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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Toxicology

  • Human pharmacology and toxicology of succinylated Acinetobacter glutaminase-asparaginase [1].
  • This review describes preclinical toxicology findings associated with simvastatin administration in animals and provides the rationale for our conclusion that these changes are not indicative of potential human toxicity [2].
  • CONCLUSIONS: On the basis of self-report and urine toxicology, overall maternal hard drug use and cocaine use in the WITS cohort were associated with maternal HIV culture positivity at delivery, and maternal hard drug use was associated with perinatal transmission [3].
  • Histamine food poisoning: toxicology and clinical aspects [4].
  • This paper describes a preclinical toxicology study designed to investigate the biological efficacy and safety profile of second-generation adenovirus for CFTR gene transfer into the baboon lung [5].

Psychiatry related information on Toxicology


High impact information on Toxicology


Chemical compound and disease context of Toxicology


Biological context of Toxicology


Anatomical context of Toxicology


Associations of Toxicology with chemical compounds


Gene context of Toxicology

  • A role for P-glycoprotein in environmental toxicology [35].
  • Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds [36].
  • These findings suggest a role for polymorphic CYP2D6 in the pharmacology and toxicology of harmine and harmaline [37].
  • In this review, we provide a concise state-of-the-art description of the role of COX in pharmacology and toxicology of skin including its involvement in normal physiology, cutaneous inflammation, nociception, wound healing, and tumorigenesis [38].
  • We investigated AHRR structure, function, evolution, and regulation in zebrafish, a powerful model in developmental biology and toxicology [39].

Analytical, diagnostic and therapeutic context of Toxicology


  1. Human pharmacology and toxicology of succinylated Acinetobacter glutaminase-asparaginase. Holcenberg, J.S., Borella, L.D., Camitta, B.M., Ring, B.J. Cancer Res. (1979) [Pubmed]
  2. Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme A reductase inhibitors. Gerson, R.J., MacDonald, J.S., Alberts, A.W., Kornbrust, D.J., Majka, J.A., Stubbs, R.J., Bokelman, D.L. Am. J. Med. (1989) [Pubmed]
  3. Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission. Rodriguez, E.M., Mofenson, L.M., Chang, B.H., Rich, K.C., Fowler, M.G., Smeriglio, V., Landesman, S., Fox, H.E., Diaz, C., Green, K., Hanson, I.C. AIDS (1996) [Pubmed]
  4. Histamine food poisoning: toxicology and clinical aspects. Taylor, S.L. Crit. Rev. Toxicol. (1986) [Pubmed]
  5. Transfer of the CFTR gene to the lung of nonhuman primates with E1-deleted, E2a-defective recombinant adenoviruses: a preclinical toxicology study. Goldman, M.J., Litzky, L.A., Engelhardt, J.F., Wilson, J.M. Hum. Gene Ther. (1995) [Pubmed]
  6. A randomized trial of buprenorphine maintenance for heroin dependence in a primary care clinic for substance users versus a methadone clinic. O'Connor, P.G., Oliveto, A.H., Shi, J.M., Triffleman, E.G., Carroll, K.M., Kosten, T.R., Rounsaville, B.J., Pakes, J.A., Schottenfeld, R.S. Am. J. Med. (1998) [Pubmed]
  7. Community-wide estimation of illicit drug use in delivering women: prevalence, demographics, and associated risk factors. Vaughn, A.J., Carzoli, R.P., Sanchez-Ramos, L., Murphy, S., Khan, N., Chiu, T. Obstetrics and gynecology. (1993) [Pubmed]
  8. Applications of AmpliChip CYP450. Jain, K.K. Mol. Diagn. (2005) [Pubmed]
  9. Monitoring of verapamil enantiomers concentration in overdose. Wilimowska, J., Piekoszewski, W., Krzyanowska-Kierepka, E., Florek, E. Clinical toxicology (Philadelphia, Pa.) (2006) [Pubmed]
  10. Mammalian ABC transporters in health and disease. Borst, P., Elferink, R.O. Annu. Rev. Biochem. (2002) [Pubmed]
  11. Toxicology. Panel backs EPA dioxin assessment. Kaiser, J. Science (2000) [Pubmed]
  12. Toxicology. Arsenic researchers face isotope shortage. Kaiser, J. Science (2000) [Pubmed]
  13. Toxicology. Mercury report backs strict rules. Kaiser, J. Science (2000) [Pubmed]
  14. Pharmacology of cyclosporine (sandimmune). VII. Pathophysiology and toxicology of cyclosporine in humans and animals. Mason, J. Pharmacol. Rev. (1990) [Pubmed]
  15. Treatment and prophylaxis of disseminated infection due to Candida albicans in mice with liposome-encapsulated amphotericin B. Lopez-Berestein, G., Mehta, R., Hopfer, R.L., Mills, K., Kasi, L., Mehta, K., Fainstein, V., Luna, M., Hersh, E.M., Juliano, R. J. Infect. Dis. (1983) [Pubmed]
  16. Preclinical and toxicology studies of 1263W94, a potent and selective inhibitor of human cytomegalovirus replication. Koszalka, G.W., Johnson, N.W., Good, S.S., Boyd, L., Chamberlain, S.C., Townsend, L.B., Drach, J.C., Biron, K.K. Antimicrob. Agents Chemother. (2002) [Pubmed]
  17. Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Mendel, D.B., Tai, C.Y., Escarpe, P.A., Li, W., Sidwell, R.W., Huffman, J.H., Sweet, C., Jakeman, K.J., Merson, J., Lacy, S.A., Lew, W., Williams, M.A., Zhang, L., Chen, M.S., Bischofberger, N., Kim, C.U. Antimicrob. Agents Chemother. (1998) [Pubmed]
  18. Low dose methotrexate in inflammatory bowel disease: current status and future directions. Schröder, O., Stein, J. Am. J. Gastroenterol. (2003) [Pubmed]
  19. Bromperidol, a new butyrophenone neuroleptic: a review. Dubinsky, B., McGuire, J.L., Niemegeers, C.J., Janssen, P.A., Weintraub, H.S., McKenzie, B.E. Psychopharmacology (Berl.) (1982) [Pubmed]
  20. Oxidative stress, toxicology, and pharmacology of CYP2E1. Caro, A.A., Cederbaum, A.I. Annu. Rev. Pharmacol. Toxicol. (2004) [Pubmed]
  21. Review of 2,4-dichlorophenoxyacetic acid (2,4-D) epidemiology and toxicology. Garabrant, D.H., Philbert, M.A. Crit. Rev. Toxicol. (2002) [Pubmed]
  22. Preclinical overview of nabumetone. Pharmacology, bioavailability, metabolism, and toxicology. Mangan, F.R., Flack, J.D., Jackson, D. Am. J. Med. (1987) [Pubmed]
  23. Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA), a novel endogenous marker for cell proliferation. Dietrich, D.R. Crit. Rev. Toxicol. (1993) [Pubmed]
  24. Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Trapani, G., Altomare, C., Liso, G., Sanna, E., Biggio, G. Current medicinal chemistry. (2000) [Pubmed]
  25. Ciprofloxacin: toxicologic evaluation of additional safety data. Schluter, G. Am. J. Med. (1989) [Pubmed]
  26. Di(2-ethylhexyl)phthalate: lack of initiating activity in the liver of female F-344 rats. Garvey, L.K., Swenberg, J.A., Hamm, T.E., Popp, J.A. Carcinogenesis (1987) [Pubmed]
  27. Application of surface-enhanced laser desorption/ionization technology to the detection and identification of urinary parvalbumin-alpha: a biomarker of compound-induced skeletal muscle toxicity in the rat. Dare, T.O., Davies, H.A., Turton, J.A., Lomas, L., Williams, T.C., York, M.J. Electrophoresis (2002) [Pubmed]
  28. Cerebrospinal fluid pharmacokinetics and toxicology of intraventricular and intrathecal arabinosyl-5-azacytosine (fazarabine, NSC 281272) in the nonhuman primate. Heideman, R.L., McCully, C., Balis, F.M., Poplack, D.G. Investigational new drugs. (1993) [Pubmed]
  29. Influence of prenatal cocaine exposure on full-term infant neurobehavioral functioning. Morrow, C.E., Bandstra, E.S., Anthony, J.C., Ofir, A.Y., Xue, L., Reyes, M.L. Neurotoxicology and teratology. (2001) [Pubmed]
  30. Retinoic acid: biochemistry, pharmacology, toxicology, and therapeutic use. Chytil, F. Pharmacol. Rev. (1984) [Pubmed]
  31. Solvent toxicology: recent advances in the toxicology of benzene, the glycol ethers, and carbon tetrachloride. Kalf, G.F., Post, G.B., Snyder, R. Annu. Rev. Pharmacol. Toxicol. (1987) [Pubmed]
  32. The mechanistic toxicology of formaldehyde and its implications for quantitative risk estimation. Starr, T.B., Gibson, J.E. Annu. Rev. Pharmacol. Toxicol. (1985) [Pubmed]
  33. Ethnopharmacology of Mexican asteraceae (Compositae). Heinrich, M., Robles, M., West, J.E., Ortiz de Montellano, B.R., Rodriguez, E. Annu. Rev. Pharmacol. Toxicol. (1998) [Pubmed]
  34. Pharmacology and toxicology of lithium. Schou, M. Annu. Rev. Pharmacol. Toxicol. (1976) [Pubmed]
  35. A role for P-glycoprotein in environmental toxicology. Abu-Qare, A.W., Elmasry, E., Abou-Donia, M.B. Journal of toxicology and environmental health. Part B, Critical reviews. (2003) [Pubmed]
  36. A cytochrome P4501B gene from a fish, Pleuronectes platessa. Leaver, M.J., George, S.G. Gene (2000) [Pubmed]
  37. Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine. Yu, A.M., Idle, J.R., Krausz, K.W., Küpfer, A., Gonzalez, F.J. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  38. Cyclooxygenases in the skin: pharmacological and toxicological implications. Lee, J.L., Mukhtar, H., Bickers, D.R., Kopelovich, L., Athar, M. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  39. Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo. Evans, B.R., Karchner, S.I., Franks, D.G., Hahn, M.E. Arch. Biochem. Biophys. (2005) [Pubmed]
  40. Cytotoxicity and cell-proliferation induced by the nephrocarcinogen hydroquinone and its nephrotoxic metabolite 2,3,5-(tris-glutathion-S-yl)hydroquinone. Peters, M.M., Jones, T.W., Monks, T.J., Lau, S.S. Carcinogenesis (1997) [Pubmed]
  41. Propagation and immortalization of human lens epithelial cells in culture. Andley, U.P., Rhim, J.S., Chylack, L.T., Fleming, T.P. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  42. Arsenite cocarcinogenesis: an animal model derived from genetic toxicology studies. Rossman, T.G., Uddin, A.N., Burns, F.J., Bosland, M.C. Environ. Health Perspect. (2002) [Pubmed]
  43. Safety of ticarcillin disodium/potassium clavulanate. Tasker, T.C., Cockburn, A., Jackson, D., Mellows, G., White, D. J. Antimicrob. Chemother. (1986) [Pubmed]
  44. Unexpected suppression of total digoxin concentrations by cross-reactants in the microparticle enzyme immunoassay: elimination of interference by monitoring free digoxin concentration. Dasgupta, A., Scott, J. Am. J. Clin. Pathol. (1998) [Pubmed]
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