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Chemical Compound Review

CCRIS 7691     1,1,3-trimethyl-3-nitroso-urea

Synonyms: AG-F-19226, CTK4H2987, LS-160772, BRN 2077277, AC1L2D83, ...
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High impact information on CCRIS 7691

  • The slow hydrolysis observed for DMENU and TMNU suggests that the latter route of hydrolysis is applicable [1].
  • Consistent with this DMENU and TMNU gave negative results in the NBP alkylation test while the parent compounds gave an instantaneous deep blue coloration [1].
  • ENU and MNU are potent micronucleus-inducing agents to the mouse bone marrow, and given the above data, it was expected that DMENU and TMNU would show weak or no activity in that assay [1].

Biological context of CCRIS 7691

  • Studies of the rate of hydrolysis of these four compounds revealed ENU and MNU to have half-lives of 8 min, while the alkylated analogues (DMENU and TMNU) had half-lives of 25 and 41 days, respectively [1].


  1. Unexpected genetic toxicity to rodents of the N',N'-dimethyl analogues of MNU and ENU. Tinwell, H., Paton, D., Guttenplan, J.B., Ashby, J. Environ. Mol. Mutagen. (1996) [Pubmed]
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