Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL222744 2-amino-9-(2- hydroxyethoxymethyl)-3,7...

Synonyms: CTK8D9681, AR-1H5309, AC1L32XL, AC1Q6L23, 85179-66-4, ...

de Miranda, P. et al., Krenitsky, T.A. et al.

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High impact information on 8-Hydroxyacyclovir

It was also oxidized by aldehyde oxidase (EC 1.2.3.1) largely to 8-hydroxy-6- deoxyacyclovir [2-amino-8-hydroxy-9-[(2-hydroxyethoxy)methyl]-9H-purine] and then to 8- hydroxyacyclovir [2-amino-6,8-dihydroxy-9[(2-hydroxyethoxy)methyl]-9H-purine] [1].
The major urinary metabolites of [8-14C]valaciclovir, administered orally (10 and 25 mg/kg) or intravenously (10 mg/kg) to male monkeys, were acyclovir (46%-59% of urinary radioactivity), 8-hydroxyacyclovir (25%-30%), and 9-(carboxymethoxymethyl)guanine (CMMG) (11%-12%) [2].

References

6-Deoxyacyclovir: a xanthine oxidase-activated prodrug of acyclovir. Krenitsky, T.A., Hall, W.W., de Miranda, P., Beauchamp, L.M., Schaeffer, H.J., Whiteman, P.D. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
Metabolic fate and pharmacokinetics of the acyclovir prodrug valaciclovir in cynomolgus monkeys. de Miranda, P., Burnette, T.C. Drug Metab. Dispos. (1994) [Pubmed]

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