The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEMBL222744     2-amino-9-(2- hydroxyethoxymethyl)-3,7...

Synonyms: CTK8D9681, AR-1H5309, AC1L32XL, AC1Q6L23, 85179-66-4, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on 8-Hydroxyacyclovir

  • It was also oxidized by aldehyde oxidase (EC largely to 8-hydroxy-6- deoxyacyclovir [2-amino-8-hydroxy-9-[(2-hydroxyethoxy)methyl]-9H-purine] and then to 8- hydroxyacyclovir [2-amino-6,8-dihydroxy-9[(2-hydroxyethoxy)methyl]-9H-purine] [1].
  • The major urinary metabolites of [8-14C]valaciclovir, administered orally (10 and 25 mg/kg) or intravenously (10 mg/kg) to male monkeys, were acyclovir (46%-59% of urinary radioactivity), 8-hydroxyacyclovir (25%-30%), and 9-(carboxymethoxymethyl)guanine (CMMG) (11%-12%) [2].


  1. 6-Deoxyacyclovir: a xanthine oxidase-activated prodrug of acyclovir. Krenitsky, T.A., Hall, W.W., de Miranda, P., Beauchamp, L.M., Schaeffer, H.J., Whiteman, P.D. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  2. Metabolic fate and pharmacokinetics of the acyclovir prodrug valaciclovir in cynomolgus monkeys. de Miranda, P., Burnette, T.C. Drug Metab. Dispos. (1994) [Pubmed]
WikiGenes - Universities