Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-0D66IR trimethyl-(4-oxobutyl)azanium

Synonyms: AG-K-78159, CHEBI:18020, HMDB01345, AC1Q6QJW, CTK5C1452, ...

Vaz, F.M. et al.

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Disease relevance of gamma-Trimethylaminobutyraldehyde

Expression of the coding sequence in Escherichia coli confirmed that the cDNA encodes gamma-trimethylaminobutyraldehyde dehydrogenase [1].

High impact information on gamma-Trimethylaminobutyraldehyde

The penultimate step in carnitine biosynthesis is mediated by gamma-trimethylaminobutyraldehyde dehydrogenase (EC 1.2.1.47), a cytosolic NAD(+)-dependent aldehyde dehydrogenase that converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine [1].
Furthermore, comparison of the enzymatic characteristics of the heterologously expressed human and rat dehydrogenases with those of purified rat liver trimethylaminobutyraldehyde dehydrogenase revealed that the three enzymes have highly similar substrate specificities [1].

Gene context of gamma-Trimethylaminobutyraldehyde

When aldehyde dehydrogenase 9 was expressed in E. coli, it exhibited high trimethylaminobutyraldehyde dehydrogenase activity [1].

References

Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis. Vaz, F.M., Fouchier, S.W., Ofman, R., Sommer, M., Wanders, R.J. J. Biol. Chem. (2000) [Pubmed]

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