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PDE3A  -  phosphodiesterase 3A, cGMP-inhibited

Sus scrofa

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Disease relevance of PDE3A


High impact information on PDE3A


Biological context of PDE3A


Anatomical context of PDE3A


Associations of PDE3A with chemical compounds


Regulatory relationships of PDE3A


Other interactions of PDE3A


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  2. Catecholamine/cyclic AMP/Ca2+ induces arrhythmias in the healthy pig heart. Podzuweit, T., Louw, G.C., Shanley, B.C. Advances in myocardiology. (1980) [Pubmed]
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  4. Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes. Choi, Y.H., Ekholm, D., Krall, J., Ahmad, F., Degerman, E., Manganiello, V.C., Movsesian, M.A. Biochem. J. (2001) [Pubmed]
  5. Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells. Fuhrmann, M., Jahn, H.U., Seybold, J., Neurohr, C., Barnes, P.J., Hippenstiel, S., Kraemer, H.J., Suttorp, N. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
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  7. Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity. Sircar, I., Weishaar, R.E., Kobylarz, D., Moos, W.H., Bristol, J.A. J. Med. Chem. (1987) [Pubmed]
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  12. Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells. Souness, J.E., Diocee, B.K., Martin, W., Moodie, S.A. Biochem. J. (1990) [Pubmed]
  13. Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents. Weishaar, R.E., Burrows, S.D., Kobylarz, D.C., Quade, M.M., Evans, D.B. Biochem. Pharmacol. (1986) [Pubmed]
  14. Multiple mechanisms of xanthine actions on airway reactivity. Howell, R.E. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
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  16. Inhibition of separated forms of phosphodiesterases from pig coronary arteries by uracils and by 7-substituted derivatives of 1-methyl-3-isobutylxanthine. Garst, J.E., Kramer, G.L., Wu, Y.J., Wells, J.N. J. Med. Chem. (1976) [Pubmed]
  17. Pulmonary antiallergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea pigs. Howell, R.E., Sickels, B.D., Woeppel, S.L. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  18. Interaction of psychotropic drugs with phospholipids. Kanno, K., Sasaki, Y. Biochem. Pharmacol. (1982) [Pubmed]
  19. Calcium-dependent cyclic nucleotide phosphodiesterase from brain: comparison of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate as substrates. Brostrom, C.O., Wolff, D.J. Arch. Biochem. Biophys. (1976) [Pubmed]
  20. Benzylisoquinoline compounds inhibit the ability of calmodulin to activate cyclic nucleotide phosphodiesterase. Hu, Z.Y., Chen, S.L., Hao, Z.G., Huang, W.L., Peng, S.X. Cell. Signal. (1989) [Pubmed]
  21. Effects of inhibitors of cyclic nucleotide phosphodiesterase on actions of cholecystokinin, bombesin, and carbachol on pancreatic acini. Gardner, J.D., Sutliff, V.E., Walker, M.D., Jensen, R.T. Am. J. Physiol. (1983) [Pubmed]
  22. Differences in the association of calmodulin with cyclic nucleotide phosphodiesterase in relaxed and contracted arterial strips. Saitoh, Y., Hardman, J.G., Wells, J.N. Biochemistry (1985) [Pubmed]
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