Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Piv2 ddump [2,2- dimethylpropanoyloxymethoxy- [[(2S,5R)...

Synonyms: NSC685583, AC1L31C5, (Pom)2-N3UMP, Bis(PivOCH2)ddUMP

Sastry, J.K. et al.

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Disease relevance of AIDS003944

In contrast, phosphorylated metabolites were not observed in cells treated with ddU or ddUMP alone. piv2-ddUMP also reduced the cytopathic effects of HIV-1 in MT-4 cells (ED50, 4.75 microM) and inhibited virus production in culture fluid (ED50, 20 microM) [1].

High impact information on AIDS003944

The 5'-mono-, di-, and triphosphates of ddU were formed in both cell lines after exposure to piv2-ddUMP [1].
In addition, piv2-ddUMP protected CEM-tk- cells from HIV-1 infection, as demonstrated by inhibition of intracellular p24 antigen levels (ED50, 3 microM) and reverse transcriptase activity in culture medium (Ed50, 2.5 microM) [1].

References

Membrane-permeable dideoxyuridine 5'-monophosphate analogue inhibits human immunodeficiency virus infection. Sastry, J.K., Nehete, P.N., Khan, S., Nowak, B.J., Plunkett, W., Arlinghaus, R.B., Farquhar, D. Mol. Pharmacol. (1992) [Pubmed]

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