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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Substrate Specificity

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Gene context of Substrate Specificity


Analytical, diagnostic and therapeutic context of Substrate Specificity


  1. Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance. Darby, G., Field, H.J., Salisbury, S.A. Nature (1981) [Pubmed]
  2. A specific, highly active malate dehydrogenase by redesign of a lactate dehydrogenase framework. Wilks, H.M., Hart, K.W., Feeney, R., Dunn, C.R., Muirhead, H., Chia, W.N., Barstow, D.A., Atkinson, T., Clarke, A.R., Holbrook, J.J. Science (1988) [Pubmed]
  3. Two distinct but interchangeable mechanisms for flipping of lipid-linked oligosaccharides. Alaimo, C., Catrein, I., Morf, L., Marolda, C.L., Callewaert, N., Valvano, M.A., Feldman, M.F., Aebi, M. EMBO J. (2006) [Pubmed]
  4. An engineered retroviral proteinase from myeloblastosis associated virus acquires pH dependence and substrate specificity of the HIV-1 proteinase. Konvalinka, J., Horejsí, M., Andreánsky, M., Novek, P., Pichová, I., Bláha, I., Fábry, M., Sedlácek, J., Foundling, S., Strop, P. EMBO J. (1992) [Pubmed]
  5. The tra-3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family. Barnes, T.M., Hodgkin, J. EMBO J. (1996) [Pubmed]
  6. Enzyme electrode based on oxalate oxidase immobilized in gelatin for specific determination of oxalate. Dinckaya, E., Telefoncu, A. Indian J. Biochem. Biophys. (1993) [Pubmed]
  7. Function of cGMP-dependent protein kinases as revealed by gene deletion. Hofmann, F., Feil, R., Kleppisch, T., Schlossmann, J. Physiol. Rev. (2006) [Pubmed]
  8. Structural insight into the mechanism of double-stranded RNA processing by ribonuclease III. Gan, J., Tropea, J.E., Austin, B.P., Court, D.L., Waugh, D.S., Ji, X. Cell (2006) [Pubmed]
  9. Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs. Lochhead, P.A., Sibbet, G., Morrice, N., Cleghon, V. Cell (2005) [Pubmed]
  10. Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. Dajani, R., Fraser, E., Roe, S.M., Young, N., Good, V., Dale, T.C., Pearl, L.H. Cell (2001) [Pubmed]
  11. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Niederreither, K., Subbarayan, V., Dollé, P., Chambon, P. Nat. Genet. (1999) [Pubmed]
  12. Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG. Wenig, K., Chatwell, L., von Pawel-Rammingen, U., Björck, L., Huber, R., Sondermann, P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  13. Thioredoxin, glutaredoxin, and thioredoxin reductase from cultured HeLa cells. Tsang, M.L., Weatherbee, J.A. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  14. New enzymes for old: redesigning the coenzyme and substrate specificities of glutathione reductase. Perham, R.N., Scrutton, N.S., Berry, A. Bioessays (1991) [Pubmed]
  15. Substrate specificity of the hepatitis C virus serine protease NS3. Urbani, A., Bianchi, E., Narjes, F., Tramontano, A., De Francesco, R., Steinkühler, C., Pessi, A. J. Biol. Chem. (1997) [Pubmed]
  16. O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. Lubas, W.A., Frank, D.W., Krause, M., Hanover, J.A. J. Biol. Chem. (1997) [Pubmed]
  17. Identification and characterization of the vesicular GABA transporter. McIntire, S.L., Reimer, R.J., Schuske, K., Edwards, R.H., Jorgensen, E.M. Nature (1997) [Pubmed]
  18. A brain-specific activator of cyclin-dependent kinase 5. Lew, J., Huang, Q.Q., Qi, Z., Winkfein, R.J., Aebersold, R., Hunt, T., Wang, J.H. Nature (1994) [Pubmed]
  19. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Kuida, K., Zheng, T.S., Na, S., Kuan, C., Yang, D., Karasuyama, H., Rakic, P., Flavell, R.A. Nature (1996) [Pubmed]
  20. Toward a model for the interaction between elongation factor Tu and the ribosome. Weijland, A., Parmeggiani, A. Science (1993) [Pubmed]
  21. Vascular endothelial cells synthesize nitric oxide from L-arginine. Palmer, R.M., Ashton, D.S., Moncada, S. Nature (1988) [Pubmed]
  22. Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin. Ferreira, P.A., Nakayama, T.A., Pak, W.L., Travis, G.H. Nature (1996) [Pubmed]
  23. Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells. Wang, G.Q., Wieckowski, E., Goldstein, L.A., Gastman, B.R., Rabinovitz, A., Gambotto, A., Li, S., Fang, B., Yin, X.M., Rabinowich, H. J. Exp. Med. (2001) [Pubmed]
  24. Independence of herpesvirus-induced T cell lymphoma from viral cyclin D homologue. Ensser, A., Glykofrydes, D., Niphuis, H., Kuhn, E.M., Rosenwirth, B., Heeney, J.L., Niedobitek, G., Müller-Fleckenstein, I., Fleckenstein, B. J. Exp. Med. (2001) [Pubmed]
  25. L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia. Roe, C.R., Millington, D.S., Maltby, D.A., Bohan, T.P., Hoppel, C.L. J. Clin. Invest. (1984) [Pubmed]
  26. Substrate specificity and affinity of a protein modulated by bound water molecules. Quiocho, F.A., Wilson, D.K., Vyas, N.K. Nature (1989) [Pubmed]
  27. Reconstruction of an enzyme by domain substitution effectively switches substrate specificity. Houghton, J.E., O'Donovan, G.A., Wild, J.R. Nature (1989) [Pubmed]
  28. Similarity of the nucleotide sequences of rat alpha-lactalbumin and chicken lysozyme genes. Qasba, P.K., Safaya, S.K. Nature (1984) [Pubmed]
  29. Amino acid sequence of rat submaxillary tonin reveals similarities to serine proteases. Lazure, C., Leduc, R., Seidah, N.G., Thibault, G., Genest, J., Chrétien, M. Nature (1984) [Pubmed]
  30. Angiotensin II-forming activity in a reconstructed ancestral chymase. Chandrasekharan, U.M., Sanker, S., Glynias, M.J., Karnik, S.S., Husain, A. Science (1996) [Pubmed]
  31. Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. Harrington, J.J., Lieber, M.R. Genes Dev. (1994) [Pubmed]
  32. Structure and regulation of the CDK5-p25(nck5a) complex. Tarricone, C., Dhavan, R., Peng, J., Areces, L.B., Tsai, L.H., Musacchio, A. Mol. Cell (2001) [Pubmed]
  33. H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat. Anderson, C.M., Grenade, D.S., Boll, M., Foltz, M., Wake, K.A., Kennedy, D.J., Munck, L.K., Miyauchi, S., Taylor, P.M., Campbell, F.C., Munck, B.G., Daniel, H., Ganapathy, V., Thwaites, D.T. Gastroenterology (2004) [Pubmed]
  34. Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH. Rossignol, M., Kolb-Cheynel, I., Egly, J.M. EMBO J. (1997) [Pubmed]
  35. An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity. Goi, T., Shipitsin, M., Lu, Z., Foster, D.A., Klinz, S.G., Feig, L.A. EMBO J. (2000) [Pubmed]
  36. Heparin-enhanced plasma phospholipase A2 activity and prostacyclin synthesis in patients undergoing cardiac surgery. Nakamura, H., Kim, D.K., Philbin, D.M., Peterson, M.B., Debros, F., Koski, G., Bonventre, J.V. J. Clin. Invest. (1995) [Pubmed]
  37. Isolation and properties of a nitrile hydratase from the soil fungus Myrothecium verrucaria that is highly specific for the fertilizer cyanamide and cloning of its gene. Maier-Greiner, U.H., Obermaier-Skrobranek, B.M., Estermaier, L.M., Kammerloher, W., Freund, C., Wülfing, C., Burkert, U.I., Matern, D.H., Breuer, M., Eulitz, M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  38. Directed evolution of an aspartate aminotransferase with new substrate specificities. Yano, T., Oue, S., Kagamiyama, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  39. Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase. Patel, D., Butler, J.S. Mol. Cell. Biol. (1992) [Pubmed]
  40. Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine. Woodman, P.W., Sarrif, A.M., Heidelberger, C. Cancer Res. (1980) [Pubmed]
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