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Chemical Compound Review:

BENZYLACETONE 4-phenylbutan-2-one

Synonyms: SureCN1346, NSC-813, AGN-PC-00AN0R, NSC813, QSPL 147, ...

Motohashi, N. et al., Kitamura, S. et al.

Kitamura, Okamoto, Takeshita, Ohta, Motohashi, Ashihara, Yamagami, Saito,

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High impact information on beta-Phenylethyl methyl ketone

Benzalacetone and 4-phenyl-3-butyn-2-one suppressed the UV-induced mutagenesis, but benzylacetone and trans-beta-methyl styrene scarcely inhibited the mutagenesis: an alpha, beta-double or triple-bonded carbonyl system was necessary for the antimutagenic activity [1].

Analytical, diagnostic and therapeutic context of beta-Phenylethyl methyl ketone

In both species, the double bond-reduced product, 4-phenyl-2-butanone (PBA), was detected by HPLC as the predominant species in blood after i.v. administration of PBO [2].

References

Antimutagenic effects of dehydrozingerone and its analogs on UV-induced mutagenesis in Escherichia coli. Motohashi, N., Ashihara, Y., Yamagami, C., Saito, Y. Mutat. Res. (1997) [Pubmed]
Reductive metabolism In vivo of trans-4-phenyl-3-buten-2-one in rats and dogs. Kitamura, S., Okamoto, Y., Takeshita, M., Ohta, S. Drug Metab. Dispos. (1999) [Pubmed]

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