Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-E-80590 4-[(3,4-dimethoxyphenyl) methyl]imidazolidi...

Synonyms: SureCN11556653, CTK4F6831, AC1L3UC2, Ro 7 2956, Ro 7-2956, ...

Linden, J. et al., Podzuweit, T. et al.

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Disease relevance of Ro 7-2956

Arrhythmias were induced by 8-Br-cAMP (5 X 10(-2) M) in the presence of inhibitor of cyclic nucleotide phosphodiesterase (3 X 10(-4) M Ro 7-2956) within 30 min [1].

High impact information on Ro 7-2956

Interactions between MCh, Angiotensin II and a nonmethylxanthine phosphodiesterase inhibitor (Ro 7-2956) were assessed by measuring tissue levels of cyclic nucleotides and the Vmax of slow action potentials [2].

References

Catecholamine/cyclic AMP/Ca2+ induces arrhythmias in the healthy pig heart. Podzuweit, T., Louw, G.C., Shanley, B.C. Advances in myocardiology. (1980) [Pubmed]
Sensitivity of Ca-dependent slow action potentials to methacholine is induced by phosphodiesterase inhibitors in embryonic chick ventricles. Linden, J., Vogel, S., Sperelakis, N. J. Pharmacol. Exp. Ther. (1982) [Pubmed]

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