Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC-034 4-aminobutan-1-ol

Synonyms: AG-C-84194, AG-D-67701, ACMC-209brn, ACN-S003377, ANW-19521, ...

Ekstrom, J.L. et al., Liu, X.C. et al.

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High impact information on AI3-28710

Studies of the effects of putrescine or 4-aminobutanol on the processing of mutant AdoMetDC proenzymes are consistent with a model in which a single activator molecule interacts with buried Asp174, Glu178, and Glu256, leading to an alteration in the position of Glu11, resulting in stimulation of self-processing [1].
The carboxylic acid and amine precursors are based on 3-hydroxybutyrate and 4-amino-1-butanol, respectively, and have been acylated selectively using a variety of acyl donors catalyzed by porcine pancreatic lipase [2].

References

Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant. Ekstrom, J.L., Tolbert, W.D., Xiong, H., Pegg, A.E., Ealick, S.E. Biochemistry (2001) [Pubmed]
Chemoenzymatic construction of a four-component Ugi combinatorial library. Liu, X.C., Clark, D.S., Dordick, J.S. Biotechnol. Bioeng. (2000) [Pubmed]

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