Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AR-1J3154 (2S,3R,4R,5S)-3,4,5- trihydroxy-2-methoxy...

Synonyms: AC1L5413, 2-O-Methylfucose, L-Galactose, 6-deoxy-2-O-methyl-

Hunter, S.W. et al., Stepkowski, T. et al., López-Lara, I.M. et al., Sanjuan, J. et al.

Stepkowski, Swiderska, Miedzinska, Czaplińska, Swiderski, Biesiadka, Legocki,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 2-O-Methylfucose

A 2-O-methylfucose moiety is present in the lipo-oligosaccharide nodulation signal of Bradyrhizobium japonicum [1].

High impact information on 2-O-Methylfucose

A mutation in nodZ of Bradyrhizobium japonicum results in the synthesis of nodulation signals lacking the wild-type 2-O-methylfucose residue at the reducting-terminal N-acetylglucosamine [2].
Gas-liquid chromatography-mass spectroscopy showed that the product from M. kansasii is composed of 2,4-di-O-methylrhamnose, 2-O-methylrhamnose, and 2-O-methylfucose, whereas that from M. leprae contains 2,3-di-O-methylrhamnose, 3-O-methylrhamnose, and 3,6-di-O-methylglucose [3].
During this process the loss of a noel gene and the acquisition of a nolL gene could be regarded as an adaptation towards these legumes that responded to Nod factors carrying 4-O-acetylfucose rather than 2-O-methylfucose [4].

References

A 2-O-methylfucose moiety is present in the lipo-oligosaccharide nodulation signal of Bradyrhizobium japonicum. Sanjuan, J., Carlson, R.W., Spaink, H.P., Bhat, U.R., Barbour, W.M., Glushka, J., Stacey, G. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
NodZ of Bradyrhizobium extends the nodulation host range of Rhizobium by adding a fucosyl residue to nodulation signals. López-Lara, I.M., Blok-Tip, L., Quinto, C., Garcia, M.L., Stacey, G., Bloemberg, G.V., Lamers, G.E., Lugtenberg, B.J., Thomas-Oates, J.E., Spaink, H.P. Mol. Microbiol. (1996) [Pubmed]
A novel phenolic glycolipid from Mycobacterium leprae possibly involved in immunogenicity and pathogenicity. Hunter, S.W., Brennan, P.J. J. Bacteriol. (1981) [Pubmed]
Low sequence similarity and gene content of symbiotic clusters of Bradyrhizobium sp. WM9 (Lupinus) indicate early divergence of "lupin" lineage in the genus Bradyrhizobium. Stepkowski, T., Swiderska, A., Miedzinska, K., Czaplińska, M., Swiderski, M., Biesiadka, J., Legocki, A.B. Antonie Van Leeuwenhoek (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share