Disease relevance of Ascaris

• In 11 dogs with beta-adrenergic blockade (propranolol), subsequent Ascaris suum antigen (intravenous) decreased lung tissue histamine 21.5% +/- 5.3% (mean +/- SE), with marked physiologic changes of anaphylaxis [1].
• We conclude that Ascaris and possibly hookworm infection protects against wheeze in young Ethiopian children, and that this effect is not mediated by inhibition of allergen sensitization [2].
• Schistosoma mansoni, Ascaris lumbricoides, hookworm, and Trichuris trichiura egg output and malarial parasitemia were determined and their relation with serum retinol assessed [3].
• Two potent naturally occurring inhibitors are known: pepstatin, a pentapeptide from Streptomyces, and a unique proteinous inhibitor from Ascaris [4].
• When SCH 351591 was administered orally to allergic cynomolgus monkeys at 3 mg/kg, Ascaris suum-induced lung eosinophilia was blocked [5].

Psychiatry related information on Ascaris

• A form of phosphofructokinase (PFK) from Ascaris suum desensitized to hysteresis in the reaction time course and ATP allosteric inhibition has been used to study the activation by fructose 2,6-bisphosphate (F26P2) at varied pH in both reaction directions [6].
• Physical activity and growth of Kenyan school children with hookworm, Trichuris trichiura and Ascaris lumbricoides infections are improved after treatment with albendazole [7].

High impact information on Ascaris

• Components of sterol biosynthesis assembled on the oxygen-avid hemoglobin of Ascaris [8].
• AF1, a sequenced bioactive neuropeptide isolated from the nematode Ascaris suum [9].
• Slow moving proteinase exhibited considerably lower Km values for its interaction with two chromogenic substrates than did cathepsin D. An even greater distinction between the two enzymes was found with the protein inhibitor from Ascaris lumbricoides; the activity of SMP was inhibited very strongly, whereas that of cathepsin D was not affected [10].
• 99% of sera from controls (5 free of parasitic disease, 75 infested with hookworm, Ascaris, Trichuris, and/or Onchocerca) were negative [11].
• Subcellular localization of glyoxylate cycle enzymes in Ascaris suum larvae [12].

Chemical compound and disease context of Ascaris

• In 78 children known to be infected with Ascaris at baseline, the rate of weight gain was 21 per cent greater in children treated with levamisole than in those receiving placebo (p = .03) [13].
• We determined the effect of aerosol challenge with leukotriene D4 (LTD4) on specific lung resistance (sRL) and tracheal mucous velocity (TMV) in conscious sheep with (allergic) and without (nonallergic) Ascaris suum hypersensitivity [14].
• Those with Ascaris infection were treated with pyrantel pamoate in a single dose of 10 mg/kg body weight and all stools passed during 48 hours after treatment were collected in plastic pans and screened for worms which were then sexed and measured [15].
• Nude rats developed eosinophilia following (a) the pulmonary embolization of bovine gammaglobulin (BCG)-coated latex particles, and (b) experimental infection with the nematode parasite Ascaris suum [16].
• The role of nitric oxide (NO) was determined using a NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME; 20 mg/kg bolus and 0.05 mg/kg per min) in the renal sympathetic and hypotensive response to systemic anaphylaxis induced by Ascaris suum antigen (10 mg, i.v.) in naturally sensitized anesthetized dogs [17].

Biological context of Ascaris

• The Ascaris suum phosphofructokinase exhibits hysteretic transitions in the time course for fructose 6-phosphate (F6P) phosphorylation in addition to allosteric properties when assayed at pH values below 8 [18].
• Complex II from mitochondria of the adult parasitic nematode, Ascaris suum, exhibits high fumarate reductase activity and plays a key role in the anaerobic electron transport observed in these organelles [19].
• Ten allergic ewes were subjected to inhalation challenge with Ascaris suum antigen, with and without methylprednisolone pretreatment, administered intravenously either 20 min or 3 hr before antigen challenge [20].
• Solution structure of the motile major sperm protein (MSP) of Ascaris suum - evidence for two manganese binding sites and the possible role of divalent cations in filament formation [21].
• The malic enzyme from muscle mitochondria of the parasitic nematode Ascaris suum is a tetramer of 65 kDa monomers that catalyzes the oxidative decarboxylation of malate to pyruvate and CO2 with NAD cofactor as oxidant [22].

Anatomical context of Ascaris

• The RNA expression pattern of this Caenorhabditis helicase correlates with the presence of germ-line tissue in the parasitic nematode Ascaris lumbricoides var. suum and with the presence of germ cells in wild type and several germ-line mutants of Caenorhabditis [23].
• The regulatory properties of the NAD-dependent malic enzyme from the mitochondria of Ascaris suum have been studied [24].
• We studied the effect of vagus nerve stimulation on the mast cell secretion of histamine after intraarterial (i.a.) administration of Ascaris suum antigen (AA) into the bronchial circulation of 10 randomly selected, natively allergic dogs in vivo [25].
• The collagenous components of Ascaris suum intestinal basement membrane were isolated by extraction with 0.1 M Tris-HC1, 0.5 M NaC1, 0.5% 2-mercaptoethanol, pH 8.3, and Sephacryl S-300 gel filtration [26].
• Contamination of Ascaris body fluid or reagents by bacterial lipopolysaccharide has been ruled out as a source of artefactual data [27].

Associations of Ascaris with chemical compounds

• Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3 [28].
• Localization of choline acetyltransferase within identified motoneurons of the nematode Ascaris [29].
• MHC restriction of the antibody repertoire to secretory antigens, and a major allergen, of the nematode parasite Ascaris [30].
• Identification of a novel dihydrolipoyl dehydrogenase-binding protein in the pyruvate dehydrogenase complex of the anaerobic parasitic nematode, Ascaris suum [31].
• A phosphorylcholine idiotype related to TEPC 15 in mice infected with Ascaris suum [32].

Gene context of Ascaris

• Human infection with Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgR [33].
• For the cox1, ten different electrophoretic profiles were recorded for human Ascaris, and the same number for pig Ascaris, one of them being common to both host species [34].
• Comparison with the related organisms Trichostrongylus colubriformis, Ascaris suum and Pseudoterranova decipiens, provides evidence of gene duplication, intron loss, and functional divergence within the Glo genes of the nematode phylum [35].
• Here we report the cloning and characterisation of a cDNA encoding peroxiredoxin from Ascaris suum (AsPrx) [36].
• Vaccination with recombinant Ascaris suum 24-kilodalton antigen induces a Th1/Th2-mixed type immune response and confers high levels of protection against challenged Ascaris suum lung-stage infection in BALB/c mice [37].

Analytical, diagnostic and therapeutic context of Ascaris

• Therefore, in this study we compared the effects of heparin on antigen-induced bronchconstriction, allergic cutaneous reaction, and histamine release into bronchoalveolar lavage fluid (BAL) in sheep that develop only acute responses or dual responses to inhaled Ascaris suum antigen [38].
• Crystallization of the NAD-dependent malic enzyme from the parasitic nematode Ascaris suum [22].
• Fractionation of Ascaris peptide extracts by high performance liquid chromatography (HPLC), monitoring fractions with a CCK8 radioimmunoassay (RIA), also shows heterogeneity of molecules immunologically related to CCK8 [39].
• 1. The patch-clamp technique was used to examine levamisole-activated channels in muscle vesicles from Ascaris suum [40].
• The distribution of uptake sites for the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the nematode Ascaris suum was examined by autoradiography of 3H-GABA uptake [41].

References