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Chemical Compound Review:

N-8nornic 1-[(2S)-2-pyridin-3- ylpyrrolidin-1...

Synonyms: AC1Q5KFF, AR-1L2858, AR-1L2859, AC1L4R3U, N-Octanoylnornicotine, ...

Bullion, K. et al., Osawa, Y. et al.

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Disease relevance of N-n-Octanoylnornicotine

Toxicity studies indicated relatively low toxicity with LD50 for N-n-octanoylnornicotine = 367 mg/kg body weight [1].

High impact information on N-n-Octanoylnornicotine

Competitive inhibition of human placental aromatase by N-n-octanoylnornicotine and other nornicotine derivatives [2].

References

Aromatase inhibitors in cigarette smoke, tobacco leaves and other plants. Osawa, Y., Tochigi, B., Tochigi, M., Ohnishi, S., Watanabe, Y., Bullion, K., Osawa, G., Nakabayashi, Y., Yarborough, C. J. Enzym. Inhib. (1990) [Pubmed]
Competitive inhibition of human placental aromatase by N-n-octanoylnornicotine and other nornicotine derivatives. Bullion, K., Ohnishi, S., Osawa, Y. Endocr. Res. (1991) [Pubmed]

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