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Chemical Compound Review:

PubChem18662 2-methyl-1-nitro-guanidine

Synonyms: ACMC-1AHLM, CCRIS 6728, AG-F-50953, ANW-41161, NSC-11887, ...

Chen, J. et al., Kinkead, E.R. et al., Mikuni, T. et al.

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Disease relevance of NSC 11887

N-methyl-N'-nitroguanidine: irritation, sensitization, and acute oral toxicity, genotoxicity, and methods for analysis in biological samples [1].

High impact information on NSC 11887

An analytical HPLC method was developed to assay denitrosation of MNNG to N-methyl-N'-nitroguanidine (MNG) by cytosolic, microsomal, mitochondrial, and nuclear cell fractions [2].

Analytical, diagnostic and therapeutic context of NSC 11887

The formation of N-methyl-N'-nitroguanidine in the mixture at pH 7.8 was confirmed by thin-layer chromatography and melting point [3].

References

N-methyl-N'-nitroguanidine: irritation, sensitization, and acute oral toxicity, genotoxicity, and methods for analysis in biological samples. Kinkead, E.R., Wolfe, R.E., Salins, S.A., Godin, C.S., Lu, P.P., Ketcha, M.M., Thilagar, A., Brashear, W.T. Toxicology and industrial health. (1993) [Pubmed]
Biochemical mechanisms on species differences in gastric carcinogenesis. Chen, J., Barnes, W.S., Maiello, J., Weisburger, J.H. J. Cancer Res. Clin. Oncol. (1984) [Pubmed]
Hydroxyl free radical production by the reaction of N-methyl-N'-nitro-N-nitrosoguanidine with hydrogen peroxide without exposure to light. Mikuni, T., Tatsuta, M., Kamachi, M. Biochem. Cell Biol. (1992) [Pubmed]

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