayegh, A.I. Am. J. Vet. Res. (2005) [Pubmed]
  22. Expression and cell-specific localization of cholecystokinin receptors in rat lung. Cong, B., Li, S.J., Ling, Y.L., Yao, Y.X., Gu, Z.Y., Wang, J.X., You, H.Y. World J. Gastroenterol. (2003) [Pubmed]
  23. Evidence for an involvement of the brain cholecystokinin B receptor in anxiety. Singh, L., Lewis, A.S., Field, M.J., Hughes, J., Woodruff, G.N. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  24. The excitatory effect of cholecystokinin on rat neostriatal neurons: ionic and molecular mechanisms. Wu, T., Wang, H.L. Eur. J. Pharmacol. (1996) [Pubmed]
  25. The effects of intrathecally administered FK480, a cholecystokinin-A receptor antagonist, and YM022, a cholecystokinin-B receptor antagonist, on the formalin test in the rat. Yamamoto, T., Nozaki-Taguchi, N. Anesth. Analg. (1996) [Pubmed]
  26. Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptor. Galés, C., Kowalski-Chauvel, A., Dufour, M.N., Seva, C., Moroder, L., Pradayrol, L., Vaysse, N., Fourmy, D., Silvente-Poirot, S. J. Biol. Chem. (2000) [Pubmed]
  27. Pancreatic endocrine dysfunction in rats not expressing the cholecystokinin-A receptor. Funakoshi, A., Miyasaka, K., Kanai, S., Masuda, M., Yasunami, Y., Nagai, T., Ikeda, S., Jimi, A., Kawanami, T., Kono, A. Pancreas (1996) [Pubmed]
  28. Lorglumide and loxiglumide inhibit gastrin-stimulated DNA synthesis in a rat tumoral acinar pancreatic cell line (AR42J). Seva, C., Scemama, J.L., Bastié, M.J., Pradayrol, L., Vaysse, N. Cancer Res. (1990) [Pubmed]
  29. Role of gastrin and cholecystokinin receptors in regulation of peptone-stimulated gastric acid secretion in conscious rats. Varga, G., Campbell, D.R., Bussjaeger, L.J., Solomon, T.E. Eur. J. Pharmacol. (1993) [Pubmed]
  30. Regulation of rat pancreatic CCKB receptor and somatostatin expression by insulin. Julien, S., Laine, J., Morisset, J. Diabetes (2004) [Pubmed]
  31. Anti-inflammatory effects of leptin and cholecystokinin on acetic acid-induced colitis in rats: role of capsaicin-sensitive vagal afferent fibers. Bozkurt, A., Cakir, B., Ercan, F., Yeğen, B.C. Regul. Pept. (2003) [Pubmed]
  32. Anti-inflammatory effect of acute stress on experimental colitis is mediated by cholecystokinin-B receptors. Gülpinar, M.A., Ozbeyli, D., Arbak, S., Yeğen, B.C. Life Sci. (2004) [Pubmed]
  33. Effect of lipopolysaccharide on expression and characterization of cholecystokinin receptors in rat pulmonary interstitial macrophages. Xu, S.J., Gao, W.J., Cong, B., Yao, Y.X., Gu, Z.Y. Acta Pharmacol. Sin. (2004) [Pubmed]
  34. Mediation by CCKB receptors of the CCK-evoked hyperaemia in rat gastric mucosa. Heinemann, A., Jocic, M., Holzer-Petsche, U., Pethö, G., Peskar, B.M., Horwell, D.C., Holzer, P. Br. J. Pharmacol. (1995) [Pubmed]
  35. Cholecystokinin B receptor gene expression in hypothalamic neurosecretory neurons after experimental manipulations. Meister, B., Broberger, C., Villar, M.J., Hökfelt, T. Neuroendocrinology (1994) [Pubmed]
  36. Modulation of pancreatic secretion by capsaicin-sensitive sensory neurons in the rat. Gicquel, N., Nagain, C., Chariot, J., Tsocas, A., Levenez, F., Corring, T., Rozé, C. Pancreas (1994) [Pubmed]
WikiGenes - Universities