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Chemical Compound Review

Lidorestat     2-[3-[(4,5,7- trifluorobenzothiazol-2...

Synonyms: IDD-676, CHEMBL363387, SureCN419032, AG-E-73177, EML 676, ...
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Disease relevance of Lidorestat


High impact information on Lidorestat

  • The lead candidate, 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat, 9) inhibits aldose reductase with an IC(50) of 5 nM, while being 5400 times less active against aldehyde reductase, a related enzyme involved in the detoxification of reactive aldehydes [2].


  1. Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor. Calcutt, N.A., Freshwater, J.D., Mizisin, A.P. Diabetologia (2004) [Pubmed]
  2. Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. Van Zandt, M.C., Jones, M.L., Gunn, D.E., Geraci, L.S., Jones, J.H., Sawicki, D.R., Sredy, J., Jacot, J.L., Dicioccio, A.T., Petrova, T., Mitschler, A., Podjarny, A.D. J. Med. Chem. (2005) [Pubmed]
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