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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Toxicology

 
 
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Disease relevance of Toxicology

  • Human pharmacology and toxicology of succinylated Acinetobacter glutaminase-asparaginase [1].
  • This review describes preclinical toxicology findings associated with simvastatin administration in animals and provides the rationale for our conclusion that these changes are not indicative of potential human toxicity [2].
  • CONCLUSIONS: On the basis of self-report and urine toxicology, overall maternal hard drug use and cocaine use in the WITS cohort were associated with maternal HIV culture positivity at delivery, and maternal hard drug use was associated with perinatal transmission [3].
  • Histamine food poisoning: toxicology and clinical aspects [4].
  • This paper describes a preclinical toxicology study designed to investigate the biological efficacy and safety profile of second-generation adenovirus for CFTR gene transfer into the baboon lung [5].
 

Psychiatry related information on Toxicology

 

High impact information on Toxicology

 

Chemical compound and disease context of Toxicology

 

Biological context of Toxicology

 

Anatomical context of Toxicology

 

Associations of Toxicology with chemical compounds

 

Gene context of Toxicology

  • A role for P-glycoprotein in environmental toxicology [35].
  • Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds [36].
  • These findings suggest a role for polymorphic CYP2D6 in the pharmacology and toxicology of harmine and harmaline [37].
  • In this review, we provide a concise state-of-the-art description of the role of COX in pharmacology and toxicology of skin including its involvement in normal physiology, cutaneous inflammation, nociception, wound healing, and tumorigenesis [38].
  • We investigated AHRR structure, function, evolution, and regulation in zebrafish, a powerful model in developmental biology and toxicology [39].
 

Analytical, diagnostic and therapeutic context of Toxicology

References

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  2. Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme A reductase inhibitors. Gerson, R.J., MacDonald, J.S., Alberts, A.W., Kornbrust, D.J., Majka, J.A., Stubbs, R.J., Bokelman, D.L. Am. J. Med. (1989) [Pubmed]
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  5. Transfer of the CFTR gene to the lung of nonhuman primates with E1-deleted, E2a-defective recombinant adenoviruses: a preclinical toxicology study. Goldman, M.J., Litzky, L.A., Engelhardt, J.F., Wilson, J.M. Hum. Gene Ther. (1995) [Pubmed]
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  20. Oxidative stress, toxicology, and pharmacology of CYP2E1. Caro, A.A., Cederbaum, A.I. Annu. Rev. Pharmacol. Toxicol. (2004) [Pubmed]
  21. Review of 2,4-dichlorophenoxyacetic acid (2,4-D) epidemiology and toxicology. Garabrant, D.H., Philbert, M.A. Crit. Rev. Toxicol. (2002) [Pubmed]
  22. Preclinical overview of nabumetone. Pharmacology, bioavailability, metabolism, and toxicology. Mangan, F.R., Flack, J.D., Jackson, D. Am. J. Med. (1987) [Pubmed]
  23. Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA), a novel endogenous marker for cell proliferation. Dietrich, D.R. Crit. Rev. Toxicol. (1993) [Pubmed]
  24. Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Trapani, G., Altomare, C., Liso, G., Sanna, E., Biggio, G. Current medicinal chemistry. (2000) [Pubmed]
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  28. Cerebrospinal fluid pharmacokinetics and toxicology of intraventricular and intrathecal arabinosyl-5-azacytosine (fazarabine, NSC 281272) in the nonhuman primate. Heideman, R.L., McCully, C., Balis, F.M., Poplack, D.G. Investigational new drugs. (1993) [Pubmed]
  29. Influence of prenatal cocaine exposure on full-term infant neurobehavioral functioning. Morrow, C.E., Bandstra, E.S., Anthony, J.C., Ofir, A.Y., Xue, L., Reyes, M.L. Neurotoxicology and teratology. (2001) [Pubmed]
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  39. Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo. Evans, B.R., Karchner, S.I., Franks, D.G., Hahn, M.E. Arch. Biochem. Biophys. (2005) [Pubmed]
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