Disease relevance of trans-Benzylideneacetone

• Contrary to the results obtained in the Salmonella assay in the tests with alkoxyresorufins no extraordinary counteracting effects of isoflavones, of hydroxyl groups at carbons 6 or 2' or of the elimination of ring B (benzylideneacetone) were detected [1].
• Structure-antimutagenic activity relationships of benzalacetone derivatives against UV-induced mutagenesis in E. coli WP2uvrA and gamma-induced mutagenesis in Salmonella typhimurium TA2638 [2].
• Structure-activity relationship in potentially anti-tumor promoting benzalacetone derivatives, as assayed by the epstein-barr virus early antigen activation [3].
• Identification of an antibacterial compound, benzylideneacetone, from Xenorhabdus nematophila against major plant-pathogenic bacteria [4].

High impact information on trans-Benzylideneacetone

• Michael addition to alpha,beta-unsaturated carbonyls is exemplified by a model substance, trans-4-phenylbut-3-en-2-one, and a toxic compound that is formed during oxidative stress, 4-hydroxy-2-undecenal [5].
• Benzalacetone synthase from Rheum palmatum efficiently catalyzed condensation of N-methylanthraniloyl-CoA (or anthraniloyl-CoA) with malonyl-CoA (or methylmalonyl-CoA) to produce 4-hydroxy-2(1H)-quinolones, a novel alkaloidal scaffold produced by a type III polyketide synthase (PKS) [6].
• The antimutagenic activities of benzalacetone (4-phenyl-3-buten-2-one) and its structurally-related compounds were evaluated through their use as post-treatments for the UV-induced mutagenesis in Escherichia coli WP2s (uvrA) and the gamma-induced mutagenesis in Salmonella typhimurium TA2638, the latter of which is sensitive to oxidants [2].
• Microsomal carbonyl reductase responsible for reduction of 4-phenyl-3-buten-2-one in rats [7].

Analytical, diagnostic and therapeutic context of trans-Benzylideneacetone

• Site-directed mutagenesis of benzalacetone synthase. The role of the Phe215 in plant type III polyketide synthases [8].
• 4-Phenyl-3-buten-2-one was the main compound identified in the fat samples, and its identification was corroborated by comparison with a standard solution obtained from a commercial source and by HPLC [9].
• Fluorometric determination of benzylideneacetone in fragrance products by liquid chromatography with post-column derivatization [10].

References