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Chemical Compound Review:

PubChem20249 N-cyclohexylpropane-1,3- diamine

Synonyms: SureCN27221, ACMC-1CSW7, AG-B-38586, AG-L-66187, ANW-27547, ...

Beppu, T. et al., Shirahata, A. et al., Huber, M. et al., Chu, P.J. et al.

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Disease relevance of NSC87572

We have assessed the specific role of spermine in breast cancer cell growth using N-cyclohexyl-1,3-diaminopropane (C-DAP), a potent spermine synthase inhibitor [1].
The effects of a potent spermidine synthase inhibitor, trans-4-methylcyclohexylamine (4MCHA), and a spermine synthase inhibitor, N-(3-aminopropyl)cyclohexylamine (APCHA), on polyamine biosynthesis and cell growth have been studied in rat hepatoma cells (HTC cells) in culture [2].

High impact information on NSC87572

Two of them, trans-4-methylcyclohexylamine (4MCHA) and N-(3-aminopropyl)cyclohexylamine (APCHA), selectively and potently inhibited the activities of spermidine synthase and spermine synthase, respectively [3].

Gene context of NSC87572

N-(3-Aminopropyl)cyclohexylamine (APCHA) was originally developed as a spermine synthase inhibitor [4].

References

Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells. Huber, M., Poulin, R. Cancer Res. (1995) [Pubmed]
Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases. Beppu, T., Shirahata, A., Takahashi, N., Hosoda, H., Samejima, K. J. Biochem. (1995) [Pubmed]
Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues. Shirahata, A., Takahashi, N., Beppu, T., Hosoda, H., Samejima, K. Biochem. Pharmacol. (1993) [Pubmed]
Antagonistic effect of N-(3-Aminopropyl)cyclohexylamine on neurotrophic action of spermine in primary cultured rat hippocampal and cerebellar neurons. Chu, P.J., Shirahata, A., Samejima, K., Saito, H., Abe, K. Jpn. J. Pharmacol. (1995) [Pubmed]

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