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Chemical Compound Review:

Magnoshinin (1R,2S)-5,7,8-trimethoxy-2,3- dimethyl-1-(2...

Synonyms: AC1L3732, 86702-02-5

Kobayashi, S. et al., Kimura, I. et al., Kimura, M. et al., Kimura, M. et al.

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Disease relevance of Magnoshinin

In contrast, intraperitoneal magnoshinin inhibited granuloma formation 2.5-fold more strongly than angiogenesis [1].

High impact information on Magnoshinin

Anti-proliferative effects of magnoshinin and magnosalin derived from "Shin-i" (Flos magnoliae) were investigated using subcultured endothelial cells (EC) of rat aorta [2].
The inhibitory effects of magnoshinin were 2-fold greater at 10 micrograms/ml than that of magnosalin on the increase in cell number when EC were stimulated by 5% fetal bovine serum [2].
Their IC50 values (95% confidence limits) were 1.22 (1.01-1.47) for MSA and 0.74 microM (0.24-2.31) for MSI against a submaximal concentration (69 pM) of IL-1 alpha-stimulated tube formation [3].
Magnosalin (MSA) and magnoshinin (MSI), neolignans isolated from magnolia, have a crucial role in the anti-angiogenic effect of magnolia (Kimura et al., Int. Arch. Allergy Appl. Immunol., 93, 365 (1990); Phytother. Res., 6, 209 (1992)) [3].
Inhibitory effects of magnosalin and magnoshinin, compounds from the crude drug "Shin-i" (Flos magnoliae), on angiogenesis and pouch granuloma formation in mice induced by an adjuvant containing croton oil were investigated [4].

Chemical compound and disease context of Magnoshinin

These results show that the anti-chronic inflammatory effect of 'Shin-i' was caused by selective inhibition of angiogenesis by magnosalin and of granuloma formation by magnoshinin [1].

References

Selective inhibition by magnosalin and magnoshinin, compounds from 'shin-i' (Flos magnoliae), of adjuvant-induced angiogenesis and granuloma formation in the mouse pouch. Kimura, M., Kobayashi, S., Luo, B., Kimura, I. Int. Arch. Allergy Appl. Immunol. (1990) [Pubmed]
Inhibitory effects of magnoshinin and magnosalin, compounds from "Shin-i" (Flos magnoliae), on the competence and progression phases in proliferation of subcultured rat aortic endothelial cells. Kimura, I., Nagaura, T., Kobayashi, S., Kimura, M. Jpn. J. Pharmacol. (1992) [Pubmed]
Inhibitory effect of magnosalin derived from Flos magnoliae on tube formation of rat vascular endothelial cells during the angiogenic process. Kobayashi, S., Kimura, I., Kimura, M. Biol. Pharm. Bull. (1996) [Pubmed]
Selective inhibition by magnosalin and magnoshinin, compounds from "Shin-i" (Flos magnoliae), of adjuvant-induced angiogenesis and granuloma formation in the mouse pouch. Kimura, M., Kobayashi, S., Luo, B., Kimura, I. Agents Actions Suppl. (1991) [Pubmed]

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