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Chemical Compound Review:

Phasvatocin 1-[[19-amino-7,10- bis(aminocarbonylmethyl)...

Synonyms: ACMC-20cpwp, AC1Q5JBQ, AR-1B9591, AC1L4U60, 144334-53-2, ...

Acher, R. et al., Chauvet, J. et al.

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High impact information on Phasvatocin

Asvatocin and phasvatocin display oxytocic activity on rat uterus, about 80 and 5 milliunits per nmol, respectively, and virtually no pressor activity on anesthetized rats [1].
In the spiny dogfish, aspargtocin ([Asn4]-oxytocin) and valitocin ([Val(8)]-oxytocin) have been characterized whereas in the spotted dogfish, asvatocin ([Asn(4),Val(8)]-oxytocin) and phasvatocin ([Phe(3),Asn(4),Val(8)]-oxytocin) have been found [2].

References

Special evolution of neurohypophysial hormones in cartilaginous fishes: asvatocin and phasvatocin, two oxytocin-like peptides isolated from the spotted dogfish (Scyliorhinus caniculus). Chauvet, J., Rouille, Y., Chauveau, C., Chauvet, M.T., Acher, R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
Unique evolution of neurohypophysial hormones in cartilaginous fishes: possible implications for urea-based osmoregulation. Acher, R., Chauvet, J., Chauvet, M.T., Rouille, Y. J. Exp. Zool. (1999) [Pubmed]

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