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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Bone Marrow

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Disease relevance of Bone Marrow


Psychiatry related information on Bone Marrow


High impact information on Bone Marrow

  • In a number of allogeneic transplant models (heart, skin, bone marrow) anti-CD4 (+/- CD8) antibodies can be shown to block the rejection process while selectively promoting the development of CD4+ regulatory T cells responsible for a dominant tolerance that is reflected in findings of linked suppression and infectious tolerance [11].
  • The dramatic reversal of EBV-driven lymphoproliferations in bone marrow transplant patients following CTL infusion demonstrates the potential of this approach, and here we discuss prospects for its extension to other EBV-positive tumors in which the immunodominant EBNA3A, 3B, 3C proteins are not expressed [12].
  • Membrane-bound expression of an Ig-like complex of microH chains and surrogate L chains appears to be needed to generate the 50-70 million pre B-II cells in bone marrow [13].
  • The initial protocols were aimed at the correction of peripheral blood T lymphocytes, but recent strategies are attempting ADA gene transfer into peripheral blood or bone marrow stem cells [14].
  • Both CSF-1 and GM-CSF are responsible for transition of cells of the M phi lineage from bone marrow to blood, and from blood to tissues, and have a critical extramedullary role [15].

Chemical compound and disease context of Bone Marrow


Biological context of Bone Marrow


Anatomical context of Bone Marrow


Associations of Bone Marrow with chemical compounds


Gene context of Bone Marrow

  • Fanconi anaemia (FA) is an autosomal recessive disorder associated with diverse developmental abnormalities, bone-marrow failure and predisposition to cancer [34].
  • E2A-PBX1 also markedly altered lymphoid development in pretumorous animals, reducing the number of thymocytes and bone marrow B lineage progenitors to 20% of normal levels [35].
  • We have generated Gfi1-deficient mice (Gfi1-/-) and show that these animals are severely neutropenic and accumulate immature monocytic cells in blood and bone marrow [36].
  • Transplantation of wild-type bone marrow rescued the impaired angiogenesis and collateral growth in Pgf-/- mice, indicating that PlGF might have contributed to vessel growth in the adult by mobilizing bone-marrow-derived cells [37].
  • Re-expression of TSP-1 and TSP-2 in mice transplanted with wild-type bone marrow corrected the angiogenic abnormalities in Akt1(-/-) mice [38].

Analytical, diagnostic and therapeutic context of Bone Marrow


  1. Serum cyclosporine concentration and risk of acute graft-versus-host disease after allogeneic marrow transplantation. Yee, G.C., Self, S.G., McGuire, T.R., Carlin, J., Sanders, J.E., Deeg, H.J. N. Engl. J. Med. (1988) [Pubmed]
  2. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. Braun, S., Pantel, K., Müller, P., Janni, W., Hepp, F., Kentenich, C.R., Gastroph, S., Wischnik, A., Dimpfl, T., Kindermann, G., Riethmüller, G., Schlimok, G. N. Engl. J. Med. (2000) [Pubmed]
  3. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Schuler, W., Weiler, I.J., Schuler, A., Phillips, R.A., Rosenberg, N., Mak, T.W., Kearney, J.F., Perry, R.P., Bosma, M.J. Cell (1986) [Pubmed]
  4. Circulating activated suppressor T lymphocytes in aplastic anemia. Zoumbos, N.C., Gascón, P., Djeu, J.Y., Trost, S.R., Young, N.S. N. Engl. J. Med. (1985) [Pubmed]
  5. The Fanconi anaemia group G gene FANCG is identical with XRCC9. de Winter, J.P., Waisfisz, Q., Rooimans, M.A., van Berkel, C.G., Bosnoyan-Collins, L., Alon, N., Carreau, M., Bender, O., Demuth, I., Schindler, D., Pronk, J.C., Arwert, F., Hoehn, H., Digweed, M., Buchwald, M., Joenje, H. Nat. Genet. (1998) [Pubmed]
  6. Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Srivastava, A., Poonkuzhali, B., Shaji, R.V., George, B., Mathews, V., Chandy, M., Krishnamoorthy, R. Blood (2004) [Pubmed]
  7. Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression. Terai, S., Aoki, H., Ashida, K., Thorgeirsson, S.S. Hepatology (2000) [Pubmed]
  8. Complex visual hallucinations and cyclosporine. Noll, R.B., Kulkarni, R. Arch. Neurol. (1984) [Pubmed]
  9. Bone marrow triglyceride accumulation and hormonal changes during long-term alcohol intake in male and female rats. Wezeman, F.H., Gong, Z. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  10. Dose- and time-response relationships of triethylenemelamine-induced chromosomal aberrations in rat bone marrow cells. Levine, B.S., Pergament, E., Driscoll, K. Toxicol. Lett. (1982) [Pubmed]
  11. How do monoclonal antibodies induce tolerance? A role for infectious tolerance? Waldmann, H., Cobbold, S. Annu. Rev. Immunol. (1998) [Pubmed]
  12. Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection. Rickinson, A.B., Moss, D.J. Annu. Rev. Immunol. (1997) [Pubmed]
  13. Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Melchers, F., Haasner, D., Grawunder, U., Kalberer, C., Karasuyama, H., Winkler, T., Rolink, A.G. Annu. Rev. Immunol. (1994) [Pubmed]
  14. Gene therapy of the immune system. Cournoyer, D., Caskey, C.T. Annu. Rev. Immunol. (1993) [Pubmed]
  15. Cytokine regulation of the macrophage (M phi) system studied using the colony stimulating factor-1-deficient op/op mouse. Wiktor-Jedrzejczak, W., Gordon, S. Physiol. Rev. (1996) [Pubmed]
  16. Transfer of allergen-specific IgE-mediated hypersensitivity with allogeneic bone marrow transplantation. Agosti, J.M., Sprenger, J.D., Lum, L.G., Witherspoon, R.P., Fisher, L.D., Storb, R., Henderson, W.R. N. Engl. J. Med. (1988) [Pubmed]
  17. A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants; The City of Hope-Stanford-Syntex CMV Study Group. Schmidt, G.M., Horak, D.A., Niland, J.C., Duncan, S.R., Forman, S.J., Zaia, J.A. N. Engl. J. Med. (1991) [Pubmed]
  18. Serum lactate dehydrogenase and bone marrow involvement in small-cell carcinoma of the lung. Doll, D.C. N. Engl. J. Med. (1985) [Pubmed]
  19. Antibodies against the acetylcholine receptor in hematologic disorders: implications for the development of myasthenia gravis after bone marrow grafting. Lefvert, A.K., Björkholm, M. N. Engl. J. Med. (1987) [Pubmed]
  20. Treatment of steroid-resistant acute graft-vs-host disease by in vivo administration of an anti-T-cell ricin A chain immunotoxin. Kernan, N.A., Byers, V., Scannon, P.J., Mischak, R.P., Brochstein, J., Flomenberg, N., Dupont, B., O'Reilly, R.J. JAMA (1988) [Pubmed]
  21. SOCS3 is essential in the regulation of fetal liver erythropoiesis. Marine, J.C., McKay, C., Wang, D., Topham, D.J., Parganas, E., Nakajima, H., Pendeville, H., Yasukawa, H., Sasaki, A., Yoshimura, A., Ihle, J.N. Cell (1999) [Pubmed]
  22. Severe combined immunodeficiency and adenosine deaminase deficiency. Parkman, R., Gelfand, E.W., Rosen, F.S., Sanderson, A., Hirschhorn, R. N. Engl. J. Med. (1975) [Pubmed]
  23. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Rolink, A.G., Nutt, S.L., Melchers, F., Busslinger, M. Nature (1999) [Pubmed]
  24. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S., Kitamura, Y., Yoshida, N., Kikutani, H., Kishimoto, T. Nature (1996) [Pubmed]
  25. Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Matsunaga, T., Takemoto, N., Sato, T., Takimoto, R., Tanaka, I., Fujimi, A., Akiyama, T., Kuroda, H., Kawano, Y., Kobune, M., Kato, J., Hirayama, Y., Sakamaki, S., Kohda, K., Miyake, K., Niitsu, Y. Nat. Med. (2003) [Pubmed]
  26. The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Karasuyama, H., Rolink, A., Shinkai, Y., Young, F., Alt, F.W., Melchers, F. Cell (1994) [Pubmed]
  27. Suppression of erythroid-colony formation by lymphocytes from patients with aplastic anemia. Hoffman, R., Zanjani, E.D., Lutton, J.D., Zalusky, R., Wasserman, L.R. N. Engl. J. Med. (1977) [Pubmed]
  28. Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers. Bensinger, W.I., Martin, P.J., Storer, B., Clift, R., Forman, S.J., Negrin, R., Kashyap, A., Flowers, M.E., Lilleby, K., Chauncey, T.R., Storb, R., Appelbaum, F.R. N. Engl. J. Med. (2001) [Pubmed]
  29. Autocrine beta-related interferon controls c-myc suppression and growth arrest during hematopoietic cell differentiation. Resnitzky, D., Yarden, A., Zipori, D., Kimchi, A. Cell (1986) [Pubmed]
  30. Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver--conditioned medium. Zsebo, K.M., Wypych, J., McNiece, I.K., Lu, H.S., Smith, K.A., Karkare, S.B., Sachdev, R.K., Yuschenkoff, V.N., Birkett, N.C., Williams, L.R. Cell (1990) [Pubmed]
  31. Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. The German Aplastic Anemia Study Group. Frickhofen, N., Kaltwasser, J.P., Schrezenmeier, H., Raghavachar, A., Vogt, H.G., Herrmann, F., Freund, M., Meusers, P., Salama, A., Heimpel, H. N. Engl. J. Med. (1991) [Pubmed]
  32. Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER. Boehmelt, G., Madruga, J., Dörfler, P., Briegel, K., Schwarz, H., Enrietto, P.J., Zenke, M. Cell (1995) [Pubmed]
  33. Bone-marrow depression with cimetidine plus carmustine. Selker, R.G., Moore, P., Lodolce, D. N. Engl. J. Med. (1978) [Pubmed]
  34. Localisation of the Fanconi anaemia complementation group A gene to chromosome 16q24.3. Pronk, J.C., Gibson, R.A., Savoia, A., Wijker, M., Morgan, N.V., Melchionda, S., Ford, D., Temtamy, S., Ortega, J.J., Jansen, S. Nat. Genet. (1995) [Pubmed]
  35. Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. Dedera, D.A., Waller, E.K., LeBrun, D.P., Sen-Majumdar, A., Stevens, M.E., Barsh, G.S., Cleary, M.L. Cell (1993) [Pubmed]
  36. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Karsunky, H., Zeng, H., Schmidt, T., Zevnik, B., Kluge, R., Schmid, K.W., Dührsen, U., Möröy, T. Nat. Genet. (2002) [Pubmed]
  37. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Carmeliet, P., Moons, L., Luttun, A., Vincenti, V., Compernolle, V., De Mol, M., Wu, Y., Bono, F., Devy, L., Beck, H., Scholz, D., Acker, T., DiPalma, T., Dewerchin, M., Noel, A., Stalmans, I., Barra, A., Blacher, S., Vandendriessche, T., Ponten, A., Eriksson, U., Plate, K.H., Foidart, J.M., Schaper, W., Charnock-Jones, D.S., Hicklin, D.J., Herbert, J.M., Collen, D., Persico, M.G. Nat. Med. (2001) [Pubmed]
  38. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Chen, J., Somanath, P.R., Razorenova, O., Chen, W.S., Hay, N., Bornstein, P., Byzova, T.V. Nat. Med. (2005) [Pubmed]
  39. Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) Leukemia Cooperative Groups. Zittoun, R.A., Mandelli, F., Willemze, R., de Witte, T., Labar, B., Resegotti, L., Leoni, F., Damasio, E., Visani, G., Papa, G. N. Engl. J. Med. (1995) [Pubmed]
  40. Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques. Watanabe, M., Reimann, K.A., DeLong, P.A., Liu, T., Fisher, R.A., Letvin, N.L. Nature (1989) [Pubmed]
  41. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Harding, M.W., Galat, A., Uehling, D.E., Schreiber, S.L. Nature (1989) [Pubmed]
  42. The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. den Haan, J.M., Meadows, L.M., Wang, W., Pool, J., Blokland, E., Bishop, T.L., Reinhardus, C., Shabanowitz, J., Offringa, R., Hunt, D.F., Engelhard, V.H., Goulmy, E. Science (1998) [Pubmed]
  43. Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Nutt, S.L., Urbánek, P., Rolink, A., Busslinger, M. Genes Dev. (1997) [Pubmed]
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