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Chemical Compound Review:

LS-63131 (2S)-3-[2-(3,4- dimethoxyphenyl)-1,3...

Synonyms: AC1L53CN, Ro 44-5912, 168037-93-2

Eliason, J.F. et al., Abderrabi, M. et al.

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Disease relevance of Ro 44-5912

In non-tumour bearing mice, Ro 44-5912 enhanced the toxicity of vinblastine in a manner that was dependent on the dose of both drugs [1].

High impact information on Ro 44-5912

Ro 44-5912 also significantly enhanced vinblastine activity with P-glycoprotein-expressing KB-8-5 tumours [1].
These results show that Ro 44-5912 is an active modulator of drug resistance in vivo [1].
Ro 11-2933 was found to be the most potent in modulating MDR but was not significantly more active than Ro 44-5912 [2].

References

The dithiane Ro 44-5912 enhances vinblastine sensitivity of drug resistant and parental KB lines in vivo. Eliason, J.F., Sawada, R., Tsukaguchi, T., Kobayashi, K., Ichihara, S., Konishi, C., Horii, I., Kuruma, I., Ramuz, H. Eur. J. Cancer (1995) [Pubmed]
Comparative in vitro evaluation of dithiane analogs of tiapamil, Ro 11-2933, Ro 44-5911 and Ro 44-5912 as multidrug resistance modulators. Abderrabi, M., Marchal, S., Merlin, J.L. Anticancer Drugs (1996) [Pubmed]

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