Disease relevance of Vitalethine

• Because dosages of vitalethine as low as femtograms/kg substantially diminish tumor size and incidence and increase survival to 80% in mice inoculated with a uniformly fatal melanoma (Cloudman S-91), activities of these compounds have in vivo significance [1].

High impact information on Vitalethine

• Vitalethine modulates erythropoiesis and neoplasia [1].
• A preliminary probe of the benzyl derivative of vitalethine in a myeloma model (NS-1) suggests efficacy (100% survival) as well [1].

Analytical, diagnostic and therapeutic context of Vitalethine

• Similarly, as little as attograms/ml concentrations of the disulfide vitalethine stimulate immunological responses of murine splenocytes toward sheep RBC in a hemolytic plaque assay [1].

References