Chemical Compound Review:
spermine N,N'-bis(3- aminopropyl)butane-1,4- diamine
Synonyms:
Spermina, Spermin, gerontine, neuridine, musculamine, ...
- Identification of spermine as an inhibitor of erythropoiesis in patients with chronic renal failure. Radtke, H.W., Rege, A.B., LaMarche, M.B., Bartos, D., Bartos, F., Campbell, R.A., Fisher, J.W. J. Clin. Invest. (1981)
- DNA delivery by phage as a strategy for encapsulating toroidal condensates of arbitrary size into liposomes. Lambert, O., Letellier, L., Gelbart, W.M., Rigaud, J.L. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Distribution of spermidine and spermine in blood from cystic fibrosis patients and control subjects. Cohen, L.F., Lundgren, D.W., Farrell, P.M. Blood (1976)
- Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells. Huber, M., Poulin, R. Cancer Res. (1995)
- Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells. Kramer, D.L., Fogel-Petrovic, M., Diegelman, P., Cooley, J.M., Bernacki, R.J., McManis, J.S., Bergeron, R.J., Porter, C.W. Cancer Res. (1997)
- Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex. Ragnarsson, L., Mortensen, M., Dodd, P.R., Lewis, R.J. J. Neurochem. (2002)
- Spermine and aminoguanidine protect cells from chromosome aberrations induced by adenovirus during the G2 phase of the cell cycle. Bellett, A.J., Waldron-Stevens, L.K., Braithwaite, A.W., Cheetham, B.F. Chromosoma (1982)
- Brain lesions and delayed water maze learning deficits after intracerebroventricular spermine. Conway, E.L. Brain Res. (1998)
- Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders. Vivó, M., de Vera, N., Cortés, R., Mengod, G., Camón, L., Martínez, E. Neurosci. Lett. (2001)
- Cyclic changes of plasma spermine concentrations in women. Gilad, V.H., Halperin, R., Chen-Levy, Z., Gilad, G.M. Life Sci. (2002)
- Identification of a thymic inhibitor ('chalone') of lymphocyte transformation as a spermine complex. Allen, J.C., Smith, C.J., Curry, M.C., Gaugas, J.M. Nature (1977)
- Polyamine regulation of N-methyl-D-aspartate receptor channels. Rock, D.M., Macdonald, R.L. Annu. Rev. Pharmacol. Toxicol. (1995)
- Casein kinase-II regulates NMDA channel function in hippocampal neurons. Lieberman, D.N., Mody, I. Nat. Neurosci. (1999)
- Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response. Zhang, M., Caragine, T., Wang, H., Cohen, P.S., Botchkina, G., Soda, K., Bianchi, M., Ulrich, P., Cerami, A., Sherry, B., Tracey, K.J. J. Exp. Med. (1997)
- Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Takenoshita, S., Matsuzaki, S., Nakano, G., Kimura, H., Hoshi, H., Shoda, H., Nakamura, T. Cancer Res. (1984)
- Spermine-induced variations in the adenosine 5'-diphosphate ribosylation patterns of nuclear proteins from rat liver and hepatoma. Perrella, F.W., Lea, M.A. Cancer Res. (1979)
- Aminoacyl transfer RNA formation. V. Effect of ethylenediaminetetraacetate on isoleucyl transfer RNA formation stimulated by either spermine or Mg2+. Takeda, Y., Onishi, T. J. Biol. Chem. (1975)
- Appetite suppression and weight reduction by a centrally active aminosterol. Ahima, R.S., Patel, H.R., Takahashi, N., Qi, Y., Hileman, S.M., Zasloff, M.A. Diabetes (2002)
- Unraveling new features of clindamycin interaction with functional ribosomes and dependence of the drug potency on polyamines. Kouvela, E.C., Petropoulos, A.D., Kalpaxis, D.L. J. Biol. Chem. (2006)
- Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor. Williams, K., Dawson, V.L., Romano, C., Dichter, M.A., Molinoff, P.B. Neuron (1990)
- Spermine regulates N-methyl-D-aspartate receptor desensitization. Lerma, J. Neuron (1992)
- Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Sullivan, J.M., Traynelis, S.F., Chen, H.S., Escobar, W., Heinemann, S.F., Lipton, S.A. Neuron (1994)
- Insulin receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport system in rat adipocytes. Garvey, W.T., Olefsky, J.M., Marshall, S. J. Clin. Invest. (1985)
- Mutagenesis rescues spermine and Zn2+ potentiation of recombinant NMDA receptors. Zheng, X., Zhang, L., Durand, G.M., Bennett, M.V., Zukin, R.S. Neuron (1994)
- Increased spermidine or spermine level is essential for hepatocyte growth factor-induced DNA synthesis in cultured rat hepatocytes. Higaki, I., Matsui-Yuasa, I., Terakura, M., Kinoshita, H., Otani, S. Gastroenterology (1994)
- Alcohol, amino acids, and albumin synthesis. II. Alcohol inhibition of albumin synthesis reversed by arginine and spermine. Oratz, M., Rothschild, M.A., Schreiber, S.S. Gastroenterology (1976)
- Stabilization of erythrocyte membranes by polyamines. Ballas, S.K., Mohandas, N., Marton, L.J., Shohet, S.B. Proc. Natl. Acad. Sci. U.S.A. (1983)
- Histamine potentiates N-methyl-D-aspartate responses in acutely isolated hippocampal neurons. Vorobjev, V.S., Sharonova, I.N., Walsh, I.B., Haas, H.L. Neuron (1993)
- Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor. Cheng, S.X., Geibel, J.P., Hebert, S.C. Gastroenterology (2004)
- Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase. Chattopadhyay, M.K., Tabor, C.W., Tabor, H. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Spermidine or spermine is essential for the aerobic growth of Saccharomyces cerevisiae. Balasundaram, D., Tabor, C.W., Tabor, H. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene. Lorenz, B., Francis, F., Gempel, K., Böddrich, A., Josten, M., Schmahl, W., Schmidt, J., Lehrach, H., Meitinger, T., Strom, T.M. Hum. Mol. Genet. (1998)
- Screening for modulators of spermine tolerance identifies Sky1, the SR protein kinase of Saccharomyces cerevisiae, as a regulator of polyamine transport and ion homeostasis. Erez, O., Kahana, C. Mol. Cell. Biol. (2001)
- Antibody to spermine: a natural biological constituent. Bartos, D., Bartos, F., Campbell, R.A., Grettie, D.P., Smejtek, P. Science (1980)
- Visually driven modulation of glutamatergic synaptic transmission is mediated by the regulation of intracellular polyamines. Aizenman, C.D., Muñoz-Elías, G., Cline, H.T. Neuron (2002)
- Spermine stimulation of CCl4 depressed protein synthesis in rabbits. Oratz, M., Rothschild, M.A., Schreiber, S.S., Lane, B.P. Gastroenterology (1980)
- Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Porter, C.W., Bernacki, R.J., Miller, J., Bergeron, R.J. Cancer Res. (1993)