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MeSH Review

Clinical Trial [Publication Type]

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Disease relevance of Clinical Trial [Publication Type]


Psychiatry related information on Clinical Trial [Publication Type]


High impact information on Clinical Trial [Publication Type]

  • In this article, clinical trial data on a number of alternative cancer cures including Livingston-Wheeler, Di Bella Multitherapy, antineoplastons, vitamin C, hydrazine sulfate, Laetrile, and psychotherapy are reviewed [11].
  • A clinical trial of estrogen-replacement therapy after ischemic stroke [12].
  • METHODS: Levels of C-reactive protein and fibrinogen at enrollment and the maximal level of troponin T during the first 24 hours after enrollment were analyzed in 917 patients included in a clinical trial of low-molecular-weight heparin in unstable coronary artery disease [13].
  • We conducted a clinical trial to assess the efficacy of treatment with a combination of interferon and cytarabine [14].
  • In a double-blind, randomized clinical trial, we tested the efficacy of hydroxyurea in reducing the frequency of painful crises in adults with a history of three or more such crises per year [15].

Chemical compound and disease context of Clinical Trial [Publication Type]


Biological context of Clinical Trial [Publication Type]


Anatomical context of Clinical Trial [Publication Type]


Associations of Clinical Trial [Publication Type] with chemical compounds


Gene context of Clinical Trial [Publication Type]

  • Here we demonstrate that the nonsynonymous variation in TBX21 coding for replacement of histidine 33 with glutamine is associated with significant improvement in the PC(20) (a measure of airway responsiveness) of asthmatic children in a large clinical trial spanning 4 years [36].
  • Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia [37].
  • We also observed increased expression of C/EBPalpha and PU.1 accompanied by signs of differentiation in 2 of 3 primary AML samples from patients with FLT3/ITD mutations receiving a FLT3 inhibitor, CEP-701, as part of a clinical trial [38].
  • To determine the frequency and clinical significance of MDR1, MRP1, and LRP in younger AML patients, we developed multiparameter flow cytometric assays to quantify expression of these proteins in pretreatment leukemic blasts from 352 newly diagnosed AML patients (median age, 44 years) registered to a single clinical trial (SWOG 8600) [39].
  • Randomized placebo-controlled clinical trial of high-dose interleukin-2 in combination with a soluble p75 tumor necrosis factor receptor immunoglobulin G chimera in patients with advanced melanoma and renal cell carcinoma [40].

Analytical, diagnostic and therapeutic context of Clinical Trial [Publication Type]


  1. Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer. Ingle, J.N., Ahmann, D.L., Green, S.J., Edmonson, J.H., Bisel, H.F., Kvols, L.K., Nichols, W.C., Creagan, E.T., Hahn, R.G., Rubin, J., Frytak, S. N. Engl. J. Med. (1981) [Pubmed]
  2. The effects of antihypertensive therapy on the quality of life. Croog, S.H., Levine, S., Testa, M.A., Brown, B., Bulpitt, C.J., Jenkins, C.D., Klerman, G.L., Williams, G.H. N. Engl. J. Med. (1986) [Pubmed]
  3. A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group. Køber, L., Torp-Pedersen, C., Carlsen, J.E., Bagger, H., Eliasen, P., Lyngborg, K., Videbaek, J., Cole, D.S., Auclert, L., Pauly, N.C. N. Engl. J. Med. (1995) [Pubmed]
  4. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. Eschbach, J.W., Egrie, J.C., Downing, M.R., Browne, J.K., Adamson, J.W. N. Engl. J. Med. (1987) [Pubmed]
  5. Recombinant interferon alfa-2b combined with a regimen containing doxorubicin in patients with advanced follicular lymphoma. Groupe d'Etude des Lymphomes de l'Adulte. Solal-Celigny, P., Lepage, E., Brousse, N., Reyes, F., Haioun, C., Leporrier, M., Peuchmaur, M., Bosly, A., Parlier, Y., Brice, P. N. Engl. J. Med. (1993) [Pubmed]
  6. Heavy smokers, smoking cessation, and clonidine. Results of a double-blind, randomized trial. Glassman, A.H., Stetner, F., Walsh, B.T., Raizman, P.S., Fleiss, J.L., Cooper, T.B., Covey, L.S. JAMA (1988) [Pubmed]
  7. Use of disulfiram for alcoholics in methadone maintenance programs. A Veterans Administration Cooperative Study. Ling, W., Weiss, D.G., Charuvastra, V.C., O'Brien, C.P. Arch. Gen. Psychiatry (1983) [Pubmed]
  8. The National Institute on Drug Abuse Collaborative Cocaine Treatment Study. Rationale and methods. Crits-Christoph, P., Siqueland, L., Blaine, J., Frank, A., Luborsky, L., Onken, L.S., Muenz, L., Thase, M.E., Weiss, R.D., Gastfriend, D.R., Woody, G., Barber, J.P., Butler, S.F., Daley, D., Bishop, S., Najavits, L.M., Lis, J., Mercer, D., Griffin, M.L., Moras, K., Beck, A.T. Arch. Gen. Psychiatry (1997) [Pubmed]
  9. Treatment of secondary depression in schizophrenia. A double-blind, placebo-controlled trial of amitriptyline added to perphenazine. Prusoff, B.A., Williams, D.H., Weissman, M.M., Astrachan, B.M. Arch. Gen. Psychiatry (1979) [Pubmed]
  10. Isoniazid-induced elevation of CSF GABA levels and effects on chorea in Huntington's disease. Manyam, B.V., Katz, L., Hare, T.A., Kaniefski, K., Tremblay, R.D. Ann. Neurol. (1981) [Pubmed]
  11. Alternative cancer cures: "unproven" or "disproven"? Vickers, A. CA: a cancer journal for clinicians. (2004) [Pubmed]
  12. A clinical trial of estrogen-replacement therapy after ischemic stroke. Viscoli, C.M., Brass, L.M., Kernan, W.N., Sarrel, P.M., Suissa, S., Horwitz, R.I. N. Engl. J. Med. (2001) [Pubmed]
  13. Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease. Lindahl, B., Toss, H., Siegbahn, A., Venge, P., Wallentin, L. N. Engl. J. Med. (2000) [Pubmed]
  14. Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia. French Chronic Myeloid Leukemia Study Group. Guilhot, F., Chastang, C., Michallet, M., Guerci, A., Harousseau, J.L., Maloisel, F., Bouabdallah, R., Guyotat, D., Cheron, N., Nicolini, F., Abgrall, J.F., Tanzer, J. N. Engl. J. Med. (1997) [Pubmed]
  15. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. Charache, S., Terrin, M.L., Moore, R.D., Dover, G.J., Barton, F.B., Eckert, S.V., McMahon, R.P., Bonds, D.R. N. Engl. J. Med. (1995) [Pubmed]
  16. Ondansetron compared with dexamethasone and metoclopramide as antiemetics in the chemotherapy of breast cancer with cyclophosphamide, methotrexate, and fluorouracil. Levitt, M., Warr, D., Yelle, L., Rayner, H.L., Lofters, W.S., Perrault, D.J., Wilson, K.S., Latreille, J., Potvin, M., Warner, E. N. Engl. J. Med. (1993) [Pubmed]
  17. A clinical trial of beta carotene to prevent basal-cell and squamous-cell cancers of the skin. The Skin Cancer Prevention Study Group. Greenberg, E.R., Baron, J.A., Stukel, T.A., Stevens, M.M., Mandel, J.S., Spencer, S.K., Elias, P.M., Lowe, N., Nierenberg, D.W., Bayrd, G. N. Engl. J. Med. (1990) [Pubmed]
  18. Phenytoin therapy of recessive dystrophic epidermolysis bullosa. Clinical trial and proposed mechanism of action on collagenase. Bauer, E.A., Cooper, T.W., Tucker, D.R., Esterly, N.B. N. Engl. J. Med. (1980) [Pubmed]
  19. Reversal of adriamycin resistance by verapamil in human ovarian cancer. Rogan, A.M., Hamilton, T.C., Young, R.C., Klecker, R.W., Ozols, R.F. Science (1984) [Pubmed]
  20. An assessment of diltiazem and hydrochlorothiazide in hypertension. Application of factorial trial design to a multicenter clinical trial of combination therapy. Burris, J.F., Weir, M.R., Oparil, S., Weber, M., Cady, W.J., Stewart, W.H. JAMA (1990) [Pubmed]
  21. Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers. Jäger, E., Gnjatic, S., Nagata, Y., Stockert, E., Jäger, D., Karbach, J., Neumann, A., Rieckenberg, J., Chen, Y.T., Ritter, G., Hoffman, E., Arand, M., Old, L.J., Knuth, A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  22. Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro. Oehler, L., Jaeger, E., Eser, A., Sillaber, C., Gisslinger, H., Geissler, K. Blood (2003) [Pubmed]
  23. Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized, crossover trial. Struck, R.F., Alberts, D.S., Horne, K., Phillips, J.G., Peng, Y.M., Roe, D.J. Cancer Res. (1987) [Pubmed]
  24. A randomized clinical trial of ursodeoxycholic acid as adjuvant treatment to prevent liver transplant rejection. Barnes, D., Talenti, D., Cammell, G., Goormastic, M., Farquhar, L., Henderson, M., Vogt, D., Mayes, J., Westveer, M.K., Carey, W. Hepatology (1997) [Pubmed]
  25. Fully synthetic carbohydrate-based vaccines in biochemically relapsed prostate cancer: clinical trial results with alpha-N-acetylgalactosamine-O-serine/threonine conjugate vaccine. Slovin, S.F., Ragupathi, G., Musselli, C., Olkiewicz, K., Verbel, D., Kuduk, S.D., Schwarz, J.B., Sames, D., Danishefsky, S., Livingston, P.O., Scher, H.I. J. Clin. Oncol. (2003) [Pubmed]
  26. Ineffectiveness of ascorbic acid therapy in nephropathic cystinosis. Schneider, J.A., Schlesselman, J.J., Mendoza, S.A., Orloff, S., Thoene, J.G., Kroll, W.A., Godfrey, A.D., Schulman, J.D. N. Engl. J. Med. (1979) [Pubmed]
  27. Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates. Schmidt, M., Carbonaro, D.A., Speckmann, C., Wissler, M., Bohnsack, J., Elder, M., Aronow, B.J., Nolta, J.A., Kohn, D.B., von Kalle, C. Nat. Med. (2003) [Pubmed]
  28. Clonal T cell expansion induced by interleukin 2 therapy in blood and tumors. Kumar, A., Farace, F., Gaudin, C., Triebel, F. J. Clin. Invest. (1996) [Pubmed]
  29. Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial. Fisher, B., Dignam, J., Bryant, J., Wolmark, N. J. Natl. Cancer Inst. (2001) [Pubmed]
  30. Dose-intense taxol: high response rate in patients with platinum-resistant recurrent ovarian cancer. Kohn, E.C., Sarosy, G., Bicher, A., Link, C., Christian, M., Steinberg, S.M., Rothenberg, M., Adamo, D.O., Davis, P., Ognibene, F.P. J. Natl. Cancer Inst. (1994) [Pubmed]
  31. Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-versus-host disease. Chao, N.J., Schmidt, G.M., Niland, J.C., Amylon, M.D., Dagis, A.C., Long, G.D., Nademanee, A.P., Negrin, R.S., O'Donnell, M.R., Parker, P.M. N. Engl. J. Med. (1993) [Pubmed]
  32. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. Riggs, B.L., Hodgson, S.F., O'Fallon, W.M., Chao, E.Y., Wahner, H.W., Muhs, J.M., Cedel, S.L., Melton, L.J. N. Engl. J. Med. (1990) [Pubmed]
  33. Prednisone and cyclosporine in the treatment of severe Graves' ophthalmopathy. Prummel, M.F., Mourits, M.P., Berghout, A., Krenning, E.P., van der Gaag, R., Koornneef, L., Wiersinga, W.M. N. Engl. J. Med. (1989) [Pubmed]
  34. Randomized clinical trial of atenolol in patients with alcohol withdrawal. Kraus, M.L., Gottlieb, L.D., Horwitz, R.I., Anscher, M. N. Engl. J. Med. (1985) [Pubmed]
  35. A comparison of androgens for anemia in patients on hemodialysis. Neff, M.S., Goldberg, J., Slifkin, R.F., Eiser, A.R., Calamia, V., Kaplan, M., Baez, A., Gupta, S., Mattoo, N. N. Engl. J. Med. (1981) [Pubmed]
  36. TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Tantisira, K.G., Hwang, E.S., Raby, B.A., Silverman, E.S., Lake, S.L., Richter, B.G., Peng, S.L., Drazen, J.M., Glimcher, L.H., Weiss, S.T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  37. Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia. Morris, J.C., Janik, J.E., White, J.D., Fleisher, T.A., Brown, M., Tsudo, M., Goldman, C.K., Bryant, B., Petrus, M., Top, L., Lee, C.C., Gao, W., Waldmann, T.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  38. Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPalpha expression. Zheng, R., Friedman, A.D., Levis, M., Li, L., Weir, E.G., Small, D. Blood (2004) [Pubmed]
  39. Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study. Leith, C.P., Kopecky, K.J., Chen, I.M., Eijdems, L., Slovak, M.L., McConnell, T.S., Head, D.R., Weick, J., Grever, M.R., Appelbaum, F.R., Willman, C.L. Blood (1999) [Pubmed]
  40. Randomized placebo-controlled clinical trial of high-dose interleukin-2 in combination with a soluble p75 tumor necrosis factor receptor immunoglobulin G chimera in patients with advanced melanoma and renal cell carcinoma. Du Bois, J.S., Trehu, E.G., Mier, J.W., Shapiro, L., Epstein, M., Klempner, M., Dinarello, C., Kappler, K., Ronayne, L., Rand, W., Atkins, M.B. J. Clin. Oncol. (1997) [Pubmed]
  41. Cost-effective priorities for cancer prevention. Weinstein, M.C. Science (1983) [Pubmed]
  42. Determinants of the pressor effect of phenylpropanolamine in healthy subjects. Blackburn, G.L., Morgan, J.P., Lavin, P.T., Noble, R., Funderburk, F.R., Istfan, N. JAMA (1989) [Pubmed]
  43. Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1. Mandelbrot, L., Landreau-Mascaro, A., Rekacewicz, C., Berrebi, A., Bénifla, J.L., Burgard, M., Lachassine, E., Barret, B., Chaix, M.L., Bongain, A., Ciraru-Vigneron, N., Crenn-Hébert, C., Delfraissy, J.F., Rouzioux, C., Mayaux, M.J., Blanche, S. JAMA (2001) [Pubmed]
  44. Glucocorticoid treatment does not improve neurological recovery following cardiac arrest. Brain Resuscitation Clinical Trial I Study Group. Jastremski, M., Sutton-Tyrrell, K., Vaagenes, P., Abramson, N., Heiselman, D., Safar, P. JAMA (1989) [Pubmed]
  45. Digitized mammography: a clinical trial of postmenopausal women randomly assigned to receive raloxifene, estrogen, or placebo. Freedman, M., San Martin, J., O'Gorman, J., Eckert, S., Lippman, M.E., Lo, S.C., Walls, E.L., Zeng, J. J. Natl. Cancer Inst. (2001) [Pubmed]
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