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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Tissue Donors

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Disease relevance of Tissue Donors


Psychiatry related information on Tissue Donors

  • A series of 30 patients who were not eligible for standard conditioning therapy received transplants from HLA-matched related (n = 14) or unrelated (n = 16) donors after administration of treosulfan 10 g/m2 intravenously daily for 3 days and fludarabine 30 mg/m2 intravenously daily for 5 days [6].
  • We selected 101 sera; 16 were obtained from normal donors with no known risk factors, and 85 were from patients with full-fledged AIDS (28 cases), AIDS-related complex (ARC, 22 cases), and healthy people at risk (homosexuals, intravenous [IV] drug users, relatives of AIDS patients; 35 cases) [7].
  • C57BL FX and midvaginal transplants from 1-, 3-, and 5-day-old donors but not from 7- or 10-day-old donors developed adenosis, indicating a critical period before day 6 [8].
  • This study describes the expression of MHC class II antigens in retinal flat mounts from normal donors and patients with Alzheimer's disease (AD) [9].
  • For 20 selected donors representing the spectrum of CD4 T-cell permissiveness, we could attribute up to 42% of the total variance in virus production to entry factors and 48% to postentry steps [10].

High impact information on Tissue Donors

  • While in most instances, they function as inhibiting receptors, an activating form of the HLA-C-specific receptors has been identified in some donors [11].
  • Techniques using synthetic oligonucleotide probes to mutant DNA sequence demonstrated that other class-I genes were available as donors for interaction with the Kb gene to produce the mutations [12].
  • Immune-deficient Rag2(-/-) mice were used as nuclear donors for transfer into enucleated oocytes, and the resulting blastocysts were cultured to isolate an isogenic embryonic stem cell line [13].
  • BACKGROUND: Successful engraftment of hematopoietic stem cells from unrelated donors is influenced by disparities between the donor and recipient for HLA-A, B, and C alleles [14].
  • The results were compared with those in 10 infants who received heart transplants from ABO-compatible donors [15].

Chemical compound and disease context of Tissue Donors


Biological context of Tissue Donors


Anatomical context of Tissue Donors


Associations of Tissue Donors with chemical compounds

  • We conclude that in healthy donors hemipancreatectomy results in a deterioration of insulin secretion and glucose tolerance, as measured one year later [30].
  • To determine whether steroids exert a direct inhibitory effect on neutrophil function, thus contraindicating their use to increase granulocyte yields for white-cell transfusions to infected neutropenic patients, we gave normal donors a single intravenous dose of dexamethasone (4 mg per square meter of body-surface area) [26].
  • Radioallergosorbent testing revealed that serum from 4 of the 6 donors who had reactions, but from only 1 of 145 controls, contained IgE antibodies to ethylene oxide-albumin (P less than 0.001) [4].
  • In 17 (11 percent) of the Western blot-positive donors, the disease progressed to Class IV (symptomatic disease), according to the Centers for Disease Control system [31].
  • Nitric oxide, generated from NO. donors or synthesized endogenously after NMDA (N-methyl-D-aspartate) receptor activation, can lead to neurotoxicity [32].

Gene context of Tissue Donors

  • The donors have a chromatin structure inaccessible for both transcription and HO cleavage [33].
  • On the other hand, NO donors conjugated with COX inhibitors have recently found new interest in the understanding of NO/COX reciprocal interaction and potential clinical use [34].
  • The capacity of T cells from anti-IgD-injected donors to produce IL-4 is enhanced by addition of IL-2 and is largely, but not completely, inhibited by neutralization of in situ produced IL-2 [35].
  • To test the hypothesis that nitric oxide (NO) limits endothelial activation, we treated cytokine-stimulated human saphenous vein endothelial cells with several NO donors and assessed their effects on the inducible expression of vascular cell adhesion molecule-1 (VCAM-1) [36].
  • Hybridization signal for BDNF, but not NGF or NT-3, was decreased in samples of hippocampus from donors with AD [37].

Analytical, diagnostic and therapeutic context of Tissue Donors

  • BACKGROUND: Transplantation of hearts from ABO-incompatible donors is contraindicated because of the risk of hyperacute rejection mediated by preformed antibodies in the recipient to blood-group antigens of the donor [15].
  • Allergic reactions in healthy plateletpheresis donors caused by sensitization to ethylene oxide gas [4].
  • To determine the metabolic consequences of this procedure for the donors, we carried out oral glucose-tolerance testing and 24-hour monitoring of serum glucose levels and urinary C-peptide excretion as a measure of insulin secretion in 28 donors, both before and one year after hemipancreatectomy [30].
  • Cytotoxic T lymphocytes (CTLs) specific for mHags of the recipients can be isolated from the blood of recipients with severe GvHD (ref. 3). A retrospective study demonstrated an association between mismatch for mHags HA-1, -2, -4 and -5 and the occurrence of GvHD in adult recipients of bone marrow from HLA genotypically identical donors [38].
  • High levels of antibodies to most parasite proteins were detected by Western blots in the receivers' sera (taken before transfer) as in the donors' Ig, thus indicating that the difference was qualitative rather than quantitative between donors and receivers [39].


  1. Evaluation of screened blood donations for human immunodeficiency virus type 1 infection by culture and DNA amplification of pooled cells. Busch, M.P., Eble, B.E., Khayam-Bashi, H., Heilbron, D., Murphy, E.L., Kwok, S., Sninsky, J., Perkins, H.A., Vyas, G.N. N. Engl. J. Med. (1991) [Pubmed]
  2. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. Alter, H.J., Purcell, R.H., Shih, J.W., Melpolder, J.C., Houghton, M., Choo, Q.L., Kuo, G. N. Engl. J. Med. (1989) [Pubmed]
  3. Enzyme replacement therapy for adenosine deaminase deficiency and severe combined immunodeficiency. Polmar, S.H., Stern, R.C., Schwartz, A.L., Wetzler, E.M., Chase, P.A., Hirschhorn, R. N. Engl. J. Med. (1976) [Pubmed]
  4. Allergic reactions in healthy plateletpheresis donors caused by sensitization to ethylene oxide gas. Leitman, S.F., Boltansky, H., Alter, H.J., Pearson, F.C., Kaliner, M.A. N. Engl. J. Med. (1986) [Pubmed]
  5. Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen). Brown, K.E., Hibbs, J.R., Gallinella, G., Anderson, S.M., Lehman, E.D., McCarthy, P., Young, N.S. N. Engl. J. Med. (1994) [Pubmed]
  6. Treosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation. Casper, J., Knauf, W., Kiefer, T., Wolff, D., Steiner, B., Hammer, U., Wegener, R., Kleine, H.D., Wilhelm, S., Knopp, A., Hartung, G., Dölken, G., Freund, M. Blood (2004) [Pubmed]
  7. Spectrum of natural antibodies against five HTLV-III antigens in infected individuals: correlation of antibody prevalence with clinical status. Franchini, G., Robert-Guroff, M., Aldovini, A., Kan, N.C., Wong-Staal, F. Blood (1987) [Pubmed]
  8. Induction of abnormal epithelial changes by estrogen in neonatal mouse vaginal transplants. Iguchi, T., Ostrander, P.L., Mills, K.T., Bern, H.A. Cancer Res. (1985) [Pubmed]
  9. Modulation of MHC class II expression in the absence of lymphocytic infiltrates in Alzheimer's retinae. Liew, S.C., Penfold, P.L., Provis, J.M., Madigan, M.C., Billson, F.A. J. Neuropathol. Exp. Neurol. (1994) [Pubmed]
  10. Entry and transcription as key determinants of differences in CD4 T-cell permissiveness to human immunodeficiency virus type 1 infection. Ciuffi, A., Bleiber, G., Muñoz, M., Martinez, R., Loeuillet, C., Rehr, M., Fischer, M., Günthard, H.F., Oxenius, A., Meylan, P., Bonhoeffer, S., Trono, D., Telenti, A. J. Virol. (2004) [Pubmed]
  11. Receptors for HLA class-I molecules in human natural killer cells. Moretta, A., Bottino, C., Vitale, M., Pende, D., Biassoni, R., Mingari, M.C., Moretta, L. Annu. Rev. Immunol. (1996) [Pubmed]
  12. Murine major histocompatibility complex class-I mutants: molecular analysis and structure-function implications. Nathenson, S.G., Geliebter, J., Pfaffenbach, G.M., Zeff, R.A. Annu. Rev. Immunol. (1986) [Pubmed]
  13. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Rideout, W.M., Hochedlinger, K., Kyba, M., Daley, G.Q., Jaenisch, R. Cell (2002) [Pubmed]
  14. Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. Petersdorf, E.W., Hansen, J.A., Martin, P.J., Woolfrey, A., Malkki, M., Gooley, T., Storer, B., Mickelson, E., Smith, A., Anasetti, C. N. Engl. J. Med. (2001) [Pubmed]
  15. ABO-incompatible heart transplantation in infants. West, L.J., Pollock-Barziv, S.M., Dipchand, A.I., Lee, K.J., Cardella, C.J., Benson, L.N., Rebeyka, I.M., Coles, J.G. N. Engl. J. Med. (2001) [Pubmed]
  16. Effects of dimethyl sulfoxide on renal function in man. Muther, R.S., Bennett, W.M. JAMA (1980) [Pubmed]
  17. Prospective study of serum micronutrients and ovarian cancer. Helzlsouer, K.J., Alberg, A.J., Norkus, E.P., Morris, J.S., Hoffman, S.C., Comstock, G.W. J. Natl. Cancer Inst. (1996) [Pubmed]
  18. Immunochemical characterization of fetal antigen isolated from spent medium of a human melanoma cell line. Gupta, R.K., Morton, D.L. J. Natl. Cancer Inst. (1983) [Pubmed]
  19. NADPH oxidase deficiency in X-linked chronic granulomatous disease. Hohn, D.C., Lehrer, R.I. J. Clin. Invest. (1975) [Pubmed]
  20. Distribution of latex-ingesting cells, T cells, and B cells in the peripheral blood of patients with malignant melanoma. Koziner, B., Cosimi, A.B., Bloch, K.J. J. Natl. Cancer Inst. (1975) [Pubmed]
  21. Effect of HLA-A and HLA-B matching on survival of grafts and recipients after renal transplantation. Persijn, G.G., Cohen, B., Lansbergen, Q., D'Amaro, J., Selwood, N., Wing, A., van Rood, J.J. N. Engl. J. Med. (1982) [Pubmed]
  22. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. Aversa, F., Tabilio, A., Velardi, A., Cunningham, I., Terenzi, A., Falzetti, F., Ruggeri, L., Barbabietola, G., Aristei, C., Latini, P., Reisner, Y., Martelli, M.F. N. Engl. J. Med. (1998) [Pubmed]
  23. Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Tsurumi, Y., Murohara, T., Krasinski, K., Chen, D., Witzenbichler, B., Kearney, M., Couffinhal, T., Isner, J.M. Nat. Med. (1997) [Pubmed]
  24. Chemical alkylation of lead (II) salts to tetraalkyllead (IV) in aqueous solution. Ahmad, I., Chau, Y.K., Wong, P.T., Carty, A.J., Taylor, L. Nature (1980) [Pubmed]
  25. Agrobacterium conjugation and gene regulation by N-acyl-L-homoserine lactones. Zhang, L., Murphy, P.J., Kerr, A., Tate, M.E. Nature (1993) [Pubmed]
  26. Functional capabilities of steroid-recruited neutrophils harvested for clinical transfusion. Glasser, L., Huestis, D.W., Jones, J.F. N. Engl. J. Med. (1977) [Pubmed]
  27. Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Schaible, U.E., Winau, F., Sieling, P.A., Fischer, K., Collins, H.L., Hagens, K., Modlin, R.L., Brinkmann, V., Kaufmann, S.H. Nat. Med. (2003) [Pubmed]
  28. Increased sensitivity of lymphocytes from people over 65 to cell cycle arrest and chromosomal damage. Staiano-Coico, L., Darzynkiewicz, Z., Hefton, J.M., Dutkowski, R., Darlington, G.J., Weksler, M.E. Science (1983) [Pubmed]
  29. Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Schnieke, A.E., Kind, A.J., Ritchie, W.A., Mycock, K., Scott, A.R., Ritchie, M., Wilmut, I., Colman, A., Campbell, K.H. Science (1997) [Pubmed]
  30. Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans. Kendall, D.M., Sutherland, D.E., Najarian, J.S., Goetz, F.C., Robertson, R.P. N. Engl. J. Med. (1990) [Pubmed]
  31. Clinical implications of positive tests for antibodies to human immunodeficiency virus type 1 in asymptomatic blood donors. Leitman, S.F., Klein, H.G., Melpolder, J.J., Read, E.J., Esteban, J.I., Leonard, E.M., Harvath, L., Shih, J.W., Nealon, R., Foy, J. N. Engl. J. Med. (1989) [Pubmed]
  32. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Lipton, S.A., Choi, Y.B., Pan, Z.H., Lei, S.Z., Chen, H.S., Sucher, N.J., Loscalzo, J., Singel, D.J., Stamler, J.S. Nature (1993) [Pubmed]
  33. DNA structure-dependent requirements for yeast RAD genes in gene conversion. Sugawara, N., Ivanov, E.L., Fishman-Lobell, J., Ray, B.L., Wu, X., Haber, J.E. Nature (1995) [Pubmed]
  34. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., Salvemini, D. Pharmacol. Rev. (2005) [Pubmed]
  35. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. Le Gros, G., Ben-Sasson, S.Z., Seder, R., Finkelman, F.D., Paul, W.E. J. Exp. Med. (1990) [Pubmed]
  36. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. De Caterina, R., Libby, P., Peng, H.B., Thannickal, V.J., Rajavashisth, T.B., Gimbrone, M.A., Shin, W.S., Liao, J.K. J. Clin. Invest. (1995) [Pubmed]
  37. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Phillips, H.S., Hains, J.M., Armanini, M., Laramee, G.R., Johnson, S.A., Winslow, J.W. Neuron (1991) [Pubmed]
  38. Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease. Mutis, T., Gillespie, G., Schrama, E., Falkenburg, J.H., Moss, P., Goulmy, E. Nat. Med. (1999) [Pubmed]
  39. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. Bouharoun-Tayoun, H., Attanath, P., Sabchareon, A., Chongsuphajaisiddhi, T., Druilhe, P. J. Exp. Med. (1990) [Pubmed]
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