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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AC1L4A8G     phenylazanyl ethanoate

Synonyms: C02709, 71825-04-2, anilino acetate, N-(Acetyloxy)benzenamine, Benzenamine, N-(acetyloxy)-
 
 
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Disease relevance of acetic acid anilino ester

  • In the presence of AHAT, an enzyme that activates N-arylhydroxamic acids to electrophilic N-acetoxyarylamine intermediates, both compounds caused toxicity and mutagenicity in TK6 cells [1].
 

High impact information on acetic acid anilino ester

References

  1. Comparative toxicity and mutagenicity of N-hydroxy-2-acetylaminofluorene and 7-acetyl-N-hydroxy-2-acetylaminofluorene in human lymphoblasts. Babson, J.R., Gavitt, N.E., Boteju, L.W., Hanna, P.E. Mutat. Res. (1992) [Pubmed]
  2. Activation of tinidazole, an antiprotozoal drug to a mutagen by mammalian liver S9. Gupta, R.L., Vats, V., Juneja, T.R. Mutat. Res. (1996) [Pubmed]
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