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Disease relevance of Ascaris


Psychiatry related information on Ascaris


High impact information on Ascaris

  • Components of sterol biosynthesis assembled on the oxygen-avid hemoglobin of Ascaris [8].
  • AF1, a sequenced bioactive neuropeptide isolated from the nematode Ascaris suum [9].
  • Slow moving proteinase exhibited considerably lower Km values for its interaction with two chromogenic substrates than did cathepsin D. An even greater distinction between the two enzymes was found with the protein inhibitor from Ascaris lumbricoides; the activity of SMP was inhibited very strongly, whereas that of cathepsin D was not affected [10].
  • 99% of sera from controls (5 free of parasitic disease, 75 infested with hookworm, Ascaris, Trichuris, and/or Onchocerca) were negative [11].
  • Subcellular localization of glyoxylate cycle enzymes in Ascaris suum larvae [12].

Chemical compound and disease context of Ascaris

  • In 78 children known to be infected with Ascaris at baseline, the rate of weight gain was 21 per cent greater in children treated with levamisole than in those receiving placebo (p = .03) [13].
  • We determined the effect of aerosol challenge with leukotriene D4 (LTD4) on specific lung resistance (sRL) and tracheal mucous velocity (TMV) in conscious sheep with (allergic) and without (nonallergic) Ascaris suum hypersensitivity [14].
  • Those with Ascaris infection were treated with pyrantel pamoate in a single dose of 10 mg/kg body weight and all stools passed during 48 hours after treatment were collected in plastic pans and screened for worms which were then sexed and measured [15].
  • Nude rats developed eosinophilia following (a) the pulmonary embolization of bovine gammaglobulin (BCG)-coated latex particles, and (b) experimental infection with the nematode parasite Ascaris suum [16].
  • The role of nitric oxide (NO) was determined using a NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME; 20 mg/kg bolus and 0.05 mg/kg per min) in the renal sympathetic and hypotensive response to systemic anaphylaxis induced by Ascaris suum antigen (10 mg, i.v.) in naturally sensitized anesthetized dogs [17].

Biological context of Ascaris


Anatomical context of Ascaris


Associations of Ascaris with chemical compounds


Gene context of Ascaris

  • Human infection with Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgR [33].
  • For the cox1, ten different electrophoretic profiles were recorded for human Ascaris, and the same number for pig Ascaris, one of them being common to both host species [34].
  • Comparison with the related organisms Trichostrongylus colubriformis, Ascaris suum and Pseudoterranova decipiens, provides evidence of gene duplication, intron loss, and functional divergence within the Glo genes of the nematode phylum [35].
  • Here we report the cloning and characterisation of a cDNA encoding peroxiredoxin from Ascaris suum (AsPrx) [36].
  • Vaccination with recombinant Ascaris suum 24-kilodalton antigen induces a Th1/Th2-mixed type immune response and confers high levels of protection against challenged Ascaris suum lung-stage infection in BALB/c mice [37].

Analytical, diagnostic and therapeutic context of Ascaris


  1. Effect of beta-adrenergic stimulation on experimental canine anaphylaxis in vivo. Mjörndal, T.O., Chesrown, S.E., Frey, M.J., Reed, B.R., Lazarus, S.C., Gold, W.M. J. Allergy Clin. Immunol. (1983) [Pubmed]
  2. Wheezing, allergy, and parasite infection in children in urban and rural Ethiopia. Dagoye, D., Bekele, Z., Woldemichael, K., Nida, H., Yimam, M., Hall, A., Venn, A.J., Britton, J.R., Hubbard, R., Lewis, S.A. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  3. Serum retinol concentrations and Schistosoma mansoni, intestinal helminths, and malarial parasitemia: a cross-sectional study in Kenyan preschool and primary school children. Friis, H., Mwaniki, D., Omondi, B., Muniu, E., Magnussen, P., Geissler, W., Thiong'o, F., Michaelsen, K.F. Am. J. Clin. Nutr. (1997) [Pubmed]
  4. Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development. Kageyama, T. Cell. Mol. Life Sci. (2002) [Pubmed]
  5. Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor. Billah, M.M., Cooper, N., Minnicozzi, M., Warneck, J., Wang, P., Hey, J.A., Kreutner, W., Rizzo, C.A., Smith, S.R., Young, S., Chapman, R.W., Dyke, H., Shih, N.Y., Piwinski, J.J., Cuss, F.M., Montana, J., Ganguly, A.K., Egan, R.W. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  6. Acid-base catalytic mechanism and pH dependence of fructose 2,6-bisphosphate activation of the Ascaris suum phosphofructokinase. Payne, M.A., Rao, G.S., Harris, B.G., Cook, P.F. Biochemistry (1995) [Pubmed]
  7. Physical activity and growth of Kenyan school children with hookworm, Trichuris trichiura and Ascaris lumbricoides infections are improved after treatment with albendazole. Adams, E.J., Stephenson, L.S., Latham, M.C., Kinoti, S.N. J. Nutr. (1994) [Pubmed]
  8. Components of sterol biosynthesis assembled on the oxygen-avid hemoglobin of Ascaris. Sherman, D.R., Guinn, B., Perdok, M.M., Goldberg, D.E. Science (1992) [Pubmed]
  9. AF1, a sequenced bioactive neuropeptide isolated from the nematode Ascaris suum. Cowden, C., Stretton, A.O., Davis, R.E. Neuron (1989) [Pubmed]
  10. Slow moving proteinase. Isolation, characterization, and immunohistochemical localization in gastric mucosa. Samloff, I.M., Taggart, R.T., Shiraishi, T., Branch, T., Reid, W.A., Heath, R., Lewis, R.W., Valler, M.J., Kay, J. Gastroenterology (1987) [Pubmed]
  11. Radioallergosorbent and indirect fluorescent antibody tests in immunodiagnosis of schistosomiasis. Weiss, N., Stürchler, D., Dietrich, F.M. Lancet (1978) [Pubmed]
  12. Subcellular localization of glyoxylate cycle enzymes in Ascaris suum larvae. Rubin, H., Trelease, R.N. J. Cell Biol. (1976) [Pubmed]
  13. Ascaris and growth rates: a randomized trial of treatment. Willett, W.C., Kilama, W.L., Kihamia, C.M. American journal of public health. (1979) [Pubmed]
  14. Effects of leukotriene D4 on mucociliary and respiratory function in allergic and nonallergic sheep. Russi, E.W., Abraham, W.M., Chapman, G.A., Stevenson, J.S., Codias, E., Wanner, A. J. Appl. Physiol. (1985) [Pubmed]
  15. Epidemiology and mass-treatment of ascariasis in six rural communities in central Iran. Arfaa, F., Ghadirian, E. Am. J. Trop. Med. Hyg. (1977) [Pubmed]
  16. Eosinophilia in athymic nude (rnu/rnu) rats--thymus-independent eosinophilia? Pritchard, D.I., Eady, R.P. Immunology (1981) [Pubmed]
  17. Participation of nitric oxide in the sympathetic response to anaphylactic hypotension in anesthetized dogs. Shibamoto, T., Wang, H.G., Tanaka, S., Miyahara, T., Koyama, S. Neurosci. Lett. (1996) [Pubmed]
  18. Correlation between hysteresis and allosteric properties for phosphofructokinase from Ascaris suum. Cook, P.F., Rao, G.S., Hofer, H.W., Harris, B.G. J. Biol. Chem. (1987) [Pubmed]
  19. Stage-specific isoforms of complex II (succinate-ubiquinone oxidoreductase) in mitochondria from the parasitic nematode, Ascaris suum. Saruta, F., Kuramochi, T., Nakamura, K., Takamiya, S., Yu, Y., Aoki, T., Sekimizu, K., Kojima, S., Kita, K. J. Biol. Chem. (1995) [Pubmed]
  20. Inhibition of antigen-induced bronchoconstriction by methylprednisolone succinate. Delehunt, J.C., Yerger, L., Ahmed, T., Abraham, W.M. J. Allergy Clin. Immunol. (1984) [Pubmed]
  21. Solution structure of the motile major sperm protein (MSP) of Ascaris suum - evidence for two manganese binding sites and the possible role of divalent cations in filament formation. Haaf, A., LeClaire, L., Roberts, G., Kent, H.M., Roberts, T.M., Stewart, M., Neuhaus, D. J. Mol. Biol. (1998) [Pubmed]
  22. Crystallization of the NAD-dependent malic enzyme from the parasitic nematode Ascaris suum. Clancy, L.L., Rao, G.S., Finzel, B.C., Muchmore, S.W., Holland, D.R., Watenpaugh, K.D., Krishnamurthy, H.M., Sweet, R.M., Cook, P.F., Harris, B.G. J. Mol. Biol. (1992) [Pubmed]
  23. glh-1, a germ-line putative RNA helicase from Caenorhabditis, has four zinc fingers. Roussell, D.L., Bennett, K.L. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  24. NAD+-malic enzyme. Regulatory properties of the enzyme from Ascaris suum. Landsperger, W.J., Harris, B.G. J. Biol. Chem. (1976) [Pubmed]
  25. Augmentation of respiratory mast cell secretion of histamine caused by vagus nerve stimulation during antigen challenge. Leff, A.R., Stimler, N.P., Munoz, N.M., Shioya, T., Tallet, J., Dame, C. J. Immunol. (1986) [Pubmed]
  26. Intestinal basement membrane of Ascaris suum. Molecular organization and properties of the collagen molecules. Noelken, M.E., Wisdom, B.J., Dean, D.C., Hung, C.H., Hudson, B.G. J. Biol. Chem. (1986) [Pubmed]
  27. IgE regulation by nematodes: the body fluid of Ascaris contains a B-cell mitogen. Lee, T.D., Xie, C.Y. J. Allergy Clin. Immunol. (1995) [Pubmed]
  28. Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3. Ng, K.K., Petersen, J.F., Cherney, M.M., Garen, C., Zalatoris, J.J., Rao-Naik, C., Dunn, B.M., Martzen, M.R., Peanasky, R.J., James, M.N. Nat. Struct. Biol. (2000) [Pubmed]
  29. Localization of choline acetyltransferase within identified motoneurons of the nematode Ascaris. Johnson, C.D., Stretton, A.O. J. Neurosci. (1985) [Pubmed]
  30. MHC restriction of the antibody repertoire to secretory antigens, and a major allergen, of the nematode parasite Ascaris. Tomlinson, L.A., Christie, J.F., Fraser, E.M., McLaughlin, D., McIntosh, A.E., Kennedy, M.W. J. Immunol. (1989) [Pubmed]
  31. Identification of a novel dihydrolipoyl dehydrogenase-binding protein in the pyruvate dehydrogenase complex of the anaerobic parasitic nematode, Ascaris suum. Klingbeil, M.M., Walker, D.J., Arnette, R., Sidawy, E., Hayton, K., Komuniecki, P.R., Komuniecki, R. J. Biol. Chem. (1996) [Pubmed]
  32. A phosphorylcholine idiotype related to TEPC 15 in mice infected with Ascaris suum. Brown, A.R., Crandall, C.A. J. Immunol. (1976) [Pubmed]
  33. Human infection with Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgR. Cooper, P.J., Chico, M., Sandoval, C., Espinel, I., Guevara, A., Levine, M.M., Griffin, G.E., Nutman, T.B. Infect. Immun. (2001) [Pubmed]
  34. Mutation scanning-coupled analysis of haplotypic variability in mitochondrial DNA regions reveals low gene flow between human and porcine Ascaris in endemic regions of China. Peng, W., Yuan, K., Hu, M., Zhou, X., Gasser, R.B. Electrophoresis (2005) [Pubmed]
  35. Novel gene structure and evolutionary context of Caenorhabditis elegans globin. Kloek, A.P., Sherman, D.R., Goldberg, D.E. Gene (1993) [Pubmed]
  36. Cloning and characterisation of a peroxiredoxin from the swine roundworm Ascaris suum. Tsuji, N., Kasuga-Aoki, H., Isobe, T., Yoshihara, S. Int. J. Parasitol. (2000) [Pubmed]
  37. Vaccination with recombinant Ascaris suum 24-kilodalton antigen induces a Th1/Th2-mixed type immune response and confers high levels of protection against challenged Ascaris suum lung-stage infection in BALB/c mice. Islam, M.K., Miyoshi, T., Tsuji, N. Int. J. Parasitol. (2005) [Pubmed]
  38. Heterogeneity of allergic airway responses in sheep: differences in signal transduction? Ahmed, T., D'Brot, J., Abraham, W.M., Lucio, J., Mendelssohn, R., Robinson, M.J., Shakir, S., Sanpedro, B. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  39. Heterogeneity of cholecystokinin/gastrin-like immunoreactivity in the nervous system of the nematode Ascaris suum. Sithigorngul, P., Cowden, C., Stretton, A.O. J. Comp. Neurol. (1996) [Pubmed]
  40. Levamisole-activated single-channel currents from muscle of the nematode parasite Ascaris suum. Robertson, S.J., Martin, R.J. Br. J. Pharmacol. (1993) [Pubmed]
  41. Distribution of 3H-GABA uptake sites in the nematode Ascaris. Guastella, J., Stretton, A.O. J. Comp. Neurol. (1991) [Pubmed]
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