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Chemical Compound Review:

SureCN370332 [(3S,10R,13S)-10,13-dimethyl- 17-pyridin-3...

Synonyms: CB-7630, KB-47026, LS-182008, FT-0660946, AC1L31XC, ...

O'Donnell, A. et al., Martins, V. et al., Haidar, S. et al.

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Disease relevance of CB-7630

Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer [1].

High impact information on CB-7630

Male Sprague-Dawley (SD) rats were administered daily for 14 days BW 19 and the acetyl derivatives Sa 41 and CB 7630 as prodrugs (0.1 mmol/kg intraperitoneally) [2].
A validated liquid chromatographic-tandem mass spectroscopy method for the quantification of abiraterone acetate and abiraterone in human plasma [3].

Chemical compound and disease context of CB-7630

A series of three dose escalating studies were conducted to investigate the ability of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate, to cause maximum suppression of testosterone synthesis when delivered to castrate and noncastrate males with prostate cancer [1].
This method will be applied to a clinical trial investigating the pharmacokinetics of abiraterone acetate and abiraterone in patients with prostate cancer [3].

References

Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. O'Donnell, A., Judson, I., Dowsett, M., Raynaud, F., Dearnaley, D., Mason, M., Harland, S., Robbins, A., Halbert, G., Nutley, B., Jarman, M. Br. J. Cancer (2004) [Pubmed]
Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo. Haidar, S., Ehmer, P.B., Barassin, S., Batzl-Hartmann, C., Hartmann, R.W. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
A validated liquid chromatographic-tandem mass spectroscopy method for the quantification of abiraterone acetate and abiraterone in human plasma. Martins, V., Asad, Y., Wilsher, N., Raynaud, F. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2006) [Pubmed]

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