High impact information on CCRIS 7691

• The slow hydrolysis observed for DMENU and TMNU suggests that the latter route of hydrolysis is applicable [1].
• Consistent with this DMENU and TMNU gave negative results in the NBP alkylation test while the parent compounds gave an instantaneous deep blue coloration [1].
• ENU and MNU are potent micronucleus-inducing agents to the mouse bone marrow, and given the above data, it was expected that DMENU and TMNU would show weak or no activity in that assay [1].

Biological context of CCRIS 7691

• Studies of the rate of hydrolysis of these four compounds revealed ENU and MNU to have half-lives of 8 min, while the alkylated analogues (DMENU and TMNU) had half-lives of 25 and 41 days, respectively [1].

References