Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Isotrityrosine 2-amino-3-[3-[4-(2-amino-2- carboxy-ethyl)...

Synonyms: AC1L5117, AC1Q509A, 77533-78-9

Fetterer, R.H. et al., Fetterer, R.H. et al.

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High impact information on Isotrityrosine

Tritiated dityrosine and isotrityrosine were detected by high performance liquid chromatography (HPLC) of acid hydrolysates of cuticular proteins from larval Ascaris suum following their 96-hr in vitro incubation in [3H]tyrosine [1].
In a cell-free system, soluble extracts of A. suum larvae also converted radiolabeled tyrosine to dityrosine; isotrityrosine was produced by some extracts [1].
When intact 2M cuticles were labeled with 125I prior to acid hydrolysis, radiolabel was recovered in tyrosine but not dityrosine or isotrityrosine indicating that the tyrosine cross-links are not susceptible to iodination in the intact protein [2].

References

Synthesis of tyrosine-derived cross-links in Ascaris suum cuticular proteins. Fetterer, R.H., Rhoads, M.L., Urban, J.F. J. Parasitol. (1993) [Pubmed]
Tyrosine-derived cross-linking amino acids in the sheath of Haemonchus contortus infective larvae. Fetterer, R.H., Rhoads, M.L. J. Parasitol. (1990) [Pubmed]

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