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Chemical Compound Review:

L-SOS (2S)-2-amino-3-sulfooxy- propanoic acid

Synonyms: CHEMBL28885, AG-K-50025, CHEBI:15829, AC1L4VAG, AC1Q6XIM, ...

Strísovský, K. et al., Pullan, L.M. et al., Wang, G.J. et al., Thomsen, C. et al., Sadzuka, Y. et al., et al.

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Disease relevance of O-sulfonato-L-serine

Notably, a low concentration of L-serine-O-sulfate actually increased the uptake of glutamate in P388 leukemia cells [1].

High impact information on O-sulfonato-L-serine

Likewise, l-serine O-sulfate inhibits the synthesis of d-serine in primary astrocyte cultures [2].
Dihydrokainate was a potent inhibitor (Ki = 8 +/- 1 microM), and L-serine-O-sulfate produced a GLT1-mediated current with a K(m) value of 312 +/- 33 microM [3].
L-Serine-O-sulfate was an agonist at mGluR1a (EC50 = 70 microM), mGluR2 (EC50 = 25 microM), and mGluR4 (EC50 = 324 microM) [4].
L-Homocysteate, which has been found in the brain, and L-serine-O-sulfate are selective agonists and could serve as endogenous neurotransmitters at the NMDA receptor [5].

Analytical, diagnostic and therapeutic context of O-sulfonato-L-serine

Using a bacterial expression system and ATP-agarose affinity chromatography, we have generated a pure and active recombinant mSR and investigated its substrate and reaction specificity in vitro by analyzing a systematic series of compounds derived from l-Ser and l-serine-O-sulfate [6].

References

Effects of glutamate transporter inhibitors on the antitumor activity of doxorubicin. Sadzuka, Y., Yamashita, Y., Sonobe, T. Clin. Cancer Res. (2002) [Pubmed]
A new strategy to decrease N-methyl-D-aspartate (NMDA) receptor coactivation: inhibition of D-serine synthesis by converting serine racemase into an eliminase. Panizzutti, R., De Miranda, J., Ribeiro, C.S., Engelender, S., Wolosker, H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
High affinity glutamate transport in rat cortical neurons in culture. Wang, G.J., Chung, H.J., Schnuer, J., Pratt, K., Zable, A.C., Kavanaugh, M.P., Rosenberg, P.A. Mol. Pharmacol. (1998) [Pubmed]
L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a. Thomsen, C., Hansen, L., Suzdak, P.D. J. Neurochem. (1994) [Pubmed]
Excitatory amino acid receptor potency and subclass specificity of sulfur-containing amino acids. Pullan, L.M., Olney, J.W., Price, M.T., Compton, R.P., Hood, W.F., Michel, J., Monahan, J.B. J. Neurochem. (1987) [Pubmed]
Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity. Strísovský, K., Jirásková, J., Mikulová, A., Rulísek, L., Konvalinka, J. Biochemistry (2005) [Pubmed]

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