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Chemical Compound Review

Heterotropan     1-[2,3-dimethyl-4-(2,4,5...

Synonyms: AGN-PC-00O7D1, KST-1B8383, MEGxp0_001334, AR-1B3475, AC1L2Q4K, ...
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Disease relevance of Bisasaricin

  • Inhibitory effects of anti-rheumatic drugs containing magnosalin, a compound from 'Shin-i' (Flos magnoliae), on the proliferation of synovial cells in rheumatoid arthritis models [1].
  • The effects of magnosalin for FBS-induced thymidine incorporation into the cells of the CIA mice and the RA patients were significantly greater than those in the corresponding control mice and osteoarthritis patients [1].
  • Magnosalin inhibited angiogenesis 2.4-fold (intra-pouch) and 9.7-fold (intraperitoneal) more strongly than granuloma formation [2].

High impact information on Bisasaricin


Chemical compound and disease context of Bisasaricin


Analytical, diagnostic and therapeutic context of Bisasaricin

  • This study was undertaken to examine the effects of magnosalin, a compound isolated from 'Shin-i' (Flos magnoliae) on proliferation of synovial cells isolated from MRL/1pr and collagen-induced arthritis (CIA) mice, and rheumatoid arthritis (RA) patients [1].
  • Synthesis of a magnosalin derivative, 4-(3,4,5-trimethoxyphenyl)-6-(2,4,5-trimethoxyphenyl)-2-diethylaminopyrimidine, and the anti-angiogenic and anti-rheumatic effect on mice by oral administration [3].


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