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Chemical Compound Review

Demoxepam     10-chloro-3-hydroxy-2-phenyl- 3,6...

Synonyms: Demossepam, Demoxepamum, Bio-0752, CHEMBL1597677, ANW-57915, ...
 
 
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Disease relevance of NSC 46077

  • The kinetics of chloridazepoxide were within the predicted range for patients with liver disease, but the elimination half-lives of desmethylchlordiazepoxide and demoxepam were greatly prolonged at 346 hours and 150 hours, respectively [1].
 

High impact information on NSC 46077

 

Associations of NSC 46077 with other chemical compounds

 

Analytical, diagnostic and therapeutic context of NSC 46077

  • This reaction serves as a sensitive and selective means of detection of low levels of demoxepam in e.g., serum after separation by means of reversed-phase high-performance liquid chromatography [6].
  • 1 A high pressure liquid chromatographic (HPLC) assay has been developed for the measurement of chlordiazepoxide and its metabolites, N-desmethylchlordiazepoxide and demoxepam in microgram concentrations in human plasma [7].

References

  1. Chlordiazepoxide metabolite accumulation in liver disease. Barton, K., Auld, P.W., Scott, M.G., Nicholls, D.P. Medical toxicology and adverse drug experience. (1989) [Pubmed]
  2. Quantitative determination of chlordiazepoxide and its metabolites in serum by fluorescence TLC--densitometry. Sun, S.R. Journal of pharmaceutical sciences. (1978) [Pubmed]
  3. Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines I: chlordiazepoxide and demoxepam. Han, W.W., Yakatan, G.J., Maness, D.D. Journal of pharmaceutical sciences. (1976) [Pubmed]
  4. Use of direct-probe mass spectrometry as a toxicology confirmation method for demoxepam in urine following high-performance liquid chromatography. Essien, H., Lai, S.J., Binder, S.R., King, D.L. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]
  5. Determination of chlordiazepoxide, diazepam, and their major metabolites in blood or plasma by spectrophotodensitometry. Stronjny, N., Bratin, K., Brooks, M.A., de Silva, J.A. J. Chromatogr. (1977) [Pubmed]
  6. Liquid chromatography of demoxepam and phenothiazines using a post-column photochemical reactor and fluorescence detection. Brinkman, U.A., Welling, P.L., de Vries, G., Scholten, A.H., Frei, R.W. J. Chromatogr. (1981) [Pubmed]
  7. The application of HPLC to the determination of some 1,4 benzodiazepines and their metabolites in plasma. Skellern, G.G., Meier, J., Knight, B.I., Whiting, B. British journal of clinical pharmacology. (1978) [Pubmed]
 
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