Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Ketohypoglycin 3-(2-methylidenecyclopropyl)- 2-oxo...

Synonyms: AG-K-80767, SureCN2535546, AC1Q5RHB, CTK5A6895, AR-1E6356, ...

Kean, E.A. et al., Melde, K. et al.

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High impact information on Methylenecyclopropylpyruvate

Similarly we confirmed experimentally that methylenecyclopropylacetyl-CoA accumulates in mitochondria incubated with methylenecyclopropylpyruvate [1].
Inhibition of gluconeogenesis in isolated rat liver cells by methylenecyclopropylpyruvate (ketohypoglycin) [2].
5. Many of the effects of methylenecyclopropylpyruvate observed are consistent with inhibition of butyryl-CoA dehydrogenase and of specific CoA-dependent enzymes involved in gluconeogenesis [2].

References

Metabolic consequences of methylenecyclopropylglycine poisoning in rats. Melde, K., Jackson, S., Bartlett, K., Sherratt, H.S., Ghisla, S. Biochem. J. (1991) [Pubmed]
Inhibition of gluconeogenesis in isolated rat liver cells by methylenecyclopropylpyruvate (ketohypoglycin). Kean, E.A., Pogson, C.I. Biochem. J. (1979) [Pubmed]

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