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MeSH Review

Cerebral Cortex

 
 
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Disease relevance of Cerebral Cortex

 

Psychiatry related information on Cerebral Cortex

 

High impact information on Cerebral Cortex

  • The hyh (hydrocephalus with hop gait) mouse shows a markedly small cerebral cortex at birth and dies postnatally from progressive enlargement of the ventricular system [11].
  • Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex [12].
  • Lissencephaly ("smooth brain," from "lissos," meaning smooth, and "encephalos," meaning brain) is a severe developmental disorder in which neuronal migration is impaired, leading to a thickened cerebral cortex whose normally folded contour is simplified and smooth [13].
  • Layering of neurons in the cerebral cortex and cerebellum requires Reelin, an extracellular matrix protein, and mammalian Disabled (mDab1), a cytosolic protein that activates tyrosine kinases [14].
  • In the caudate nucleus of choreic brain, both enzyme activities were markedly lower, with significant decreases in muscarinic cholinergic and serotonin receptor binding, whereas enzyme activities and receptor binding were unchanged in the cerebral cortex [15].
 

Chemical compound and disease context of Cerebral Cortex

 

Biological context of Cerebral Cortex

 

Anatomical context of Cerebral Cortex

 

Associations of Cerebral Cortex with chemical compounds

 

Gene context of Cerebral Cortex

  • Here we demonstrate that the doubly transgenic progeny from a cross between line Tg2576 and a mutant PS1M146L transgenic line develop large numbers of fibrillar A beta deposits in cerebral cortex and hippocampus far earlier than their singly transgenic Tg2576 littermates [36].
  • Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression [37].
  • Here, we show that Hsf2-/- cerebral cortex displays mispositioning of neurons of superficial layers [37].
  • Mammalian homeogenes of the Emx family, Emx1 and Emx2, are expressed in the developing cerebral cortex and are involved in the patterning of the rostral brain [38].
  • Such endothelial dysfunction was not found in transgenic mice expressing both APP and superoxide dismutase-1 (SOD1) or in APP transgenics in which SOD was topically applied to the cerebral cortex [39].
 

Analytical, diagnostic and therapeutic context of Cerebral Cortex

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