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Chemical Compound Review: 

Histargin     (2S)-2-[2-[[(1S)-1-carboxy-2- (3H-imidazol...

Synonyms: AG-H-81477, LS-75841, CTK5H2356, AC1L3T5H, 93361-66-1
 
 
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Disease relevance of Histargin

  • Histargin, a new inhibitor of carboxypeptidase B, produced by actinomycetes [1].
  • The structure of histargin, an inhibitor of carboxypeptidase B, produced by Streptomyces roseoviridis MF118-A5 strain, has been defined as N-[(S)-1-carboxy-4-guanidinobutyl]-N'-[(S)-1-carboxy-2-(imidazol-4 -yl) ethyl]ethylenediamine, by spectral analysis and chemical synthesis [2].

References

  1. Histargin, a new inhibitor of carboxypeptidase B, produced by actinomycetes. Umezawa, H., Aoyagi, T., Ogawa, K., Iinuma, H., Naganawa, H., Hamada, M., Takeuchi, T. J. Antibiot. (1984) [Pubmed]
  2. The structure of histargin. Ogawa, K., Naganawa, H., Iinuma, H., Aoyagi, T., Umezawa, H. J. Antibiot. (1984) [Pubmed]
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