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Chemical Compound Review:

AG-G-90646 2-(diaminomethylideneamino) pentanedioic acid

Synonyms: AG-K-70336, ACMC-209or3, G7788_SIGMA, AC1L1CXI, CTK5D9704, ...

Yokoi, I. et al., Cordelier, P. et al., Natelson, S., Mori, A. et al., Mori, A. et al.

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Disease relevance of alpha-guanidinoglutaric acid

alpha-Guanidinoglutaric acid (alpha-GGA) has been reported to occur in the cerebral cortex after epileptic seizures [1].

High impact information on alpha-guanidinoglutaric acid

The production of NO was involved in the proliferative response elicited by CCK regarding the inhibitory effect of NOS inhibitors L-NAME and alpha-guanidinoglutaric acid [2].
The effects of alpha-guanidinoglutaric acid (GGA), the levels of which were increased in the cobalt-induced epileptic focus tissue in the cerebral cortex of cats, on brain nitric oxide synthase (NOS) activity were observed [3].
alpha-Guanidinoglutaric acid and epilepsy [4].

Anatomical context of alpha-guanidinoglutaric acid

alpha-Guanidinoglutaric acid in cobalt-induced epileptogenic cerebral cortex of cats [5].

References

The lactam of alpha-guanidinoglutaric acid (1-amidino-2-pyrrolidone-5-carboxylic acid). Natelson, S. Anal. Biochem. (1986) [Pubmed]
The activation of neuronal NO synthase is mediated by G-protein betagamma subunit and the tyrosine phosphatase SHP-2. Cordelier, P., Estève, J.P., Rivard, N., Marletta, M., Vaysse, N., Susini, C., Buscail, L. FASEB J. (1999) [Pubmed]
alpha-Guanidinoglutaric acid, an endogenous convulsant, as a novel nitric oxide synthase inhibitor. Yokoi, I., Kabuto, H., Habu, H., Mori, A. J. Neurochem. (1994) [Pubmed]
alpha-Guanidinoglutaric acid and epilepsy. Mori, A., Watanabe, Y., Shindo, S., Akagi, M., Hiramatsu, M. Adv. Exp. Med. Biol. (1982) [Pubmed]
alpha-Guanidinoglutaric acid in cobalt-induced epileptogenic cerebral cortex of cats. Mori, A., Akagi, M., Katayama, Y., Watanabe, Y. J. Neurochem. (1980) [Pubmed]

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